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Influence of the Mother’s Emotional State on Infant Irritability is Moderated by the 5-HTTLPR Polymorphism

Published online by Cambridge University Press:  16 April 2020

J. Sanjuan ,
J.L. Ivorra ,
M. Jover ,
J.M. Carot ,
R. de Frutos  and
M.D. Molto
J. Sanjuan
Affiliation:
Valencia University, Valencia, Spain
J.L. Ivorra
Affiliation:
Valencia University, Valencia, Spain
M. Jover
Affiliation:
Clinic Hospital Valencia, Valencia, Spain
J.M. Carot
Affiliation:
Data Analysis Department, Polytechnic University, Valencia, Spain
R. de Frutos
Affiliation:
Valencia University, Valencia, Spain
M.D. Molto
Affiliation:
Valencia University, Valencia, Spain

Abstract

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The serotonin transporter gene-linked polymorphic region (5-HTTLPR) may moderate an individual's response to stress. This study analyzes how the infant 5-HTTLPR may interact with the level of their mother's emotional state to affect infant irritability.

A prospective study was carried out with 314 newborns and their mothers. Infant irritability and the mother emotional state were evaluated at 8 and 32 weeks after childbirth. These variables were correlated with the 5-HTTLPR genotypes of both the infants and their mothers. The irritability score of infants with the s allele of 5-HTTLPR showed a linear relationship with their mother's anxiety at both 8 (P= 0.009) and 32 weeks (P= 0.008). In Infants carrying the ll genotype irritability was independent of their mother's anxiety.

This study provided evidence that the promoter 5-HTTLPR polymorphism could moderate the influence of the mother's anxiety on infant irritability.

Type
S46-02
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E237
Copyright
Copyright © European Psychiatric Association 2009
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