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Evaluation of Cognitive Dysfunction in a Sample of Patients Affected by Bipolar Disorder

Published online by Cambridge University Press:  23 March 2020

E. Stella ,
M. La Montagna ,
L. Borraccino ,
F. Ricci ,
A.I. Triggiani ,
F. Panza ,
D. Seripa ,
G. Miscio ,
A. Bellomo  and
M. Lozupone
E. Stella
Affiliation:
University of Foggia, Psychiatric Unit, SPDC, Department of Mental Health Asl Fg, Foggia, Italy
M. La Montagna
Affiliation:
University of Foggia, Psychiatric Unit, SPDC, Department of Mental Health Asl Fg, Foggia, Italy
L. Borraccino
Affiliation:
University of Foggia, Psychiatric Unit, SPDC, Department of Mental Health Asl Fg, Foggia, Italy
F. Ricci
Affiliation:
University of Foggia, Psychiatric Unit, SPDC, Department of Mental Health Asl Fg, Foggia, Italy
A.I. Triggiani
Affiliation:
Laboratory of Physiology, University of Foggia, Department of Clinical and Experimental Medicine, Foggia, Italy
F. Panza
Affiliation:
IRCCS Casa Sollievo della Sofferenza, Department of Medical SciencesSan Giovanni RotondoItaly
D. Seripa
Affiliation:
IRCCS Casa Sollievo della Sofferenza, Department of Medical SciencesSan Giovanni RotondoItaly
G. Miscio
Affiliation:
IRCCS Casa Sollievo della Sofferenza, Department of Medical SciencesSan Giovanni RotondoItaly
A. Bellomo
Affiliation:
University of Foggia, Psychiatric Unit, SPDC, Department of Mental Health Asl Fg, Foggia, Italy
M. Lozupone
Affiliation:
University of Foggia, Psychiatric Unit, SPDC, Department of Mental Health Asl Fg, Foggia, Italy

Abstract

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Introduction

Cognitive dysfunctions concerning working memory, attention, psychomotor speed, and verbal memory are a disabling feature of the bipolar disorder (BD). According to scientific literature, cognitive disturbances are present not only in depressive and manic phases of BD, but also during the euthymic period, without regard to whether or not drugs are assumed.

Objective

To determine the presence of one or more dysfunctions in cognitive domains in a sample of subjects suffering from BD, in euthymic phase, compared with healthy controls.

Aims

Evaluation of the following cognitive performances in subjects affected by BD: speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition.

Methods

Forty-six patients affected by BD in the euthymic phase (mean age: 43.17 years old; 39.13% male), and 58 healthy controls (mean age: 39.21 years old; 51.72% male) were enrolled in the psychiatric unit of Azienda Sanitaria Locale, Foggia. The neuropsychological battery MATRICS Consensus Cognitive Battery (MCCB) was administered by trained psychiatrists.

Results

We found the presence of cognitive impairment, affecting six out of seven of cognitive functions assessed (P < 0.001): speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving.

Conclusions

These preliminary results from our case-control study show that cognitive deficits are clearly present also during the euthymic phases of subjects with bipolar disorder (mainly pertaining attention/vigilance domain). These cognitive abnormalities may represent a biomarker of bipolar disorder.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-poster walk: Bipolar disorders – Part 2
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S212
Copyright
Copyright © European Psychiatric Association 2017
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