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Late onset schizophrenia and delusional disorder: activity of platelet energy, glutamate, and glutathione metabolizing enzymes

Published online by Cambridge University Press:  01 September 2022

V. Pochueva ,
O. Savushkina ,
I. Boksha ,
E. Tereshkina ,
T. Prokhorova ,
V. Sheshenin ,
E. Vorobyeva  and
G. Burbaeva
V. Pochueva*
Affiliation:
FSBSI “Mental Health Research Centre”, Geriatric Psychiatry, Moscow, Russian Federation
O. Savushkina
Affiliation:
FSBSI “Mental Health Research Centre”, Laboratory Of Neurochemistry, Moscow, Russian Federation
I. Boksha
Affiliation:
FSBSI “Mental Health Research Centre”, Laboratory Of Neurochemistry, Moscow, Russian Federation
E. Tereshkina
Affiliation:
FSBSI “Mental Health Research Centre”, Laboratory Of Neurochemistry, Moscow, Russian Federation
T. Prokhorova
Affiliation:
FSBSI “Mental Health Research Centre”, Laboratory Of Neurochemistry, Moscow, Russian Federation
V. Sheshenin
Affiliation:
FSBSI “Mental Health Research Centre”, Geriatric Psychiatry, Moscow, Russian Federation
E. Vorobyeva
Affiliation:
FSBSI “Mental Health Research Centre”, Laboratory Of Neurochemistry, Moscow, Russian Federation
G. Burbaeva
Affiliation:
FSBSI “Mental Health Research Centre”, Laboratory Of Neurochemistry, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Alterations of glutamate, energy and glutathione metabolism contribute to the pathogenesis of psychotic disorders

Objectives

Revealing clinical-biological correlations in patients with late onset schizophrenia and delusional disorder by determining clinical parameters and activity of platelet enzymes of energy, glutamate, and glutathione metabolism.

Methods

27 women of 45-80 years old were studied, with late onset schizophrenia or delusional disorder. Activity of platelet cytochrome c-oxidase (COX), glutamate dehydrogenase (GDH), glutathione reductase (GR) and glutathione-S-transferase (GST), and scores by PANSS, HAMD, MMSE, and CGI-S were evaluated twice: before and after the 28-th day of treatment. Activity of COX, GDH, GR, and GST was measured once in 23 women of 44-81 years old comprising the control group.

Results

As compared with controls, only GDH activity was found significantly decreased (before and after treatment, p<0.001). Clusterisation of patients by enzymatic activities resulted in 3 clusters significantly different by COX, GDH and GST. Significant correlations were found between enzymatic activities and scores by psychometric scales: in the cluster 1 (n=9) baseline COX activity correlated with scores by PANSS positive subscale (R=0.9, p=0.001) and with scores by MMSE (R=-0.9, p=0.002); in the cluster 2 (n=12) GR activity after treatment negatively correlated with scores by PANSS (R=-0.9, p=0.001), PANSS negative subscale (R=-0.8, p=0.004), and CGI-S (R=-0.9, p=0.001).

Conclusions

The revealed correlations between enzymatic activities and clinical parameters give hope on detection of useful biochemical markers which, after enlargement of patients’ group with late onset psychotic disorders, would be validated for prediction of the pharmacotherapy efficiency and outcome of treatment.

Disclosure

No significant relationships.

Keywords

glutamate dehydrogenaseglutathione reductaseglutathione-S- transferaselate onset schizophrenia
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S778 - S779
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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