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Is MAO-B Activity in Platelets Associated with the Occurrence of Suicidality and Behavioural Personality Traits in Depressed Patients?

Published online by Cambridge University Press:  16 April 2020

U. Lewitzka ,
B. Müller-Oerlinghausen ,
W. Felber ,
E. Lauterbach ,
M. Ising  and
T. Bronisch
U. Lewitzka
Affiliation:
Psychiatry and Psychotherapy, Universtity of Dresden, Dresden, Germany
B. Müller-Oerlinghausen
Affiliation:
Former Research Group Clinical Psychopharmacology, Berlin, Germany
W. Felber
Affiliation:
University of Dresden, Dresden, Germany
E. Lauterbach
Affiliation:
University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany
M. Ising
Affiliation:
Max-Planck-Institute of Psychiatry, Munich, Germany
T. Bronisch
Affiliation:
Max-Planck-Institute of Psychiatry, Munich, Germany

Abstract

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Objective:

Low platelet MAO-B activity has been associated with various forms of impulsive behaviour and suicidality. The present study investigated the relationship between MAO-B activity in platelets and aspects of suicidality in depressed patients and controls.

Method:

In 87 patients with affective spectrum disorders (58% suffering from a Major Depressive Episode - MDE) the potential association between platelet MAO-B activity and suicidality was examined. 59 of the patients had committed suicide attempt recently (SA - “suicide attempters”), 28 patients were acutely depressed without having shown suicidal thoughts or suicidal behaviour in the past (NA - “non suicide attempters”).

Results:

SA and NA were comparable as to their diagnoses and general demographic and psychopathological parameters. MAO-B activity did not differ between SA and NA. No systematic correlations existed between MAO-B activity and any dimensions of suicidal behaviour or psychopathology. As a single finding only a weak positive association of higher MAO-B activity in SA with a fatal intention of the suicide attempt was observed.

Conclusion:

Our findings do not support a consistent association of platelet MAO-B activity and suicidal behaviour in general, but specific facts of suicidality might be associated.

Type
P01-163
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E551
Copyright
Copyright © European Psychiatric Association 2009
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