The likelyhood of a good symptomatic and functional outcome has varied over time and across place. The most likely explanation is that genetic and environmental factors that influence prognosis vary in a given population at a given time and thus affect disease outcome in that population. Some evidence suggests that outcome may have improved with the introduction of antipsychotics. In some studies better outcome is consistently found in developing compared to developed countries. It has been documented by the WHO International Pilot Study on Schizophrenia. Social-, cultural-, or biologically based differences between countries or even regions may significantly affect the severity of schizophrenia and in a certain way also the level of social functioning of schizophrenic patients.

There are several variables of the outcome of psychosis severity of clinical features, environmental factors (substance use disorders, pre and postnatal factors, etc.), genetic factors, death and disability.

Social functioning (social adaptation) can be measured by various tools - Global Assessment of Functioning Scale or by the level of employment, or the level of employment adequate to education of the patient.

We present a study on first episode patients (N=99) treated either with first or second generation antipsychotics during the period of 12 months after they were discharged from the hospital. All the patients were assessed regularly (0, 3, 6, 9, 12 month) with PANSS, CGI, GAF and the lever of their employment was also taken into account.