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Gene expression profiling of suicide completers

Published online by Cambridge University Press:  16 April 2020

L.M. Fiori  and
G. Turecki
L.M. Fiori
Affiliation:
McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
G. Turecki*
Affiliation:
McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
*
*Corresponding author. Douglas Mental Health University Institute, 6875 LaSalle Boulevard, Verdun, Quebec, Canada, H4H 1R3. Tel.: +1 514 761 6131x2369; fax: +1 514 762 3023. E-mail address: [email protected] (G. Turecki).
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Abstract

Despite strong evidence for a role of biological factors in the etiology and pathology of suicide, the study of traditional neurotransmitter systems has been able to explain only a small proportion of the neurobiology of what is now recognized as a complex genetic trait. The use of microarrays to simultaneously examine the expression levels of thousands of gene transcripts has vastly expanded our capacity to detect the involvement of additional genes and pathways in suicidality, and has opened many new avenues for the discovery of the biological underpinnings of suicide completion. This review examines microarray studies which have been used to identify genes displaying altered expression in suicide completers, and highlights some of the important methodological considerations and metabolic pathways which have emerged from these analyses.

Keywords

SuicideGene expressionMicroarrayGlutamateGABAPolyamines
Type
Original article
Information
European Psychiatry , Volume 25 , Issue 5: The role of genetics in promoting suicide prevention and the mental health of the population - Nobel Conference: The role of genetics in promoting suicide prevention and the mental health of the population , June 2010 , pp. 287 - 290
Copyright
Copyright © Elsevier Masson SAS 2010

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