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FC02-06 - Correlations between nucleus lentiformis asymmetry parameters (MRI data) and memory characteristics (semantic aspect) in patients with schizophrenia

Published online by Cambridge University Press:  16 April 2020

D. Murtazaeva ,
T. Savina ,
V. Orlova ,
V. Kornienko  and
N. Arutiunov
D. Murtazaeva
Affiliation:
Centre of Magnetic Resonance Tomography and Spectroscopy, Moscow State University, Russia
T. Savina
Affiliation:
Mental Health Research Centre, RAMS, Moscow, Russia
V. Orlova
Affiliation:
Mental Health Research Centre, RAMS, Moscow, Russia
V. Kornienko
Affiliation:
Bourdenko Neurosurgery Institution, RAMS, Moscow, Russia
N. Arutiunov
Affiliation:
Bourdenko Neurosurgery Institution, RAMS, Moscow, Russia

Abstract

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Introduction

It's evident that abnormalities of subcortical brain structures asymmetry are related with schizophrenia pathogenesis.

Objectives

Basal ganglia participate in memory processes. Estimation of relationship between their asymmetry parameters and memory characteristics should be examined.

Aims

To investigate correlations between nucleus lentiformis (NL) MRI parameters and memory peculiarities (semantic aspect) in schizophrenia 96 patients and 51 controls were examined.

Methods

3D MR images were acquired on magnet 0.5 Tomikon S50, Bruker (69 patients‘and 34 controls‘groups) and 1.5T GE Signa System (27 patients‘and 17 controls‘groups). Volumes (V) of left and right NL and their asymmetry coefficients (2 x (right NLV- left NLV) x 100/ (right NLV+left NLV),%) were calculated.

Psychological pictogram method1,2 estimating mnestic activity including semantic aspect was used. Quantitative (retention productivity score (RPS) was analyzed.

Results

Decreasing of the right (more prominent, p = 0.046, p = 0.044) and left NL (p = 0.048, p = 0.048) volumes were demonstrated in both patients groups. The RPS was less in both patients groups as compared with controls (p < 0.01). Correlation between NL asymmetry coefficients and RPS was revealed in patients underwent 0.5 and 1.5T scanners (r = -0.51, p < 0.05; r = - 0.57, p < 0.05 correspondingly).

Conclusions

The data confirm significance of brain asymmetry and memory dysfunction in etiology of schizophrenia.

Type
Research Article
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 1820
Copyright
Copyright © European Psychiatric Association 2011

References

Leontiev, A.N.Mediated retention in children with intellect reduced and changed by the disease. Questions of dialectology 1928; 4: 15–27Google Scholar
Luria, A.R.Memory. Moscow Fundamentals of neuropsychology4 ed2006 Center “Academy” 276293Google Scholar
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