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Factors associated with depression in Parkinson’s disease: a cross-sectional study in a Polish population

Published online by Cambridge University Press:  16 April 2020

Hubert M. Wichowicz ,
Jarosław Sławek ,
Mirosława Derejko  and
Wiesław Jerzy Cubała
Hubert M. Wichowicz*
Affiliation:
1st Department of Psychiatry, Medical University, Gdańsk, Dębinki 7 St.80-952Gdańsk, Poland
Jarosław Sławek
Affiliation:
Department of Neurosurgery, Division of Functional Surgery and Movement Disorders, Medical University, Gdańsk, Poland
Mirosława Derejko
Affiliation:
Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland
Wiesław Jerzy Cubała
Affiliation:
1st Department of Psychiatry, Medical University, Gdańsk, Dębinki 7 St.80-952Gdańsk, Poland
*
*Corresponding author. Tel.: +48 58 349 2650; fax: +48 58 349 2748. E-mail address: [email protected] (H.M. Wichowicz).
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Abstract

Objective

The aim of this study was to assess the prevalence and factors influencing depression in PD patients in a cross-sectional outpatient clinic - based Polish patients sample.

Materials and methods

One hundred consecutive PD patients were included in this study; 35 of them fulfilled DSM-IV criteria for Major Depression and its severity was assessed with Montgomery–Asberg Depression Rating Scale (MADRS). A structured interview and a neurological examination, including Hoehn and Yahr scale (H–Y), Schwab–England disability scale, II, III, IV parts of Unified Parkinson's Disease Rating Scale (UPDRS), and Mini-Mental State Examination (MMSE) were performed. The parameters obtained were analysed between the depressed and non-depressed PD patients.

Results

The prevalence of depression in PD in Polish population was established at the level of 35%. PD patients with depression scored significantly higher in all UPDRS scales (except for the subscale of clinical fluctuation) and in H–Y scale. PD with depression was also associated with longer PD duration, higher doses of L-dopa equivalents, patients' age, general impairment of daily living in Schwab and England disability scale, lower MMSE and higher clinical fluctuations. However, those six differences were insignificant.

Conclusions

Depression prevalence rate among PD patients in Polish population is slightly lower than in most of other published studies. This may result from strict selection criteria, use of specific outcome measures and restricted criteria for depression that were applied.

Keywords

Parkinson’s diseaseDepressionComorbidity
Type
Original article
Information
European Psychiatry , Volume 21 , Issue 8 , December 2006 , pp. 516 - 520
Copyright
Copyright © Elsevier Masson SAS 2006

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References

Aarsland, D., Cummings, J.Depression in Parkinson's disease Act. Psychiatr. Scand. 2002; 106:161–162.CrossRefGoogle ScholarPubMed
Allain, H., Schuck, S., Mauduit, N.Depression in Parkinson's disease BMJ 2000; 320:1287–1288.CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington DC: APA; 1994.Google Scholar
Broks, D.J., Doder, M.Depression in Parkinson disease Curr. Opin. Neurol. 2001; 14:465–470.CrossRefGoogle Scholar
Brown, R.G., MacCarthy, B.Psychiatric morbidity in patients with Parkinson’s disease Psychol. Med. 1990; 20:77–87.CrossRefGoogle ScholarPubMed
Brown, R.G., MacCarthy, B., Gotham, A.M., Der, G.J., Marsden, C.D.Depression and disability in Parkinson’s disease: a follow-up study of 132 cases Psychol. Med. 1988; 18:49–55.CrossRefGoogle ScholarPubMed
Brown, G.L., Wilson, W.P.Parkinsonism and depression South. Med. J. 1972; 65:540–545.CrossRefGoogle ScholarPubMed
Celesia, G.S., Wanamaker, W.M.Psychiatric disturbances in Parkinson disease Dis. Nerv. Syst. 1972; 33:577–583.Google Scholar
Cummings, J.L.Depression and Parkinson disease: a review Am. J. Psychiatry 1992; 149:443–454.Google ScholarPubMed
Dooneief, G., Mirabello, E., Bell, K., Marder, K., Stern, Y., Mayeux, R.An estimate of the incidence of depression in idiopathic Parkinson’s disease Arch. Neurol. 1992; 49:305–307.CrossRefGoogle ScholarPubMed
Ehmann, T.S., Beninger, R.J., Gawel, M.J., Riopelle, R.J.Depressive symptoms in Parkinson’s disease: a comparison with disabled control subjects J. Geriatr. Psychiatr. Neurol. 1990; 2:3–9.CrossRefGoogle Scholar
El-Awar, M., Freedman, M., Seeman, P., Goldenberg, L., Little, J., Solomon, P.Response of tardive and L-dopa-induced dyskinesias to antidepressants Can. J. Neurol. Sci. 1987; 14:629–631.Google Scholar
Fahn, S., Elton, R.L.Members of the UPDRS Development Committee. Unified Parkinson’s disease rating scale. Fahn, S., Marsden, C.D., Calne, D.B., Recent Developments in Parkinson’s Disease Florham Park, NJ: Mac Millan Healthcare Information; 1987. 153–156.Google Scholar
Folstein, M.F., Folstein, S.E., Mc Hugh, P.R.Mini-mental state. A practical method for grading the cognitive state of patients for the clinician J. Psychiatr. Res. 1975; 12:189–198.CrossRefGoogle Scholar
Friedenberg, D.L., Cummings, J.L.Parkinson’s disease, depression, and the on-off phenomenon Psychosomatics 1989; 30:94–99.CrossRefGoogle ScholarPubMed
Gotham, A.M., Brown, R.G., Marsden, C.D.Depression in Parkinson’s disease: a quantitative and qualitative analysis J. Neurol. Neurosurg. Psychiatry 1986; 49:381–389.CrossRefGoogle ScholarPubMed
Hoehn, M.M., Yahr, M.D.Parkinsonism: onset, progression and mortality Neurology 1967; 17:427–442.CrossRefGoogle ScholarPubMed
Horn, S.Some psychological factors in parkinsonism J. Neurol. Neurosurg. Psychiatry 1974; 37:27–31.CrossRefGoogle ScholarPubMed
Hughes, A.J., Daniel, S.E., Kilford, L., Lees, A.J.Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinicopathological study of 100 cases J. Neurol. Neurosurg. Psychiatry 1992; 51:745–752.Google Scholar
Lauterbach, E.C., Sethi, K.D.Differential correlates of mood and cognition in dystonia and Parkinson’s disease Mov. Disord. 17(suppl 5)2002 S223.Google Scholar
Leentjens, A., Verhey, F., Lousberg, R., Spitsbergen, H., Wilmink, F.The validity of Hamilton and Montgomery-Asberg depression rating scale and diagnostic tools for depression in Parkinson’s disease Int. J. Geriatr. Psychiatry 2000; 15:644–649.3.0.CO;2-L>CrossRefGoogle ScholarPubMed
Maricle, R.A., Nutt, J.G., Carter, J.H.Mood and anxiety fluctuation in Parkinon’s disease associated with levodopa infusion: Preliminary findings Mov. Disord. 1995; 10:329–332.CrossRefGoogle Scholar
Mayeux, R., Yaakov, B.A., Rosen, J., Leventhal, J.Depression, intelectual impairment and Parkonson disease Neurology 1981; 31:645–650.CrossRefGoogle Scholar
McDonald, W.M., Richard, I.H., DeLong, M.R.Prevalance, Etiology, and Treatment of Depression in Parkinson’s Disease Biol. Psychiatry 2003; 54:363–375.CrossRefGoogle Scholar
Mindham, R.H.S.Psychiatric symptoms in parkinsonism J. Neurol. Neurosusrg. Psychiatry 1970; 33:188–191.CrossRefGoogle ScholarPubMed
Mindham, R.H.S., Marsden, C.D., Parkes, J.D.Psychiatric symptoms during l-dopa therapy for Parkinson’s disease and their relationship to physical disability Psychol. Med. 1976; 6:23–33.CrossRefGoogle ScholarPubMed
Montgomery, S.A., Asberg, M.A new depression scale designed to be sensitive to change Br. J. Psychiatry 1979; 134:322–389.CrossRefGoogle ScholarPubMed
Nissenbaum, H., Quinn, N.P., Brown, R.G., Toone, B., Gotham, A.M., Marsden, C.D.Mood swing associated with the “on-off” phenomenon in Parkinson’s disease Psychol. Med. 1987; 17:899–904.CrossRefGoogle Scholar
Poewe, W., Luginger, E.Depression in Parkinson’s disease: impediments to recognition and treatment options Neurology 52(Suppl.3)1999 S2–S6.Google ScholarPubMed
Racette, B.A., Hartlein, J.M., Hershey, T., Mink, J.W., Perlamuter, J.S., Black, K.J.Clinical features and comorbidity of mood fluctuations in Parkinson’s disease J. Neuropsychiatry Clin. Neurosci. 2002; 14:438–442.CrossRefGoogle ScholarPubMed
Ranoux, D.Depression et maladie de Parkinson. Encephale 26 (Spec 3): 22–26.Google Scholar
Richard, I.H., Justus, A.W., Kurlan, R.Relationship between mood and motor fluctuations in Parkinson’s disease J. Neuropsychiatry Clin. Neurosci. 2001; 13:35–41.CrossRefGoogle ScholarPubMed
Santamaria, J., Tolosa, E., Valles, A.Parkinson’s disease with depression: a possible subgroup of idiopathic parkinsonism Neurology 1986; 36:1130–1133.CrossRefGoogle ScholarPubMed
Schrag, A., Hahanshahi, M., Quinn, N.How does Parkinson’s Disease affect quality of life? A comparison with quality of life in the general population Mov. Disord. 2000; 6:1112–1118.3.0.CO;2-A>CrossRefGoogle Scholar
Schwab, R.S., England, A.C.Projection technique for evaluating surgery in Parkinson’s disease. Gillingham, F.J., Donaldson, I.M.L., Third Symposium on Surgery in Parkinson’s Disease. Edinburgh: Livingstone; 1969. 152–157.Google Scholar
Slawek, J., Derejko, M., Lass, P.Factors affecting the quality of life of patients with idiopathic Parkinson’s disease-a cross-sectional study in an outpatient clinic attendees Parkinsonism Relat. Disord. 11(7)2005 465–468.CrossRefGoogle Scholar
Starkstein, S.E., Preziosi, T.J., Bolduc, P.L., Robinson, R.G.Depression in Parkinson’s disease J. Nerv. Ment. Dis. 1990; 178:27–31.CrossRefGoogle ScholarPubMed
Starkstein, S.E., Mayberg, H.S., Leiguarda, R., Preziosi, T.J., Robinson, R.G.A prospective longitudinal study of depression, cognitive decline, and physical impairments in patients with Parkinson’s disease J. Neurol. Neurosurg. Psychiatry 1992; 55:377–382.CrossRefGoogle ScholarPubMed
Tandberg, E., Larsen, J.P., Aarsland, D., Laake, K., Cummings, J.L.The occurrence of depression in Parkinson’s disease. A community-based study Arch. Neurol. 1996; 53:175–179.CrossRefGoogle ScholarPubMed
Zach, M., Friedman, A., Slawek, , J, , Derejko, , M, Quality of life in Polish patients with long-lasting Parkinson’s disease Mov. Disord. 19(6)2004 667–672.CrossRefGoogle ScholarPubMed
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