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From medication to meditation as treatment for chronic stress and utility of hair cortisol measurement: randomized clinical trial

Published online by Cambridge University Press:  01 September 2022

O. De Juan Viladegut*
Affiliation:
Hospital Clínic de Barcelona, Psychiatry And Psychology, Barcelona, Spain
M. Bioque
Affiliation:
Hospital Clínic de Barcelona, Psychiatry And Psychology, Barcelona, Spain
L. Bueno Sanya
Affiliation:
Hospital Clínic de Barcelona, Psychiatry And Psychology, Barcelona, Spain
H. Andreu Gracia
Affiliation:
Hospital Clínic de Barcelona, Psychiatry And Psychology, Barcelona, Spain
L. Olivier Mayorga
Affiliation:
Hospital Clínic de Barcelona, Psychiatry And Psychology, Barcelona, Spain
*
*Corresponding author.

Abstract

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Introduction

Stress is part of the daily life of many people, especially in Western countries. Recent studies have shown that cortisol has been listed as the primary hormone linked to stress. Currently, to measure cortisol values there are only tests that quantify it at a determined time point, without taking into account its variability and its changing pattern over time, depends on the circadian rhythm and other stress-related factors.

Objectives

This randomized clinical trial of the Hospital Clínic de Barcelona proposes to study the utility of accumulated hair cortisol concentration (HCC) as a measure to correlate the levels of this hormone over time with the stress suffered by the patient.

Methods

Patients are classified into two groups: a control group and an intervention group. In the second group, the participants will follow a mindfulness-based cognitive therapy (MBCT) with the aim of reducing stress and, consequently, cortisol levels.

Results

The purpose of this study is to validate the utility of HCC in order to, retrospectively, obtain cortisol secretion curves as a measure of the level of stress of each individual and personalize the treatments. Simultaneously, we intend to present new perspectives for treatment in psychiatric disorders where stress predominates, such as generalized anxiety disorder (GAD) or major depression (MD), which are becoming increasingly important in our society.

Conclusions

HCC contributes to the practice of personalized medicine as it allows us to detect cortisol exposure in the months prior to obtaining the capillary sample, and thus to draw the trend of this hormone over time.

Disclosure

No significant relationships.

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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