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Increased ventricular cerebrospinal fluid lactate in depressed adolescents

Published online by Cambridge University Press:  23 March 2020

K.A.L. Bradley ,
X. Mao ,
J.A.C. Case ,
G. Kang ,
D.C. Shungu  and
V. Gabbay
K.A.L. Bradley
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place New York, 10029-6574, USA
X. Mao
Affiliation:
Department of Radiology, Weill Cornell Medical College, New York, USA
J.A.C. Case
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place New York, 10029-6574, USA
G. Kang
Affiliation:
Department of Radiology, Weill Cornell Medical College, New York, USA
D.C. Shungu
Affiliation:
Department of Radiology, Weill Cornell Medical College, New York, USA
V. Gabbay*
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place New York, 10029-6574, USA Nathan Kline Institute for Psychiatric Research, Orangeburg, USA
*
*Corresponding author. Tel.: +21 2659 1661; fax: +21 2659 1693. E-mail address: [email protected] (V. Gabbay).
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Abstract

Background

Mitochondrial dysfunction has been increasingly examined as a potential pathogenic event in psychiatric disorders, although its role early in the course of major depressive disorder (MDD) is unclear. Therefore, the purpose of this study was to investigate mitochondrial dysfunction in medication-free adolescents with MDD through in vivo measurements of neurometabolites using high-spatial resolution multislice/multivoxel proton magnetic resonance spectroscopy.

Methods

Twenty-three adolescents with MDD and 29 healthy controls, ages 12–20, were scanned at 3 T and concentrations of ventricular cerebrospinal fluid lactate, as well as N-acetyl-aspartate (NAA), total creatine (tCr), and total choline (tCho) in the bilateral caudate, putamen, and thalamus were reported.

Results

Adolescents with MDD exhibited increased ventricular lactate compared to healthy controls [F(1,41) = 6.98, P = 0.01]. However, there were no group differences in the other neurometabolites. Dimensional analyses in the depressed group showed no relation between any of the neurometabolites and symptomatology, including anhedonia and fatigue.

Conclusions

Increased ventricular lactate in depressed adolescents suggests mitochondrial dysfunction may be present early in the course of MDD; however it is still not known whether the presence of mitochondrial dysfunction is a trait vulnerability of individuals predisposed to psychopathology or a state feature of the disorder. Therefore, there is a need for larger multimodal studies to clarify these chemical findings in the context of network function.

Keywords

Proton magnetic resonance spectroscopyAdolescent depressionMitochondrial dysfunction
Type
Original article
Information
European Psychiatry , Volume 32 , February 2016 , pp. 1 - 8
Copyright
Copyright © European Psychiatric Association 2016

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