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Family history of mood disorders and concomitant psychopathology in patients with depression

Published online by Cambridge University Press:  13 August 2021

E. Kasyanov ,
A. Nikolishin ,
G. Rukavishnikov ,
A. Kibitov  and
G. Mazo
E. Kasyanov*
Affiliation:
Department Of Translational Psychiatry, V. M. Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Petersburg, Russian Federation
A. Nikolishin
Affiliation:
Laboratory Of Molecular Genetics, Serbsky National Medical Research Center on Psychiatry and Addictions, Moscow, Russian Federation
G. Rukavishnikov
Affiliation:
Department Of Translational Psychiatry, V. M. Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Petersburg, Russian Federation
A. Kibitov
Affiliation:
Laboratory Of Molecular Genetics, Serbsky National Medical Research Center on Psychiatry and Addictions, Moscow, Russian Federation
G. Mazo
Affiliation:
Department Of Translational Psychiatry, V. M. Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Petersburg, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

A family history (FH) of mood disorders is an important clinical feature that affects the risk of depression and its clinical manifestations during the course of the disease.

Objectives

To assess the impact of FH in patients with depression on the presence of concomitant psychiatric disorders.

Methods

This cross-sectional study included 172 patients with depression (64.5% women; age - 40,87±15,86 years). The M.I.N.I. was conducted to verify the diagnosis of psychiatric disorders. FH is based on indirect reports of patients.

Results

The most prevalent concomitant psychiatric diagnoses in patients with depression were generalized anxiety disorder (GAD; 26,2%), panic disorder (24,4%) and social anxiety disorder (13,4%). FH was recorded in 52 (30.2%) patients with depression. Patients with depression and FH more often had concomitant GAD (with FH - 20 (38,5%), without FH - 25 (20,8%); p=0.016). Women with depression and FH showed a higher rate of early onset (before age 18) of depression (with FH - 10 (32,3%), without FH - 10 (12,5%); p=0.015). Men with depression and FH more often had concomitant GAD (with FH - 10 (47,6%), without FH - 8 (20%); p=0.025). Logistic regression revealed that FH was associated with GAD in patients with depression (p=0.019).

Conclusions

FH of mood disorders in patients with depression is associated with specific concomitant psychopathology. Further genetic studies are needed to explain this comorbidity.

Keywords

Depressionanxietyfamily history
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S338
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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