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Published online by Cambridge University Press: 15 April 2020
To investigate the effect of Qing huan ling containing serum on proliferation and morphology of human neuroblastoma SH-SY5Y cells.
7 consecutive days gavaged Qing huan ling or Risperidone to rabbit for preparation of Qing huan ling, or risperidone drug-containing rabbit serum. The morphology of SH-SY5Y cells was observed by inverted microscope after 48 hours drug-containing serum treated, and every 24h proliferation of SH-SY5Y cell was tested by the MTT assay.
Qing huan ling containing serum treated 48h SH-SY5Y cell, were close contact between the cells, have pseudopodia, and promote proliferation. Qing huan ling containing serum compared with the blank serum on proliferation of SH-SY5Y cells not statistically significant (P> 0.05), but risperidone containing serum can be a significant increase in the number of SH-SY5Y cells, showing the logarithmic growth trend (P <0.05).
Qing huan ling containing serum can promote on the normal form of the SH-SY5Y cells, on normal proliferation of SH-SY5Y cells without significant intervention, different from the risperidone role.
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