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Galactorrhea as a side effect of antidepressant drugs. A case report

Published online by Cambridge University Press:  13 August 2021

A.I. Willems Aguado ,
L. Garcia  and
C. Rodriguez
A.I. Willems Aguado*
Affiliation:
Salud Mental, CSM Cangas del Narcea, Cangas del Narcea, Spain
L. Garcia
Affiliation:
Csm Eria, SESPA, Oviedo, Spain
C. Rodriguez
Affiliation:
Csm La Calzada, SESPA, Gijon, Spain
*
*Corresponding author.

Abstract

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Introduction

Galactorrhea wiht antidepressants SSRIs or SNRI is a rarely adverse effect. Some authors believe that the risk of galactorrhea in women who use SSRIs is 8 times higher than in patients treated with other types of drugs. Serotonin is believed to be a potent physiological stimulator of prolactin release.Prolactin stimulates the growth of the mammary glands and the galactorrhea. The SSRIs would activate the serotonergic pathways, these in turn would stimulate the release of prolactin directly in the pituitary and in the hypothalamus, inhibiting the release of dopamine and increasing the release of stimulating factors. The main inhibitor of prolactin secretion is dopamine.

Objectives

The objective is to reveal this rare complication through the report of a clinical case

Methods

A 45-year-old woman with a diagnosis of mixed anxiety-depressive disorder. Treatment with 20 mg of escitalopram was started, with a good therapeutic response, but with breast pain and swelling. She was switched to duloxetine 60 mg, with a good response and adequate tolerance. At 6 months of treatment, she begins to present breast pain and yellow-green breast discharge, with elevated prolactin levels and normal cranial MRI.

Results

She was diagnosed with functional hyperprolactinemia, and treatment with vortioxetine was started. Finally, the Prolactin levels normalize.

Conclusions

Galactorrhea is a very rare and annoying side effect that can lead to discontinuation of treatment and requires a change in the therapeutic strategy.

Disclosure

No significant relationships.

Keywords

galactorrheaside effectscase reportantidepressant drugs
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S775 - S776
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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