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Increased frequency of aberrant CSF circulation in schizophrenic patients compared to healthy volunteers

Published online by Cambridge University Press:  16 April 2020

G Oxenstierna ,
G Bergstrand ,
G Edman ,
L Flyckt ,
H Nybäck  and
G Sedvall
G Oxenstierna
Affiliation:
Department of Clinical Neuroscience, Psychiatry and Psychology Section, Karolinska Hospital, S-17176Stockholm, Sweden
G Bergstrand
Affiliation:
Department of Clinical Neuroscience, Psychiatry and Psychology Section, Karolinska Hospital, S-17176Stockholm, Sweden
G Edman
Affiliation:
Department of Clinical Neuroscience, Psychiatry and Psychology Section, Karolinska Hospital, S-17176Stockholm, Sweden
L Flyckt
Affiliation:
Department of Clinical Neuroscience, Psychiatry and Psychology Section, Karolinska Hospital, S-17176Stockholm, Sweden
H Nybäck
Affiliation:
Department of Clinical Neuroscience, Psychiatry and Psychology Section, Karolinska Hospital, S-17176Stockholm, Sweden
G Sedvall
Affiliation:
Department of Clinical Neuroscience, Psychiatry and Psychology Section, Karolinska Hospital, S-17176Stockholm, Sweden
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Summary

In a previous cisternographic study of the cerebrospinal fluid (CSF) circulation in schizophrenic patients, indications for disturbed flow dynamics were found in 10 of 30 subjects. In order to replicate and investigate the clinical and pathophysiological significance of this finding, 39 schizophrenic patients and 42 healthy subjects were examined with an improved method for measurement of CSF circulation. 99mTc-DTPA was injected intrathecally and the gamma cisternograms were evaluated blindly. Correlations between cisternography findings and age, duration of disease, previous hospitalizations, positive or negative symptomatology, exposure to neuroleptics, psychiatric family history, CT findings and CSF levels of protein, tryptophan and monoamine metabolites, were calculated. Seven of the patients showed abnormalities in the cisternograms with a slow or obstructed flow of CSF over the convexities (P < 0.01) whereas none of the healthy volunteers showed abnormalities. There were no correlations between disturbed CSF circulation in the patients and the clinical and biochemical parameters, thus the significance of the deviations, similar to other biological aberrations found in schizophrenic patients, is not known. Recent developments in magnetic resonance imaging offer new possibilities to further examine CSF circulation abnormalities in schizophrenia.

Keywords

schizophreniaCSF circulationgamma-cisternographyTc-DTPA
Type
Original article
Information
European Psychiatry , Volume 11 , Issue 1 , 1996 , pp. 16 - 20
Copyright
Copyright © 1996 Elsevier, Paris

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References

Andreasen, NCScale for the assessment of negative symptoms (SANS) Iowa CityUniversity of Iowa 1981Google Scholar
Åsberg, MMontgomery, SPerris, CSchalling, DSedvall, GCPRS - the comprehensive psychopathologcal rating scale. Acta Psychiatr Scand 1978; 271: 5–27CrossRefGoogle Scholar
Beck, OHesselgren, Tfor ihe determination of tryptophan in serum and cerebrospinal fluid. J Chromatogr Biomed Applic 1980;181:100–2CrossRefGoogle Scholar
Bergstrand, GOxenstierna, GFlyckt, LLarsson, SASedvall, GRadionuclide cisternography and computed tomography in 30 healthy volunteers. Neuroradiology 1986;28:154–160Google ScholarPubMed
DuBoulay, GO'Connell, JCurie, JBostick, TVerity, PFurther investigations on pulsatile movements in the cerebrospinal fluid pathways. Acta Radiol Diag 1972;13:497–507Google Scholar
Greitz, DNordell, BEricsson, AStÅhlberg, FThomsen, CNotes on the driving forces of the CSF circulation with special emphasis on the piston action of the brain. Neuroradiol 1991;33:178–181Google Scholar
Greitz, DFranck, ANordell, BOn the pulsatile nature of intracranial and spinal CSF-circulation demonstrated by MR imaging. Acta Radiol 1993;34:1–8CrossRefGoogle ScholarPubMed
Larsson, SABergstrand, GBergstedt, HA specially designed cut-off gamma camera for high resolution SPECT of the head J Nucl Med 25 1984;1023–1030Google Scholar
Mathew, NTMeyer, JSHartmann, AOtt, EOAbnormal cerebrospinal fluid-blood flow dynamics. Implications in diagnosis, treatment and prognosis in normal pressure hydrocephalus. Arch Neurol 1975;32:657–664CrossRefGoogle ScholarPubMed
Montgomery, SATayler, PMontgomery, DDevelopment of a schizophrenia scale sensitive to change. Neuropharmacology 1978;17:1061–1063CrossRefGoogle ScholarPubMed
Oxenstierna, GBergstrand, GBjerkenstedt, LSedvall, GWik, GEvidence of disturbed CSF circulation and brain atrophy in cases of schizophrenic psychosis. Br J Psychiatr 1984;144:654–661Google ScholarPubMed
Sedvall, GWode-Helgodt, BAbberrant monoamine metabolite cranial and spinal CSF-circulation demonstrated by MR levels in CSF and family history of schizophrenia. Arch Gen Psychiatry 1980;37:1113–6CrossRefGoogle Scholar
Shelton, RCWeinberger, DRBrain morphology in schizophreniaMeltzer, HYPsychopharmacology: the third generation of progress New YorkRaven Press 1987 773–781Google Scholar
Som, PHosain, FWagner, HNChelated 111. An ideal radiopharmaceutical for cistemography.. Br J Radiol 1972;45:677–9Google Scholar
Spitzer, RLEndicott, JRobins, EResearch Diagnostic Criteria (RDC) for a selected group of functional disorders 3rd ed.New YorkBiometrics Research 1978Google Scholar
Swahn, CGSandgärde, BWiesel, FASedvall, GSimultaneous determination of the three major monoamine metabolites inbrain tissue and body fluids by mass fragmentography.Psychopharmocology 1976;48:147–52CrossRefGoogle Scholar
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