Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-22T17:30:55.872Z Has data issue: false hasContentIssue false
  • English
  • Français

Long-term memory loss and the effects of tianeptine in young and aged mice

Published online by Cambridge University Press:  16 April 2020

C Lebrun  and
R Jaffard
C Lebrun
Affiliation:
Laboratoire de Neurosciences Comportementales et Cognitives, URA CNRS 339, Université de Bordeaux I, Avenue des Facultés, 33405Talence Cedex, France
R Jaffard
Affiliation:
Laboratoire de Neurosciences Comportementales et Cognitives, URA CNRS 339, Université de Bordeaux I, Avenue des Facultés, 33405Talence Cedex, France
Get access

Summary

Previous experiments have shown that tianeptine, a new psychotropic agent with antidepressant properties, improves performance in several learning and memory tasks in mice. In more recent investigations, tianeptine was found to completely alleviate working memory deficits produced by long-term alcohol intoxication and to prevent abnormal memory loss in aged animals (Jaffard et al, 1991b, 1991c). The aim of this paper was to examine how this last finding may be integrated in our understanding of brain mechanisms involved in memory loss. For this purpose, we present a brief review of experimental data and theories which, at different levels of analysis, seems to be relevant to this issue. Together with the subsequent examination of the conditions in which tianeptine was found to improve long-term retention, we suggest that: i) long-term memory loss would be largely determined by the initial encoding of information, so that ii) tianeptine would help aged animals to use spatial mapping or configural associations more efficiently at the time of initial acquisition. This, in turn, suggests that one of the main brain target sites for tianeptine in enhancing memory is the hippocampal formation.

Keywords

tianeptinelong-term memory lossagingmiceencoding strategiesspatial mappinghippocampuspermastore
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S2: Neuroendocrinological aspects of depression 28 June 1992, Nice, France , 1993 , pp. 81s - 88s
Copyright
Copyright © Elsevier, Paris 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bahrick, HP (1979) Maintenance of knowledge. Questions about memory we forgot to ask. J Exp Psychol 108, 296–308CrossRefGoogle Scholar
Bahrick, HP (1984) Semantic memory content in permastore: fifty years of memory for Spanish learned in school J Exp Psychol 113, 1–29CrossRefGoogle ScholarPubMed
Barnes, CA (1988) Spatial learning and memory processes: the search for their neurobiological mechanisms in the rat TINS 11, 163–169Google ScholarPubMed
Béracochéa, DJTako, ANJaffard, R (1989) Accelerated rates of forgetting of spatial information during aging and long-term ethanol consumption in mice: evidence for two distinct forms of amnesia. Psychobiology 17, 358–362Google Scholar
Béracochéa, DJMicheau, JJaffard, R (1992) Memory deficits following chronic alcohol consumption in mice: relationships with hippocampal and cortical cholinergic activities. Pharmacol Biochem Behav 42(4) 749–753CrossRefGoogle ScholarPubMed
Black, LB (1986) Molecular memory mechanisms.In: Synapses, Circuits and the Beginnings of Memory (Lynch, G ed). A Bradford Book, 99–109Google Scholar
Bures, JBuresova, O (1990) Reversible lesions allow reinterpretation of system level studies of brain mechanisms of behavior. Concepts Neurosci 1, 69–89Google Scholar
Cho, YH (1992) Implication de l'hippocampe et des régions parahippocampiques dans les processus d'apprentissage et de mémorisation chez la souris: amnésies antérograde et rétrograde. Thèse de Doctorat, Université de Bordeaux I, 0–181Google Scholar
Cho, YHBéracochéa, DJaffard, R (1993) Extended temporal gradient for retrograde and anterograde amnesia produced by ibotenate entorhinal cortex lesions in mice. J Neurosci 13, 1759–1766CrossRefGoogle ScholarPubMed
Damasio, AR (1990) Time-locked multi-regional retroactivation: systems-level proposal for the neural substrates of recall and recognition.In: Neurobiology of Cognition. MIT Press, pp 25–62Google Scholar
Deutsch, JA (1971) The cholinergic synapse and the site of memory. Science 174, 788–794CrossRefGoogle Scholar
Dunnet, SB (1990) Comparison of short-term memory deficits in animal models of ageing using an operant delayed response task in rats.In: The Biology of Memory (Squire, LRLindenlaub, E eds). FK Schattauer, Verlag, Stuttgart, New York, pp 581–603Google Scholar
Jaffard, R (1991) Mémoire animale, mémoire de l'homme.In: Mémoire et Vieillissement. Maloine 132–148Google Scholar
Jaffard, RBéracochéa, DCho, Y (1991a) The hippocampal- mammillary system: anterograde and retrograde amnesia. Hippocampus 1, 275–278CrossRefGoogle Scholar
Jaffard, RMarighetto, AMicheau, J (1992) Septal noradrenergic and glutamatergic influences on hippocampal cholinergic activity in relation to spatial learning and memory in mice.In: Neurotransmitter Interactions and Cognitive Functions (Levin, EDecker, MWButcher, GG eds). Birkhaüser, 103–117CrossRefGoogle Scholar
Jaffard, RMocaer, EPoignant, JCMicheau, JMarighetto, AMeunier, MBéracochéa, D (1991b) Effects of tianeptine on spontaneous alternation, simple and concurrent spatial discrimination learning and on alcohol-induced alternation deficits in mice. Behav Pharmacol 2, 37–46CrossRefGoogle Scholar
Jaffard, RMocaer, ELebrun, CBéracochéa, D (1991c) Effets de la tianeptine sur l'apprentissage et la mémoire chez la souris. Amélioration de certains déficits induits par l'alcoolisation chronique et le vieillissement cérébral. Presse Médicale 37, 1812–1816Google Scholar
Kausler, DH (1990) Experimental Psychology, Cognition, and Human Aging. Springer Verlag, 856 ppGoogle Scholar
Kinsbourne, M (1987) Brain mechanisms and memory. Hum Neurobiol 6, 681–692Google ScholarPubMed
Lebrun, CDurkin, TPMarighetto, AJaffard, R (1990) A comparison of the working memory performances of young and aged mice combined with parallel measures of testing and drug-induced activations of septohippocampal and nbm-cortical choli- nergic neurones. Neurobiol Aging 11, 515–521CrossRefGoogle Scholar
Nadel, L (1991) The hippocampus and space revisited. Hippocampus 1, 221–229CrossRefGoogle ScholarPubMed
McNaughton, BLMorris, RGM (1987) Hippocampal synaptic enhancement and information storage within a distributed memory system. TINS 10, 408–415Google Scholar
Neisser, U (1984) Interpreting Harry Bahrick's discovery: what confers immunity against forgetting? J Exp Psychol (Gen) 113, 32–35CrossRefGoogle Scholar
O‘Keefe, JNadel, L (1978) The hippocampus as a cognitive map. Clarendon, Oxford, pp 570Google Scholar
Polster, MRNadel, LSchacter, DL (1991) Cognitive neuroscience analyses of memory: a historical perspective. J Cog Neurosci 3, 95–116CrossRefGoogle ScholarPubMed
Sarter, M (1990) Retrieval of well-learned propositional rules: insensitive to changes in activity of individual neurotransmitter systems? Psychobiology 18(4), 451–459Google Scholar
Skarda, CAFreeman, WJ (1987) How brains make chaos in order to make sense of the world. Behav Brain Sci 10, 161–175CrossRefGoogle Scholar
Squire, LR (1992) Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans. Psychol Rev 99, 195–231CrossRefGoogle ScholarPubMed
Sutherland, RJRudy, JW (1989): Configural association theory: the role of the hippocampal formation in learning, memory, and amnesia. Psychobiology 17, 129–144Google Scholar
Teyler, TJDiScenna, P (1986) The hippocampal memory indexing theory. Behav Neurosci 100, 147–154CrossRefGoogle ScholarPubMed
Zola-Morgan, SMSquire, LR (1990) The primate hippocampal formation: evidence for a time-limited role in memory storage. Science 250, 288–290CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.