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Is depression a disorder of a receptor superfamily? A critical review of the receptor theory of depression and the appraisal of a new heuristic model

Published online by Cambridge University Press:  16 April 2020

GB Cassano  and
D Marazziti
GB Cassano
Affiliation:
Institute of Psychiatry and II Chair of Psychiatry, University of Pisa, via Roma 67, 1-56100, Rome, Italy
D Marazziti*
Affiliation:
Institute of Psychiatry and II Chair of Psychiatry, University of Pisa, via Roma 67, 1-56100, Rome, Italy
*
*Correspondance and reprints.
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Summary

The monoamine hypothesis of depression and its direct derivation, the receptor theory, have constituted for several years a frame of reference for researchers working in the field of biological psychiatry. Although most of the data are derived from animal findings and must be considered inconclusive in view of various controversies, some guidelines may be identified: these would suggest that changes in postsynaptic beta-adrenoreceptors, presynaptic alpha 2-adrenoreceptors, as well as in type 2 serotonin receptors and dopaminergic autoreceptors may be involved in the mode of action of antidepressant drugs and, consequently, in the pathophysiology of depression. Nowadays, any attempt to correlate depression with the dysfunction of a single neurotransmitter or receptor is no longer tenable, since it is clear that depression is a heterogeneous disorder which involves abnormalities in the interactive relationships between neurotransmitters and receptors. If, on the one hand, this new model has opened up new fields of research and has led to the investigation of new systems, eg the GABAergic and GABA B receptors, on the other hand, it has been strongly limited by the lack of research tools and reliable peripheral CNS models for in vivo studies. A possible approach to this unresolved dilemma may be provided by molecular biology techniques, which have permitted the identification of the genes and sequencing of the primary structure of several membrane receptors. It is now established that receptors may be grouped into four superfamilies; in depression, there exists compelling evidence of alterations mainly in receptors belonging to the G-protein-coupled family: it is plausible that depression may be related to a disorder of the G-protein-coupled receptor superfamily. Such an hypothesis would represent an attempt to unify the different receptor abnormalities found in depression or following antidepressant treatments, and to shift from the monoamine paradigm to a new heuristic model. In addition, it would accommodate the various dysfunctions likely to be encountered and would open up new theoretical perspectives in the treatment of depression.

Keywords

depressionneuroreceptormolecular biologyG proteinsreceptor superfamily
Type
Review
Information
European Psychiatry , Volume 7 , Issue 6 , 1992 , pp. 259 - 270
Copyright
Copyright © Elsevier, Paris 1992

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References

Abramson, SNShorr, RGLMolinoff, PB (1987) Interactions of beta-adrenergic receptors with a membrane protein other than the stimulatory guanine nucleotidebinding protein. Biochem Pharmacol 36, 2263–2269CrossRefGoogle Scholar
Anderson, IMCowen, PJ (1986) Chlorimipramine enhances prolactin and growth hormone responses to L-tryptophan. Psychopharmacology 89, 131–133CrossRefGoogle ScholarPubMed
Arora, RCMeltzer, HY (1989) Serotonergic measures in brain of suicide victims: 5HT2, binding sites in the frontal cortex of suicide victims and control subjects. Am J Psychiatry 146, 730–736Google Scholar
Åsberg, MTraskman, LThoren, P (1976) 5-HIAA in the cerebrospinal fluid: a biochemical suicide predictor? Arch Gen Psychiatry 33, 1193–1197CrossRefGoogle ScholarPubMed
Ashkenazi, APeralta, EJWinslow, JWRamachandran, JCapon, DJ (1989) Functionally distinct G-proteins selectively couple different receptors to PI hydrolysis in the same cell. Cell 56, 487–493CrossRefGoogle ScholarPubMed
Avissar, SSchreiber, GDanon, ABelmaker, RH (1988) Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex. Nature 331, 440–442CrossRefGoogle ScholarPubMed
Banerjee, SPKung, LSRiggi, SJChanda, SK (1977) Development of beta-adrenergic subsensitivity by antidepressants. Nature 268, 455–456CrossRefGoogle ScholarPubMed
Barbaccia, MLRavizza, LCosta, E (1986) Maprotiline: an antidepressant with an unusual pharmacological profile. J Pharmacol Exp Ther 236, 307–312Google ScholarPubMed
Baudry, MMaitres, MPSchwartz, JC (1976) Modulation of the sensitivity of the noradrenergic receptors in the CNS studied by the responsiveness of the cyclic AMP system. Brain Res 116, 111–124CrossRefGoogle ScholarPubMed
Bauman, PAMaitre, L (1975) Blockade of presynaptic alpha-receptors in rat cortex by antidepressants. Experientia (Basel) 31, 726–730Google Scholar
Beck-Friis, JVon Rosen, DKjelman, BFLjungren, JGWetterberg, L (1984) Melatonin in relation to body measures, sex, age, season, and the use of drugs in patients with major affective disorders and healthy subjects. Psychoneuroendocrinol 9, 261–277CrossRefGoogle ScholarPubMed
Benovic, JLDeBlasi, AStone, WCCaron, MGLefkowitz, RJ (1989) Beta-adrenergic receptor kinase: primary structure delineates a multigene family. Science 246, 235–240CrossRefGoogle ScholarPubMed
Bergstrom, DAKellar, KJ (1979) Effect of electroconvulsive shock on monoaminergic receptor binding sites in rat brain. Nature 278, 464–466CrossRefGoogle ScholarPubMed
Berrettini, WHCappellari, CBNurnberger, JIGershon, ES (1987a) Beta-adrenergic receptors on lymphoblasts: a study of manic-depressive illness. Neuropsychobiol 17, 15–18CrossRefGoogle Scholar
Berrettini, WHBardakjian, JCappellari, CBBarnett, AL jrAlbright, ANurnberger, JIGershon, ES (1987b) Skin fibroblast beta-adrenergic receptor function in manic-depressive illness. Biol Psychiatry 22, 1439–1443CrossRefGoogle Scholar
Birnbaumer, LAbramowitz, JBrown, AM (1990) Receptor-effectors coupling by G-proteins. Biochim Biophys Acta 1031,163–224CrossRefGoogle Scholar
Blackshear, MASteranka, RSanders-Bush, E (1980) Serotonin receptor subtypes after chronic treatment with tricyclic antidepressant drugs. Neurosci Abstr 6, 866Google Scholar
Blatt, CEversole-Cire, PCohn, VH (1988) Chromosomal localization of genes encoding guanine nucleotidebinding protein subunits in mouse and humans. Proc Natl Acad Sci USA 85, 7641–37646CrossRefGoogle Scholar
Blier, PDe Montigny, CChaput, Y (1987) Modification of the 5HT system by antidepressant treatments: implications for the therapeutic response in major depression. J Neurochem 7, 245–255Google Scholar
Bockaert, J (1991) G proteins and G-protein-coupled receptors: structure, function and interactions. Curr Opin Neurobiol 1, 32–42CrossRefGoogle ScholarPubMed
Braddock, LCowen, PJElliott, JMFraser, SStump, K (1986) Binding of yohimbine and imipramine to platelets in depressive illness. Psychol Med 16, 765–773CrossRefGoogle ScholarPubMed
Bryan, LJCole, JJO'Donnell, SRWanstall, JC (1981) A study designated to explore the hypothesis that beta-1 adrenoreceptors are “innervated” receptors and beta-2 adrenoreceptors are “hormonal” receptors. J Pharmacol Exp Ther 207, 446–457Google Scholar
Broekkamp, CJenck, F (1989) The relationship between various animal models of anxiety, fear-related psychiatric symptoms and response to serotonergic drugs.In: Behavioural Pharmacology of 5HT(Bevan, PColls, AArcher, T eds). Hillsdale, NJLawrence Erlbaum Associates, 117– 144Google Scholar
Brown, GLCaroff, SKocsis, JHAmsterdam, JWinokur, AStokes, PEFrazer, A (1985) Nocturnal serum melatonin in major depressive disorders before and after desmethylimipramine treatment. Psychopharmacol Bull 21, 579–581Google ScholarPubMed
Brusov, OSBeliaev, BSKatasonov, ABZlobina GP, Factor, MILideman, RR (1989) Does platelet serotonin receptor sensitivity accompany endogenous depression? Biol Psychiatry 25, 375–381CrossRefGoogle Scholar
Bunney, WEDavis, M (1965) Norepinephrine in depressive reactions. Arch Gen Psychiatry 13, 483–484CrossRefGoogle ScholarPubMed
Bunney, WE JrMurphy, DLGoodwin, FK (1970) The switch process from depression to mania: relationship to drugs which alter brain amines. Lancet i, 1022–1027CrossRefGoogle Scholar
Bunney, WE (1975) The current status of research in the catecholamine theories of affective disorders. Psychopharmacol Commun 1, 599–600Google ScholarPubMed
Carlsson, AShore, PABrodie, BB (1957) Release of 5-hydroxytryptamine from blood platelets by reserpine in vitro. J Pharmacol Exp Ther 120, 334–339Google ScholarPubMed
Castels, SChakrabarti, CWindsberg, BCHurwic, MPerel, JMNyhan, WL (1979) Effect of L-5-hydro Hydroxytryptophan on monoamine and aminoacid turnover in the Lesch-Nyhan syndrome. J Autism Dev Disord 9, 95–98CrossRefGoogle Scholar
Changeaux, JPGiraudet, JDennis, M (1987) The nicotinic acetylcholine receptor: molecular architecture of a ligand-regulated ion channel. Trends Pharmacol Sci 8, 459–465CrossRefGoogle Scholar
Charig, EMAnderson, IMRobinson, JMNutt, DJCowen, PJ (1987) L-tryptophan and prolactin release: evidence for interactions between 5HTIA and 5HT2 receptors. Hum Psychopharmacol 1, 93–97CrossRefGoogle Scholar
Charney, DSMenkes, DBHeninger, GR (1981) Receptor sensitivity and the mechanism of action of antidepressant treatments. Arch Gen Psychiatry 38, 1160–1176CrossRefGoogle Scholar
Charney, DSHeninger, GRSternberg, DEHalstad, KMGiddings, SLandis, DH (1982) Adrenergic receptor sensitivity in depression: effects of clonidine in depressed patients and healthy subjects. Arch Gen Psychiatry 39, 290–294CrossRefGoogle ScholarPubMed
Checkley, SASlade, APShur, E (1981) Growth hormone and other responses to clonidine in patients with endogenous depression. Br J Psychiatry 138, 51–55CrossRefGoogle ScholarPubMed
Chiodo, LAAntelman, SM (1980a) Tricyclic antidepressants induce subsensitivity of presynaptic autoreceptors. Eur J Pharmacol 64, 203–204CrossRefGoogle Scholar
Chiodo, LAAntelman, SM (1980b) Electroconvulsive shock: progressive dopamine subsensitivity independent of repeated treatments. Science 210, 799–801CrossRefGoogle Scholar
Cooper, SJKelly, JCKing, DJ (1985) Adrenergic receptors in depression: effects of electroconvulsive therapy. Br J Psychiatry 1147, 23–27CrossRefGoogle Scholar
Coppen, AGhose, KSwade, CWood, K (1978) Effect Of mianserine hydrochloride on peripheral uptake mechanisms for noradrenaline and 5-hydroxytryptamine in man. Br J Clin Pharmacol 5, 13S–17SGoogle ScholarPubMed
Cowen, PJGreen, ARGrahame-Smith, DGBraddock, LE (1985) Plasma melatonin during desmethylimipramine treatment: evidence for changes in norepinephrine transmission. Br J Clin Pharmacol 19, 799–805CrossRefGoogle Scholar
Cowen, PJCharig, EM (1987) Neuroendocrine response to tryptophan in major depression. Arch Gen Psychiatry 44, 958–966CrossRefGoogle ScholarPubMed
Crews, FTSmith, CB (1978) Presynaptic alphaadrenoreceptor subsensitivity after long-term antidepressant treatments. Science 202, 322–324CrossRefGoogle Scholar
Daiguji, MMeltzer, HTTong, CU'Prichard, DCYoung, MKravitz, H (1981) Alpha-2 adrenergic receptors in platelet membranes of depressed patients: no change in number or 3H-yohimbine affinity. Life Sci 29, 2059–2064CrossRefGoogle ScholarPubMed
Davies, IBSudera, DSagnella, GMarchesi-Saviotti, EMathias, CBannister, ASiever, PS (1982) Increased number of alpha receptors in sympathetic supersensitivity in man. J Clin Invest 69, 779–784CrossRefGoogle ScholarPubMed
Davis, JMKoslow, SHGibson, RD (1988) Cerebrospinal fluid and urinary biogenic amines in depressed patients and healthy controls. Arch Gen Psychiatry 45, 705–711CrossRefGoogle Scholar
Deakin, JFWPennel, I (1986) 5HT receptor subtypes in depression. Psychopharmacol 89, S24Google Scholar
De Montigny, CBlier, P (1985) Electrophysiological aspects of serotonin neuropharmacology: implications for antidepressant treatments.In: Neuropharmacology of Serotonin (Green, AR ed). Oxford University Press, Oxford, 181–195Google Scholar
De Paermentier, FCheetam, SCCrompton, SRHorton, R (1990) Brain beta-adrenoreceptor binding sites in antidepressant-free depressed suicide victims. Brain Res 25, 71–72CrossRefGoogle Scholar
Duman, RSKarbon, EWHarrington, CEnna, SJ (1986) An examination of the involvement of phospolipases 2 and C in the alpha-adrenergic and gammaaminobutyrric acid receptor modulation of cyclic AMP accumulation in rat brain slices. J Biochem 47, 800–810Google Scholar
Enna, SJKarbon, EWDuman, RS (1986) GABA-B agonists and imipramine-induced modifications in rat brain beta-adrenergic receptor binding and function.In: GABA and Mood Disorders (Bartholini, GLloyd, KGMorselli, PL eds). Raven Press, New York, 23–31Google Scholar
Esler, MTurbott, JSchwarz, RLeonard, PBobik, ASkews, HJackman, G (1982) The peripheral kinetics of norepinephrine in depressive illness. Arch Gen Psychiatry 32, 295CrossRefGoogle Scholar
Ferris, RMWhite, HLBooper, BRMaxwell, RATang, FLMBeaman, OJRussel, A (1981) Some neurochemical properties of a new antidepressant, bupropion hydrochloride (Wellbutrin °). Drug Dev Res 1, 21–35CrossRefGoogle Scholar
Fibiger, MCPhillips, AC (1981) Increased intracranial selfstimulation in rats after long-term administration of desipramine. Science 214, 683–685CrossRefGoogle Scholar
Fishman, PHFinberg, JP (1987) Effect of the tricyclic antidepressant desipramine on beta-adrenergic receptors in cultured rat glioma C6 cells. J Neurochem 49, 282–289CrossRefGoogle ScholarPubMed
Friedman, ECooper, TBDallob, A (1983) Effects of chronic antidepressant treatment on serotonin receptor activity in mice. Eur J Pharmacol 89, 69–76CrossRefGoogle ScholarPubMed
Garattini, SSamanin, R (1988) Biochemical hypothesis on antidepressant drugs: a guide for clinicians or a toy for pharmacologists. Psychol Med 18, 287–304CrossRefGoogle ScholarPubMed
Garcia-Sevilla, JAZis, APHollingsworth, P (1981) Platelet alpha-2-adrenergic receptors in major depressive disorders. Arch Gen Psychiatry 138, 1327–1333Google Scholar
Garcia-Sevilla, JAGuimon, JGarcia-Vallejo, PFuster, MJ (1986) Biochemical and functional evidences of supersensitive platelet alpha 2-adrenoreceptors in major affective disorders. Effect of long-term lithium carbonate treatment. Arch Gen Psychiatry 43, 51–57CrossRefGoogle Scholar
Georgotas, AMann, JJBush, D (1980) A clinical trial of zimelidine in depression. Comm Psychopharmacol 4, 71–77Google ScholarPubMed
Gilbert, W (1981) DNA sequencing and gene structure. Science 214, 1305–1312CrossRefGoogle ScholarPubMed
Goodwin, GMDe Souza, RJGreen, AR (1985) Presynaptic 5HT receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive treatment. Nature 317, 531–533CrossRefGoogle Scholar
Goodwin, GMDe Souza, RJGreen, AR (1987) Attenuation by electroconvulsive treatment and antidepressant drugs of the 5HT1A receptor-mediated hypothermia and 5HT syndrome produced by 8-OH-DPTA in the brain. Psychopharmacol 91, 500–505CrossRefGoogle Scholar
Green, ARHeal, DJGoodwin, GM (1986) The effects of antidepressant drugs on monoamine receptors in rodent brain: similarities and differences.In: Antidepressants and Receptor Function. Ciba Foundation Symposium, John Wiley, Chechester, 123, 246–247Google Scholar
Greenspan, KSchildkraut, JJGordon, EKLevy, BKDurell, J (1969) Catecholamine metabolism in affective disorders. Arch Gen Psychiatry 21, 710–716CrossRefGoogle ScholarPubMed
Gudelsky, GAKoening, JIMeltzer, HY (1986) Thermoregulatory responses to serotonin (5HT) receptor stimulation in the rat: evidence for opposing roles of 5HT2 and 5HT1A receptors. Neuropharmacol 25, 1307–1313CrossRefGoogle Scholar
Hall, HSallemark, MRoss, SB (1980) Clenbuterol, a central beta-adrenergic agonist. Acta Pharmacol Toxicol 41, 159–160Google Scholar
Halper, JPBrown, RPSweeney, JAKocsis, JHPeters, AMann, JJ (1988) Blunted beta-adrenergic responsivity of peripheral blood mononuclear cells in endogenous depression. Arch Gen Psychiatry 45, 241–246CrossRefGoogle ScholarPubMed
Hamon, MLaufumey, LEl-Mestikawy, SBorn, CMiquel, MCBolanos, FSchechter, LGozlan, NP (1990) The main features of central 5HT1 receptors. NeuropsychoPharmacol 3, 3498–360Google Scholar
Hancock, AAMarsh, CL (1985) Agonist interactions with beta-adrenergic receptors following chronic administration of desipramine or the atypical antidepressants, iprindole and mianserine. J Recept Res 5, 311–334CrossRefGoogle ScholarPubMed
Hartig, PR (1989) Molecular biology of 5HT receptors. Trends Pharmacol Sci 10, 64–69CrossRefGoogle Scholar
Hartig, PRKao, HTMacchi, MAdhan, NZgombick, JWeinshank, RBranchek, T (1990) The molecular biology of 5HT receptor. An overview. Neuropsychopharmacol 3, 335–337Google Scholar
Healy, DCarney, PALeonard, BE (1983) Monoaminerelated markers of depression. Changes following treatment. J Psychiatry Res 17, 251–260CrossRefGoogle Scholar
Heninger, GRCharney, DSSternberge, DE (1984) Serotonergic function in depression. Arch Gen Psychiatry 41, 398–402CrossRefGoogle ScholarPubMed
Heninger, GCharney, DPrice, LDelgado, PWoods, SGoodman, W (1989) Neuroendocrine effects of serotonin agonists in rhesus monkeys, healthy humans and patients with depression or anxiety disorders: effect of treatments.In: Serotonin: from Cell Biology to Pharmacology and Therapeutics (Paoletti, PVanhoutte, PM eds). Kluwer Academic Press, Dordrecht, The Netherlands, 46–52Google Scholar
Honegger, UEDisler, BWiesmann, UN (1986) Chronic exposure of human cells in culture to the tricyclic antidepressant desipramine reduces the number of betaadrenoreceptors. Biochem Pharmacol 35, 1899–1902CrossRefGoogle Scholar
Kurose, HRegan, JWCaron, MGLefkowitz, RJ (1991) Functional interaction of recombinant alpha 2-adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles. Biochemistry 30, 3335–3341CrossRefGoogle Scholar
Hennings, M (1969) Studies on the mode of action of alpha-methyldopa. Acta Physiol Scand 332SGoogle Scholar
Holcomb, HHBannon, MJRoth, RH (1982) Striatal dopamine autoreceptors uninfluenced by chronic administration of antidepressants. Eur J Pharmacol 82, 173–178CrossRefGoogle ScholarPubMed
Hollister, L (1988) Psychopharmacology: the bridge between psychiatry and psychology. Clin Pharmacol Ther 44 (2), 123–128CrossRefGoogle Scholar
Jimerson, DCInsel, TRReus, VIKoppin, IJ (1983) Increased plasma MHPG in dexamethasone-resistant depressed patients. Arch Gen Psychiatry 40, 173–179CrossRefGoogle ScholarPubMed
Kafka, MSVan Kammen, DPKleinman, JENurnberger, JISiever, LJUhde, TWPolinsky, RJ (1981) Alpha-2 adrenergic receptor function in schizophrenia, affective disorders and some neurological diseases. Commun Psychopharmacol 4, 477–486Google Scholar
Kato, GRBan, A (1984) Neurotransmitters and receptors: clinical implications. Prog NeuropsychopharmacolF & Biol Psychiatry 8, 71–79CrossRefGoogle ScholarPubMed
Koening, JIGudelsky, GAMeltzer, HY (1987) Stimulation of corticosterone and beta-endorphin secretion in the rat by selective 5HT receptor subtype activation. Eur J Pharmacol 137, 1–8CrossRefGoogle Scholar
Koslow, SHMaas, JWBowden, CLDairs, JMHanin, IJavaid, J (1983) CSF and urinary biogenic amines and metabolites in depression and mania. Arch Gen Psychiatry 40, 999–1014CrossRefGoogle ScholarPubMed
Koyama, TMelzer, HY (1987) A biochemical and neuroendocrine study of the serotonergic system in depression.In: New research in Depression (Hippius, H ed) Springer Verlag, Berlin, 169–188Google Scholar
Kuhn, T (1962) The Structure of Scientific Revolution. University of Chicago Press, ChicagoGoogle Scholar
Kupfer, DJBowers, MR jr (1972) Rem sleep and central monoamine oxidase inhibition. Psychopharmacol 27, 182–187CrossRefGoogle ScholarPubMed
Lapin, IPOxenkrug, CG (1969) Intensification of the central 5HTergic processes as a possible determinant of the thymoleptic effect. Lancet i, 136–136Google Scholar
Lesch, PKMayer, SDisselkamp Tietze, JHoh, AWiesman, MOsterherder, MSchultze, HM (1990) 5HT1A receptors responsivity in unipolar depression: evaluation of ipsapirone-induecd ACTH release and Cortisol secretion in patients and controls. Biol Psychiatry 28, 620–628CrossRefGoogle Scholar
Lesch, KP (1991) Modulation of receptor-G protein complex function by psychotropic drugs and glucocorticoids: implications for anxiety disorders and depression. Eur Neuropsychopharmacol 1, 336–343CrossRefGoogle Scholar
Lesch, KPAulakh, CSTolliver, TJHill, JLMurphy, DL (1991) Regulation of G proteins by chronic antidepressant drugs in rat brain: tricyclics but not dorgyline increase Goa subunits. Eur J Pharmacol Mol Sect 207, 361–364CrossRefGoogle ScholarPubMed
Le Fur, GPhan, TUzan, A (1980) Identification of stereospecific 3H-spiroperidol binding sites in mammalian lymphocytes. Life Set 26, 1139–1148CrossRefGoogle ScholarPubMed
Lester, HA (1988) Heterologous expression of excitability proteins: route to more specific drugs? Science 241, 1057–1063CrossRefGoogle ScholarPubMed
Lewy, AJWehr, TAGold, PWGoodwin, FK (1979) Plasma melatonin in manic depressive illness.In: Catecholamines: Basic and Clinical Frontiers II (Usdin, EKopin, IJBarchas, J eds). Pergamon Press, Oxford, 1173–1175CrossRefGoogle Scholar
Lloyd, KGThuret, FPilc, A (1985) Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and elettroshock. J Pharmacol Exp Ther 235, 191–199Google Scholar
Maas, JW (1984) Relationships between central nervous system noradrenergic function and plasma and urinary concentrations of norepinephrine metabolites.In: Frontiers in Biochemical and Pharmacological Research in Depression (Usdin, E ed). Raven Press, New York, 45–55Google Scholar
McCance, SLCowen, PJWaller, JHGrahame-Smith, DG (1988) The effect of metergoline on endocrine response to L-tryptophan. J Psychopharmacol 2, 90–94Google Scholar
McMillan, BAWarnack, WGerman, DCShore, PA (1980) Effect of chronic desipramine treatment on rat noradrenergic responses to alpha-adrenergic drugs. Eur J Pharmacol 61, 3238-240Google Scholar
Maggi, AU'Prichard, DCEnna, SJ (1980) Differential effects of antidepressant treatment on brain monoaminergic receptors. Eur J Pharmacol 61, 91–98CrossRefGoogle ScholarPubMed
Maj, JGorka, ZMelzacka, MRawlow, APilc, A (1983) Chronic treatment with imipramine: further functional evidence for the enhanced noradrenergic transmission in flexor reflex activity. Naunyn Schmiedebergs Arch Pharmacol 322, 256–260CrossRefGoogle ScholarPubMed
Mann, JJBrown, RPHalper, JPSweeney, JAKocsis, JHStokes, PEBilezikian, JP (1985) Reduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitation. N Engl J Med 313, 715–719CrossRefGoogle ScholarPubMed
Mann, JJStanley, MMcBride, APMcEvans, BG (1986) Increased serotonergic and beta adrenergic receptor binding in the frontal cortices of suicide victims. Arch Gen Psychiatry 69, 135–139Google Scholar
Mann, JJMahler, JCWilner, PJBrown, RPJohnson, KSKocsis, JHChen, JS (1990) Normalisation of blunted lymphocyte beta-adrenergic responsivity in melancholic inpatients by a course of electroconvulsive therapy. Arch Gen Psychiatry 47, 461–464CrossRefGoogle Scholar
Marazziti, DPlacidi, GFCassano, GBAkiskal, HS (1989) Lack of specificity of reduced platelet imipramine binding in different psychiatric conditions. Psychiatry Res 30, 21 29CrossRefGoogle ScholarPubMed
Martin, PSoubrie, PSimon, P (1986) Shuttle-box deficits induced by inescapable shock in rats: reversal by the beta-adrenoreceptor stimulants clembuterol and salbutamol. Pharmacol Biochem Behav 24, 177–181CrossRefGoogle Scholar
Matussek, NAckenheil, MHippius, HMuller, FSchroeder, HTHSchultes, HWasilewski, B (1980) Effect of clonidine on growth hormone release in psychiatric patients and controls. Psychiatry Res 2, 25–36CrossRefGoogle Scholar
Maus, MHomburger, VBockaerdt, JGlowinski, JPremont, J (1990) Pretreatment of mouse striatal neurons in primary culture of 17 beta-estradiol enhances the pertussis toxin-catalyzed ADP-ribosylation of G alpha protein subunits. J Neurochem 55, 1244–1251CrossRefGoogle Scholar
Mendels, JFrazer, AFitzgerald, RGRamsey, TAStokes, JW (1972) Biogenic amine metabolities in cerebrospinal fluid of depressed and manic patients. Science 175, 1380–1382CrossRefGoogle Scholar
Meyerson, LRWennogle, LPAbel, MSCoupet, JLip- Pa, ASRau, CEBeer, B (1982) Human brain receptor alterations in suicide victims. Pharmacol Biochem Behav 17, 159–163CrossRefGoogle ScholarPubMed
Minneman, KPDibner, MDWolfe, BBMolinoff, PB (1979) Beta 1 and beta 2-adrenergic receptors in rat cerebral cortex are independently regulated. Science 204, 866–868CrossRefGoogle Scholar
Mishra, PJanowsky, ASulser, F (1980) Action of mianserine and zimelidine on the norepinephrine receptor coupled adenylate cyclase system in brain: subsensitivity without reduction in beta-adrenergic receptor binding. Neuropharmacol 19, 983–991CrossRefGoogle ScholarPubMed
Mobley, PLSulser, F (1981) Down-regulation of the central noradrenergic receptor system by antidepressant therapies: biochemical and clinical aspects.In: Antidepressants: Neurochemical, Behavioral and Clinical Perspectives (Enna, SJMalick, JBRichelson, E eds). Raven Press, New York, 31–51Google Scholar
Moor, MHonegger, UEWeissman, UN (1987) Organospecific qualitative changes in the phospholipid composition of rats after chronic administration of the antidepressant drug, desipramine. Biochem Pharmacol 37, 2035–2039CrossRefGoogle Scholar
Nalepa, IVetulani, J (1991) Different mechanisms of betaadrenoreceptor down-regulation by chronic impramine and electroconvulsive treatment. J Neurochem 57, 904–910CrossRefGoogle Scholar
Nair, NPVHariharasubramanian, NPilapil, CIsaac, IThavundayil, JX (1986) Plasma melatonin, an index of brain aging in humans? Biol Psychiatry 21, 141–150CrossRefGoogle ScholarPubMed
Ninan, PTvan Kammen, DPScheinin, MLinnoila, MBunney, WE JrGoodwin, FK (1984) CSF 5-HIAA in suicidal schizophrenic patients. Am J Psychiatry 141, 566–569Google ScholarPubMed
Okamoto, TKatada, TMuriyama, YOgata, ENishimoto, I (1990) A simple structure encodes G protein activating function of IGF 11 mannose 6-phosphate receptor. Cell 62, 709–717CrossRefGoogle Scholar
Ozawa, HRasenick, MM (1989) Coupling of the stimulatory GTP-binding protein Gs to rat synaptic membrane adenylate cyclase is enhanced subsequent to chronic antidepressant treatment. Mol Pharmacol 36, 803–806Google ScholarPubMed
Palmer, GCRobinson, GASulser, F(1971) Modification by psychotropic drugs of the cyclic adenosine monophosphate response to norepinephrine in rat brain. Biochem Pharmacology 20, 236–239CrossRefGoogle ScholarPubMed
Pandey, GNDysken, MWGarver, DLDavil, JM (1979) Beta-adrenergic receptor function in affective illness. Am J Psychiatry 136, 675–678Google ScholarPubMed
Pandey, GNJanicak, PGDavil, JM (1987) Decreased beta-adrenergic receptors in the leukocytes of depressed patients. Psychiatry Res 22, 265 274CrossRefGoogle ScholarPubMed
Paykel, ESFleminger, RWatson, JP (1982) Psychiatric side effects of antihypertensive drugs other than reserpine. J Clin Psychopharmacol 2, 14–39CrossRefGoogle ScholarPubMed
Peralta, EGAshkenazi, AWinslow, JWSmith, DHRamachandran, JCapon, DJ (1987) Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acethylcholine receptors. EMBO J 6, 3923–3929CrossRefGoogle Scholar
Peroutka, SJSnyder, SH (1980) Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding. Science 210, 88–90CrossRefGoogle ScholarPubMed
Peroutka, SJ (1988) 5HT receptor subtypes: molecular, biochemical and physiological characterization. Trends Pharmacol Sci 11, 496–500Google Scholar
Petrovic, SLMc Donald, JKSnyder, GDMcCann, SM (1983) Characterization of beta-adrenergic receptors in rat brain and pituitary using a new high affinity ligand, l25I-Iodocyanopindolol. Brain Res 261, 249–259CrossRefGoogle Scholar
Pilc, AEnna, SJ (1985) Synergistic interaction between alpha and beta-adrenergic receptors in rat brain slices: possible site for antidepressant drug action. Life Sci 37, 1183–1194CrossRefGoogle ScholarPubMed
Pilc, ALloyd, KG (1984) Chronic antidepressants and GABA B receptors: a GABA hypothesis of antidepressant drug action. Life Sci 35, 2149–2154CrossRefGoogle ScholarPubMed
Pimoule, CBriley, MSGay, CLoo, USZarifian, ERaisman, RLanger, SZ (1983) 3H-rauwolscinc binding in platelets from depressed patients and healthy volunteers. Psychopharmacol 79, 308–312CrossRefGoogle ScholarPubMed
Pletscher, AShore, PABrodie, BB (1955) Serotonin release as a possible mechanism of reserpine action. Science 122, 374–375CrossRefGoogle ScholarPubMed
Post, RMGoodwin, FK (1978) Approaches to brain amines in psychiatric patients: a reevaluation of cerebrospinal fluid studies.In: Handbook of Psychopharmacology (Iversen, LLIversen, SDSnyder, SH eds). Plenum Press, New York, 147–185CrossRefGoogle Scholar
Riblet, LATaylor, DP (1978) Pharmacology of neurochemistry of trazodone. J Clin Psychopharmacol 1 (suppl), 17–22CrossRefGoogle Scholar
Risby, EDHsiac, JKManji, HKBitran, JMoses, FZhou, DFPotter, WZ (1991) The mechanisms of action of lithium. Effects on adenylate cyclase activity and betaadrenergic receptor binding in normal subjects. Arch Gen Psychiatry 48, 513–524CrossRefGoogle Scholar
Roy, APickar, DLinnoila, MPotter, W (1985) Plasma norepinephrine in affective disorders: relationship to melancholia. Arch Gen Psychiatry 42, 1181–1187CrossRefGoogle ScholarPubMed
Rubin, ALPrice, LHCharney, DSHeninger, GR (1985) Noradrenergic function and the Cortisol response to dexamethasone in depression. Psychiatry Res 15, 5–12, 1985CrossRefGoogle ScholarPubMed
Sacchetti, EConte, GPenati, A (1985) Platelet alpha-2-adrenoreceptors in major depression: relationship with 4-hydroxy-3-methoxyphenylglycol and age at onset. J Psychiatric Res 1, 579–586CrossRefGoogle Scholar
Saito, NGuitar, XHayward, MTallman, JFDuman, RSNestler, E (1989) Corticosterone differentially regulates (he expression of Gs alpha and Gi alpha messenger RNA and protein in rat cerebral cortex. Proc Natl Acad Sci USA 86, 3906–3910CrossRefGoogle Scholar
Sanger, F (1981) Determination of nucleotide sequences in DNA. Science 214, 1205–1210CrossRefGoogle ScholarPubMed
Schildkraut, JI (1965) The catecholamine hypothesis of affective illness: a review of supporting evidence. Am J Psychiatry 122, 509–522CrossRefGoogle Scholar
Schildkraut, JJ (1975) Depression and biogenic amines.In: American Handbook of Psychiatry (Hamburg, D ed) Basic Books, New York, 609–672Google Scholar
Schildkraut, JJ (1978) Current status of the catecholamine hypothesis of affective disorders.In: Psychopharmacology: a Generation of Progress (Lipton, MADi Mascio, AKillam, KF eds). Raven Press, New York, 1233–1234Google Scholar
Schmidt, APeroutka, SJ (1989) 5-Hydroxytryptamine receptor families. FASEB 3, 2242–2249CrossRefGoogle ScholarPubMed
Schofield, PShivers, BDSeeburg, PH (1990) The role of receptor subtype diversity in the CNS. Trends Neurosci 13, 8–11CrossRefGoogle Scholar
Schreiber, GAvissar, SDanon, ABelmaker, RH (1991) Hyperfunctional G proteins in mononuclear leukocytes of patients with mania. Biol Psychiatry 29, 273–280CrossRefGoogle ScholarPubMed
Siever, LJUhde, TW (1984) New studies and perspectives on the noradrenergic receptor system in depression: effect of the alpha2-adrenergic agonist clonidine. Biol Psychiatry 19, 287–302Google Scholar
Siever, LJMurphy, DLSlater, Sde la Vega, ELipper, S (1984) Plasma prolactin changes following fenfluramine in depressed patients compared to controls: an evaluation of central serotonergic responsivity in depression. Life Sci 34, 1029–1039CrossRefGoogle ScholarPubMed
Siever, LJ (1987) Role of noradrenergic mechanisms in the etiology of affective disorders.In: Psychopharmacology: the Third Generation of Progress (Meltzer, HY ed). Raven Press, New York, 493–505Google Scholar
Sneddon, JM (1973) Blood platelets as a model for monoamine-containing neurons. Prog Neurohiol 1, 151–198CrossRefGoogle Scholar
Spiegel, AM (1992) Helerotrimeric GTP-binding proteins: an expanding family of signal transducers. Med Res Rev 12, 55–71CrossRefGoogle ScholarPubMed
Stahl, SM (1977) The human platelets. A diagnostic and research tool for the study of biogenic amines in psychiatric and neurological disorders. Arch Gen Psychiatry 34, 509–516CrossRefGoogle Scholar
Stahl, SM (1984) Regulation of neurotransmitter receptors by desipramine and other antidepressant drugs: the neurotransmitter receptor hypothesis of antidepressant action. J Clin Psychiatry 74, 195–206Google Scholar
Stanley, MMann, (1983) Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet i, 349, 214–216CrossRefGoogle Scholar
Sudgen, DKlein, DC (1988) Activators ot protein kinase C act at a postreceptor site to amplify cyclic AMP production in rat pynealocytes. J Neurochem 50, 149–155Google Scholar
Sulser, FVetulani, JMobley, PL (1978) Mode of action of antidepressant drugs. Biochem Pharmacol 27, 257–261CrossRefGoogle ScholarPubMed
Theodoru, AEHale, DSDavies, SLKatona, CLEYamaguchi, YHorton, RWKelly, JSPaykel, ES (1986) Platelet high affinity adrenoreceptor binding sites labelled with the agonist 3H-UK-14,304, in depressed patients and matched controls. Eur J Pharmacol 126, 329–332CrossRefGoogle Scholar
Traskman, LAsberg, MBertilsson, LSjostrand, L (1981) Monoamine metabolites in CSF and suicidal behavior. Arch Gen Psychiatry 38, 631–636CrossRefGoogle ScholarPubMed
U'Prichard, DCGreenberg, DASheehan, PPSnyder, SH (1978) Tricyclic antidepressants: therapeutic properties and affinity for alpha-noradrenergic receptor binding sites in the brain. Science 199, 197–198CrossRefGoogle Scholar
Van Praag, HMAmine hypothesis of affective disorders (1978) In: Handbook of Psychopharmacology (Iversen, LLIversen, SDSnyder, SH eds). Plenum Press, New York, 187–297CrossRefGoogle Scholar
Van Praag, HMDe Haan, S (1979) Central serotonin metabolism and the frequency of depression. Psychiatry Res 1, 219–224CrossRefGoogle Scholar
Vetulani, JSulser, F (1975) Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system. Nature 257, 495–496CrossRefGoogle ScholarPubMed
Vetulani, JStawartz, RSDingell, JVSulser, F (1976) A possible common mechanism of action on antidepressant treatments: reduction in the sensitivity of the noradrenergic cyclic AMP generating system. Naunyn Schmiedeberg's Arch Pharmacol 293, 109–114CrossRefGoogle Scholar
Wachtel, H (1989) Dysbalance of neuronal second messenger function in the aetiology of affective disorders: a pathophysiological concept hypothesising defects beyond first messenger receptors. J Neural Transm 75, 21–29CrossRefGoogle ScholarPubMed
Wang, HLippert, LMalbon, CCBahout, S (1990) Sitedirected anti-peptide antibodies define the topography of the beta-adrenergic receptor. J Biol Chem 264, 14424–14431Google Scholar
Welch, JKim, HFallon, SLiebman, J (1982) Do antidepressants induce dopamine autoreceptor subsensitivity? Nature 298, 301–302CrossRefGoogle Scholar
Wettemberg, LAperia, BBeck-Friis, JKjelmann, BFLjunggren, JGPetterson, USjolin, ATham, A (1981) Pineal-hypothalamic pituitary function in patients with depressive illness.In: Steroid Hormone Regulation of the Brain (Fuxe, KGustaffson, JAWettemberg, L eds). Pergamon Press, Oxford, 397–403CrossRefGoogle Scholar
Wirz-Justice, AArendt, J (1979) Diurnal, menstrual cycle and seasonal indole rhythms in man and their modification in affective disorder.In: Biological Psychiatry Today (Obiols, JBallus, CGonzales, ME eds). Elsevier, Amsterdam, 294–302Google Scholar
Wood, KCoppen, A (1981) Platelet alpha-adrenergic adrenoreceptor sensitivity in depressive illness. Adv Biol Psychiatry 7, 85–89CrossRefGoogle Scholar
Wyatt, RJPortnoy, BKupfer, DJSnyder, FEngelman, K (1971) Resting plasma catecholamine concentrations in patients with depression and anxiety. Arch Gen Psychiatry 24, 65–70CrossRefGoogle ScholarPubMed
Yatani, AImoto, YCodina, JHamilton, SLBrown, AMBirnbaumer, L (1988) The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridinesensitive Ca2+ channels. J Biol Chem 263, 9887–9895Google ScholarPubMed
Zis, APGoodwin, FK (1977) Novel antidepressants and the biogenic amine hypothesis of depression. Arch Gen Psychiatry 36, 1097–1107CrossRefGoogle Scholar
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