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Ischemic colitis induced by psychotropics drugs: a case report

Published online by Cambridge University Press:  01 September 2022

C. Alvarez Garcia*
Affiliation:
Hospital Universitario Príncipe de Asturias, Psychiatry, Alcalá de Henares, Spain
A. Sanz Giancola
Affiliation:
Hospital Universitario Príncipe de Asturias, Psychiatry, Alcalá de Henares, Spain
L. Nocete Navarro
Affiliation:
Hospital Universitario Príncipe de Asturias, Psychiatry, Alcalá de Henares, Spain
*
*Corresponding author.

Abstract

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Introduction

Ischemic colitis (IC) is a rare condition due to hypoperfusion in the large intestine. Usually the etiology is unidentified, but many drugs are known to induce it because of their anticholinergic effects. We present the case of a 63-year-old woman, with the diagnosis of histrionic personality disorder, in treatment with quetiapine and venlafaxine. She attended the hospital due to diffuse abdominal pain, diarrhea and hematochezia in the last two days. An abdominal CT scan is made, showing parietal thickening and submucosal edema in the colon, without any tumoral findings, suggesting IC.

Objectives

To point up the correlation between IC and the intake of psychotropic drugs.

Methods

We conducted a narrative review of the literature through the presentation of a case. Articles were selected based on their clinical relevance.

Results

There are reported cases of IC related to antipsychotics, but any drug with anticholinergic effects can potentially cause it. Anticholinergics reduce intestinal motility, leading to colonic ileus and dilatation. Both quetiapine and venlafaxine, taken by the patient, have these effects. Common obstructive and non-obstructive processes are excluded due to the absence of any other pathological signs. For these reasons, the diagnosis of IC secondary to treatment with quetiapine and venlafaxine is made.

Conclusions

Many psychotropic drugs can produce IC owing to their anticholinergic effects, being this chance increased when taken simultaneously with other drugs with same effects. IC is a rare but fatal side effect, which makes it important to consider it in the differential diagnosis in patients in treatment with psychotropics who suffer from gastrointestinal symptoms.

Disclosure

No significant relationships.

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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