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Estradiol and Progesterone as key modulators of central systems implicated in schizophrenia

Published online by Cambridge University Press:  01 September 2022

A. Ruiz-Tristan ,
C. Rivera-Clemente ,
V. Gomez-De-Las-Heras ,
S. Ávila  and
J. Molina
A. Ruiz-Tristan*
Affiliation:
Hospital 12 de Octubre, Villaverde Mental Health Center, Madrid, Spain Hospital 12 de Octubre, Psychiatry, Madrid, Spain
C. Rivera-Clemente
Affiliation:
Hospital 12 de Octubre, Villaverde Mental Health Center, Madrid, Spain
V. Gomez-De-Las-Heras
Affiliation:
Hospital 12 de Octubre, Villaverde Mental Health Center, Madrid, Spain Hospital 12 de Octubre, Psychiatry, Madrid, Spain
S. Ávila
Affiliation:
Complutense University of Madrid, Psychiatry, Madrid, Spain
J. Molina
Affiliation:
Hospital 12 de Octubre, Villaverde Mental Health Center, Madrid, Spain Hospital 12 de Octubre, Center For Biological Research In Mental Health (cibersam), Madrid, Spain Hospital 12 de Octubre, Clinical Management Area Of Psychiatry And Mental Health, Madrid, Spain
*
*Corresponding author.

Abstract

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Introduction

It has been suggested that dysregulation of sex hormones is associated with schizophrenia. However, obesity and metabolic syndrome are very common between schizophrenic patients, and it can also dysregulate sex hormones so they could act as confounders.

Objectives

To determine if estradiol and progesterone are abnormally elevated regardless of obesity or metabolic syndrome in men with SCZ.

Methods

We measured serum levels of progesterone and estradiol in 56 schizophrenic male patients at treatment with a depot antipsychotic. Subsequently, we studied the association or independence of our results with obesity or metabolic syndrome by a Chi Square Test.

Results

66.07% of our patients elevated progesterone levels, 19.64% of our patients elevated estradiol levels, and 16.07% of our patients elevated both, progesterone and estradiol, simultaneously. We found no relationship between increased estradiol and / or progesterone with obesity and / or metabolic syndrome.

Conclusions

Estradiol and progesterone are abnormally elevated regardless of obesity and / or metabolic syndrome in male schizophrenic patients on depot treatment.

Disclosure

No significant relationships.

Keywords

schizophréniaprogesteroneestradiolendocrinology
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S734
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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