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First episode-psychosis: Short- and long-term outcomes and related features predicting the transition to schizophrenia

Published online by Cambridge University Press:  01 September 2022

M. Jabeur ,
L. Gassab ,
S. Boughamoura ,
A. Mhalla ,
F. Zaafrane  and
L. Gaha
M. Jabeur*
Affiliation:
Research laboratory LR 05 ES 10 “Vulnerability to Psychotic Disorders”, Faculty of medicine, University of Monastir, Psychiatry Department, University Hospital Of Monastir, Monastir, Tunisia
L. Gassab
Affiliation:
Research laboratory LR 05 ES 10 “Vulnerability to Psychotic Disorders”, Faculty of medicine, University of Monastir, Psychiatry Department, University Hospital Of Monastir, Monastir, Tunisia
S. Boughamoura
Affiliation:
Research laboratory LR 05 ES 10 “Vulnerability to Psychotic Disorders”, Faculty of medicine, University of Monastir, Psychiatry Department, University Hospital Of Monastir, Monastir, Tunisia
A. Mhalla
Affiliation:
Research laboratory LR 05 ES 10 “Vulnerability to Psychotic Disorders”, Faculty of medicine, University of Monastir, Psychiatry Department, University Hospital Of Monastir, Monastir, Tunisia
F. Zaafrane
Affiliation:
Research laboratory LR 05 ES 10 “Vulnerability to Psychotic Disorders”, Faculty of medicine, University of Monastir, Psychiatry Department, University Hospital Of Monastir, Monastir, Tunisia
L. Gaha
Affiliation:
Research laboratory LR 05 ES 10 “Vulnerability to Psychotic Disorders”, Faculty of medicine, University of Monastir, Psychiatry Department, University Hospital Of Monastir, Monastir, Tunisia
*
*Corresponding author.

Abstract

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Introduction

The occurrence of a first episode-psychosis in adolescents or young adults represents a difficult struggle with an uncertain and divergent outcome, since the clinician does not have at his disposal the clinical elements sufficient to predict these different disease trajectories.

Objectives

Our aims are to describe the socio-demographic, clinical characteristics and the short and long-term outcomes of a first episode-psychosis and to identify the predictive factors of the transition to schizophrenia.

Methods

We conducted a retrospective study about 117 patients hospitalized for a first episode-psychosis in the Psychiatric Department of Monastir (Tunisia). Sociodemographic and clinical features were collected using a pre-established form.

Results

First-episode psychosis affected young male subjects with low educational level. Stressors were present in 54.7%. An 8-week prodromal phase preceded the onset of the disorder in 59%. The disorder course included diagnosis of: Brief psychotic disorder (32.5%), schizophrenia (31.6%) and bipolar disorder (18.8%). The short-term outcome was characterized by a complete remission rate of 58.1% at 3 months and 37.6% at 6 months. The long-term outcome was marked by a high rate of lost to follow-up: 70.8% after 5 years. The transition to schizophrenia was linked to the presence of delirium of influence and the absence of favorable course at 3 months.

Conclusions

Our results led to the identification of the profile of patients with a first episode-psychosis and the factors correlated with a diagnosis of schizophrenia. Indeed, the determination of risk factors would make it possible to adapt earlier the care.

Disclosure

No significant relationships.

Keywords

First-episode psychosisschizophréniarisk factorsoutcome
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S779
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Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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