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Fluoxetine seems to widen the nortriptyline antidepressant-like dose range in mice submitted to the tail suspension test (TST)

Published online by Cambridge University Press:  16 April 2020

IR de Oliveira ,
PR Brito ,
MF Peres ,
R Dardennes ,
MA da Rocha-Junior ,
J Gonidec ,
T Rouyer  and
E de Castro-E-Silva
IR de Oliveira*
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI) Laboratório de Neurociências, Departamento de Farmacologia e Fisiologia, ICS, Universidade Federal da Bahia, Vale do Canela, 40140Salvador, Bahia, Brazil
PR Brito
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI)
MF Peres
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI)
R Dardennes
Affiliation:
Clinique de Maladies Mentales et de l'Encéphale, 100 Rue de la Santé, 75014Paris
MA da Rocha-Junior
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI)
J Gonidec
Affiliation:
Laboratoires Delagrange, 1 rue Pierre Brossolete, 91380Chilly-Mazarin, France
T Rouyer
Affiliation:
Laboratoires Delagrange, 1 rue Pierre Brossolete, 91380Chilly-Mazarin, France
E de Castro-E-Silva
Affiliation:
Laboratório de Neurociências, Departamento de Farmacologia e Fisiologia, ICS, Universidade Federal da Bahia, Vale do Canela, 40140Salvador, Bahia, Brazil
*
*Correspondence and reprints: Rua Érico Verissimo, no 340, apt 603, Itaigara, 41850 Salvador, Bahia, Brazi
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Summary

This study was designed to verify whether fluoxetine (FL), a serotonin (5-HT) re-uptake inhibitor, would interfere with nortriptyline (NT), a biphasic U-shaped curvilinear dose-response relationship recently described in our laboratory. We associated 10 mg/kg NT or vehicle to 0, 5, 10, 20 and 40 mg/kg FL, in one group, and 10 mg FL or vehicle to 0, 5, 10, 20 and 40 mg/kg NT, in another group, 30 min before the tail suspension test (TST) in mice. Although we were not able to confirm a synergistic effect between FL and NT, FL-NT association seems to require higher doses of NT to block its own anti-immobility effect at high doses, thus widening NT effective antidepressant-like dose range in mice submitted to TST.

Keywords

fluoxetinenortriptylinemicetail suspension test
Type
Original article
Information
European Psychiatry , Volume 7 , Issue 1 , 1992 , pp. 33 - 37
Copyright
Copyright © Elsevier, Paris 1992

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