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Hyperoxia in depression

Published online by Cambridge University Press:  13 August 2021

R. Belmaker ,
Y. Bloch ,
P. Shvartzman ,
P. Romem ,
Y. Bersudsky  and
A. Azab
R. Belmaker*
Affiliation:
Faculty Of Health Science, Ben Gurion University of the Negev, Beersheva, Israel
Y. Bloch
Affiliation:
Faculty Of Health Science, Ben Gurion University of the Negev, Beersheva, Israel
P. Shvartzman
Affiliation:
Faculty Of Health Science, Ben Gurion University of the Negev, Beersheva, Israel
P. Romem
Affiliation:
Faculty Of Health Science, Ben Gurion University of the Negev, Beersheva, Israel
Y. Bersudsky
Affiliation:
Faculty Of Health Science, Ben Gurion University of the Negev, Beersheva, Israel
A. Azab
Affiliation:
Faculty Of Health Science, Ben Gurion University of the Negev, Beersheva, Israel
*
*Corresponding author.

Abstract

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Introduction

Several studies of normobaric hyperoxia in some neurological conditions have demonstrated clinical benefits. Oxygen enriched air may increase oxygen pressure in brain tissue and have biochemical effects such as on brain erythropoietin gene expression, even in patients without lung disease.

Objectives

This pilot, randomized, double-blind study examined the efficacy of normobaric hyperoxia as a treatment for depression.

Methods

Fifty-five consenting patients aged 18-65 years with mild to moderate depression were included in the study. Participants underwent a psychiatric inclusion assessment and a clinical evaluation by a psychiatric nurse at baseline, 2 and 4 weeks after commencement of study intervention. Participants were randomly assigned to normobaric hyperoxia of 35% fraction of inspired oxygen or 21% fraction of inspired oxygen (room air), through a nasal tube, for 4 weeks, during the night. Patients were rated blindly using the Hamilton Rating Scale for Depression (HRSD); Clinical Global Impression (CGI) questionnaire; Sheehan Disability Scale (SDS).

Results

The present study showed a significant improvement in HRSD (p<0.0001), CGI (p<0.01) and in SDS (p<0.05) among patients with depression who were treated with oxygen-enriched air, as compared to patients who were treated with room air. In CGI, 69% of the patients who were treated with oxygen-enriched air improved compared to 23% patients who were treated with room air.

Conclusions

This small pilot study showed a beneficial effect of normobaric hyperoxia on some symptoms of depression.

Disclosure

No significant relationships.

Keywords

oxygenHDRSCGIDepression
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S688 - S689
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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