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Let-7, MiR-98 and MiR-181 as Biomarkers for Cancer and Schizophrenia

Published online by Cambridge University Press:  15 April 2020

E. Rizos ,
N. Siafakas ,
C.H. Papageorgiou ,
E. Katsantoni ,
E. Skourti ,
V. Salpeas ,
I. Rizos ,
J.N. Tsoporis ,
T.G. Parker  and
N. Xiros
...Show all authors
E. Rizos
Affiliation:
2nd psychiatric Department, ATTIKON UNIVERSITY HOSPITAL, ATHENS, Greece
N. Siafakas
Affiliation:
Microbiology Laboratory, ATTIKON UNIVERSITY HOSPITAL, ATHENS, Greece
C.H. Papageorgiou
Affiliation:
2nd psychiatric Department, ATTIKON UNIVERSITY HOSPITAL, ATHENS, Greece
E. Katsantoni
Affiliation:
Hematology-Oncology Division., Biomedical Research Foundation Academy of Athens., ATHENS, Greece
E. Skourti
Affiliation:
National Hellenic Research Foundation., Institute of Biology., ATHENS, Greece
V. Salpeas
Affiliation:
2nd Cardiology Department., University General Hospital “ATTIKON”, ATHENS, Greece
I. Rizos
Affiliation:
2nd Cardiology Department., University General Hospital “ATTIKON”, ATHENS, Greece
J.N. Tsoporis
Affiliation:
Keeman Research Centre St. Michael's Hospital., Li Ka Shing Knowledge Institute for Biomedical Science., Toronto, Canada
T.G. Parker
Affiliation:
Keeman Research Centre St. Michael's Hospital., Li Ka Shing Knowledge Institute for Biomedical Science., Toronto, Canada
N. Xiros
Affiliation:
Medical Oncology Unit 2nd Department of Internal Medicine Propaedeutic., University General Hospital “ATTIKON”, Toronto, Canada
A. Kastania
Affiliation:
Department of Informatics, Athens University of Economics and Business., Athens, Greece
V. Zoumpourlis
Affiliation:
National Hellenic Research Foundation., Institute of Biology., Athens, Greece

Abstract

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Backround

Recent studies support an important role of microRNAs in cancer and major psychiatric disorders, through their regulotory role on the expression of multiple genes. The low incidence of cancer in patients with schizophrenia as a comorbidity status, is an old hypothesis which needs further investigation mainly on microRNAs function, through their oncosupressive or oncogenic activity, in the development of psychiatric disorders.

Material and Methods

The expression pattern of a variety of different was investigated in a sample of patients suffering from schizophrenia (n=6), in a another sample wit a solid tumor (n=10) and in a sample of patients with both schizophrenia and tumor (n=8). MiRNAs analysis was performed in whole blood samples using the miRCURY LNA TM microRNA Aray technology.

Results

A number of 3 microRNAs showed a statistically significant differential expression between the 3 groups. Specifically, significant down-regulation of the let-7p-5p, miR-98-5p and miR-183-5p in the study groups of tumor alone and and tumorand schizophrenia.

Conclusions

The results of the present study that let-7, miR-98 and miR-183 might play an important oncosuppressive role through their regulatory impact in gene expression irrespective of the presence of schizophrenia. Further studies are warranted in order to investigate of these and other mico-RNAs in the molecular pathways of schizophrenia and of other major psychiatric disorders.

Type
Article: 0313
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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