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In vivo measurement of neuronal dopamine transporter in cannabis dependant subjects, with positron tomography and [11C]-PE2I

Published online by Cambridge University Press:  16 April 2020

C. Leroy ,
M. Lukasiewicz ,
C. Trichard ,
C. Comtat ,
R. Trébossen ,
M.J. Ribeiro ,
M. Reynaud  and
J.L. Martinot
C. Leroy
Affiliation:
Institute for Health and Medical Research (INSERM) and Atomic Energy Commission (CEA), Research Unit Neuroimaging in Psychiatry, Research Unit INSERM-CEA U797 Neuroimaging and Psychiatry, Frederic Joliot Hospital Department, Orsay, France
M. Lukasiewicz
Affiliation:
Department of Psychiatry and Addictology, APHP, Paul Brousse Hospital, Villejuif, France
C. Trichard
Affiliation:
Institute for Health and Medical Research (INSERM) and Atomic Energy Commission (CEA), Research Unit Neuroimaging in Psychiatry, Research Unit INSERM-CEA U797 Neuroimaging and Psychiatry, Frederic Joliot Hospital Department, Orsay, France
C. Comtat
Affiliation:
Atomic Energy Commission (CEA), Direction of Life Sciences, Department of Medical Research, Frederic Joliot Hospital, Orsay, France
R. Trébossen
Affiliation:
Atomic Energy Commission (CEA), Direction of Life Sciences, Department of Medical Research, Frederic Joliot Hospital, Orsay, France
M.J. Ribeiro
Affiliation:
Atomic Energy Commission (CEA), Direction of Life Sciences, Department of Medical Research, Frederic Joliot Hospital, Orsay, France
M. Reynaud
Affiliation:
Department of Psychiatry and Addictology, APHP, Paul Brousse Hospital, Villejuif, France
J.L. Martinot
Affiliation:
Institute for Health and Medical Research (INSERM) and Atomic Energy Commission (CEA), Research Unit Neuroimaging in Psychiatry, Research Unit INSERM-CEA U797 Neuroimaging and Psychiatry, Frederic Joliot Hospital Department, Orsay, France

Abstract

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Dopaminergic system within mesocorticolimbic circuit plays a crucial role in addictive behaviors. However, no data to date are available concerning the effect of cannabis addiction on dopaminergic neurotransmisson in humans. The neuronal dopamine transporter (DAT) ensures the regulation of dopaminergic neurotransmission by the re-uptake of extracellular dopamine. Observation of DAT density anomalies within the mesocorticolimbic system in cannabis-dependant subjects could provide further evidence for the implication of dopaminergic dysfunction in cannabis addiction. Thus, this work aims at the study of DAT density in control, tobaccos-dependents subjects and cannabis-dependants subjects, gender and age-paired with Positron Emission Tomography (PET).

Subjects are scanned on High Resolution Research Tomograph (HRRT) for one hour after injection of a selective DAT radioligand ([11C]-PE2I). The binding potential (BP) in regions of interest previously defined within the mesocorticolimbic circuit was calculated using a simplified reference tissue of Lammertsma in order to measure an index of DAT density. BP-obtained in each group: control, tobacco-dependents and cannabis-dependents subjects, were compared with t-tests. Preliminary results will be presented during the seminar.

Type
S06. Symposium: Cannabis Dependence and Abuse: From Neurobiological Understanding to Treatment
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S8
Copyright
Copyright © European Psychiatric Association 2007
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