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A family study of obsessive compulsive, eating and mood disorders

Published online by Cambridge University Press:  16 April 2020

L Pasquale ,
G Sciuto ,
S Cocchi ,
P Ronchi  and
L Bellodi
L Pasquale
Affiliation:
Department of Neuropsychiatries Sciences
G Sciuto
Affiliation:
Department of Neuropsychiatries Sciences
S Cocchi
Affiliation:
Department of Neuropsychiatries Sciences
P Ronchi
Affiliation:
Department of Neuropsychiatries Sciences
L Bellodi
Affiliation:
Divisione di Psichiatria 2, Cattedra di Psicopathologia, School of Medicine, University of Milan, S Raffaele Hospital, 29 via Prinetti, Milan20127, Italy
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Summary

We calculated Morbidity Risks (MR%) for the major psychiatric conditions in the families of three groups of patients, affected by Eating Disorders (ED; n = 41), Obsessive Compulsive Disorder (OCD; n = 70) and Mood Disorders (MD; n = 39). Our aim was to verify the hypothesis of a common familial pattern of aggregation. Familial risk of developing OCD was significantly increased in the families of OCD probands. Homotypic cases were also augmented in ED and MD families with respect to the rates of the general population, although without statistical significance in the crosswise comparisons. These results confirm the existence of a genetic susceptibility to the development of OCD.

Keywords

obsessive compulsive disordereating disordersmood disordersmorbidity riskgenetic epidemiology
Type
Original article
Information
European Psychiatry , Volume 9 , Issue 1 , 1994 , pp. 33 - 38
Copyright
Copyright © Elsevier, Paris 1994

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References

American Pyschiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 3rd edn Revised (DSM III-R). Washington: APA, 1987Google Scholar
Andreasen, NCEndicott, JSpitzer, RLWinoukur, J. The family history method using diagnostic criteria: reliability and validity. Arch Gen Psychiatry 1977;34:1229–35CrossRefGoogle ScholarPubMed
Bellodi, LPasquale, LDiaferia, GSciuto, GBernardeschi, LCocchi, S. Do Eating, Mood and Obsessive Compulsive patients share a common personality profile? N Trends Exp Clin Psychiatry, 1992;3Google Scholar
Bellodi, LSciuto, GDiaferia, GRonchi, PSmeraldi, E. Psychiatric disorders in the families of patients with obsessive compulsive disorder. Psychiatry Res 1992;42:11–120CrossRefGoogle ScholarPubMed
Di Nardo, PABarlow, DH. Syndrome and symptom co-occurence in the anxiety disorders.In: Maser, JDCloninger, CR eds. Comorbidity of Mood and Anxiety Disorders. Am Psychiatric Press Inc:1984;12:205–30Google Scholar
Du Bois, F. Compulsion Neurosis with Cachexia. Am J Psychiatry 1949;106–7Google Scholar
Gasperini, MBattaglia, MScherillo, PSciuto, GDiaferia, GBellodi, L. Morbidity Risk for mood disorders in the families of borderline patients. J Affect Disord 1991;21:265–72CrossRefGoogle ScholarPubMed
Hudson, JIPope, HGJonas, JMYurgelul-Todd, D. Family history study of anorexia nervosa and bulimia. Br J Psychiatry 1983;142:133–8CrossRefGoogle ScholarPubMed
Insel, TRDonnelly, EFLalakea, MLAlterman, ISMurphy, DL. Neurological and neuropsychological studies of patients with obsessive-compulsive disorder. Biol Psychiatry 1983;18:741–51Google ScholarPubMed
Insel, TRMueller, EAGillin, JCSiever, LJMurphy, DL. Biological markers in obsessive-compulsive disorder. J Psychiatry Res 1984;18:407–23CrossRefGoogle Scholar
Kendler, KSMcLean, CNeale, MKessler, RHeath, APhil, DEaves, L. The genetic epidemiology of bulimia nervosa. Am J Psychiatry 1991;48:1627–37Google Scholar
Marcus, SBuke, SMcEvoy, Let al. NIMH Diagnostic Interview Schedule. Data entry and verification. version 1.0 program. Washington: Washington University, 1990Google Scholar
Marks, IM. Fears, phobias and rituals. Oxford: Oxford University Press, 1987Google Scholar
McKeon, PMurry, R. Familial aspects of obsessive compulsive neurosis. Br J Psychiatry 1987;151:528–34CrossRefGoogle ScholarPubMed
Monteiro, WMarks, IMNoshirvani, H. Normal dexamethasone suppression test in obsessive-compulsive disorder. Br J Psychiatry 1986;148:326–9CrossRefGoogle ScholarPubMed
Palmer, HJones, M. Anorexia Nervosa, the manifestation of compulsive neurosis: a study of psychogenic factors. Arch Neurol Psychiatry 1939;41:856Google Scholar
Rasmussen, SATsuang, MT. Epidemiology of obsessive-compulsive disorder. A review. J Clin Psychiatry 1984;45:450–7Google Scholar
Rasmussen, SATsuang, MT. Clinical characteristics and family history in DSM III obsessive compulsive disorder. Am J Psychiatry 1984;143:317–22Google Scholar
Robins, LHelzer, JCottier, L. NIMH Diagnostic Interview Schedule. Version III-R (DIS III-R). St Louis:Washington University School of Medicine, 1989Google Scholar
Robins, LNHelzer, JEWeissman, MOrvaschel, HGruenberg, ERegier, A. Lifetime prevalence of specific psychiatric disorders in three sites. Arch Gen Psychiatry 1984;41:949–58CrossRefGoogle ScholarPubMed
Smeraldi, EGasperini, MMacciardi, FBussoleni, C. Factors affecting the distribution of age at onset in patients with affective disorders. J Psychiatry Res 1983;17,3:309–17CrossRefGoogle Scholar
Solyom, LFreeman, RJMiles, JE. A comparative psychometric study of Anorexia Nervosa and obsessive neurosis. Can J Psychiatry 27:282–6CrossRefGoogle Scholar
Strober, Met al. Validity of the bulimia-restrictec distinction in anorexia nervosa; parents personality characteristics and family psychiatric morbidity. J Nerv Ment Dis 1987;170:345–51CrossRefGoogle Scholar
Weissman, MGershon, ESKidd, Ket al. Psychiatric Disorders in the relatives of probands with affective disorders. Arch Gen Psychiatry 1984;41:13–21CrossRefGoogle ScholarPubMed
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