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Hipersexuality in aripiprazole treatment : A case report

Published online by Cambridge University Press:  01 September 2022

M.V. López Rodrigo*
Affiliation:
Hospital Nuestra Señora del Prado, Psiquiatría, Talavera de la Reina, Spain
M. Palomo Monge
Affiliation:
Hospital Nuestra Señora del Prado, Psiquiatria, Talavera de la Reina, Spain
P. Padilla Romero
Affiliation:
Hospital Universitario insular, Psiquiatría, Las Palmas de Gran Canaria, Spain
A. Osca Oliver
Affiliation:
Hospital Nuestra Señora del Prado, Psiquiatría, Talavera de la Reina, Spain
M. Pérez Fominaya
Affiliation:
Hospital Nuestra Señora del Prado, Psiquiatria, Talavera de la Reina, Spain
*
*Corresponding author.

Abstract

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Introduction

Aripiprazole is an antipsychotic that differs from the group in that it is a partial agonist of the D2 receptor, being also a partial agonist of 5HT1A and an antagonist of 5HT2A.Most antipsychotics cause a decrease in libido, affecting both sexual desire and function. According to the literature, D2 partial agonists can cause the appearance of compulsive behaviors as an adverse effect in 6-24% of patients. Among these behaviors you can find hypersexuality. In most cases, it subsides when treatment is stopped. We describe the case of a patient with bipolar disorder who develops hypersexual behaviors following the aripiprazole treatment. This is a 61-year-old bipolar patient receiving valproate and risperidone. It requires hospital admission due to manic symptoms where dysfunctional tremor is observed. Change from risperidone to aripiprazole. Subsequently, hypersexual behaviors appear, increased libido, obsession with sexual activities (compulsive masturbation with TV programs, mobile applications, cartoons) as well as delusional ideas about “receiving sexual gazes” with no other maniac symptomps.

Objectives

To determine the possibility that hypersexuality was induced by treatment with aripiprazole.

Methods

The appearance in the time line of hypersexuality after the change of treatment would be indicative of causality.

Results

After switching back to risperidone, compulsive sexual behaviors disappear but not the delusional idea of being the focus of sexual gazes by everyone.

Conclusions

Although it is not a common adverse effect, hypersexuality is listed in the literature as a rare adverse effect.

Disclosure

No significant relationships.

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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