Kleine-Levin syndrome is a rare disorder whose diagnosis is clinical, today there is no clinical test or pathognomonic symptoms feature that facilitates diagnosis. It is necessary to rule out any organic cause etiology to make the diagnosis.

We report a case of a 13 year old patient presented multiple hospitalizations (up to 12) in pediatrics because of behavior and cognitive disturbances: hypersexuality, compulsive eating behavior, hypersomnia, amnesia, and confusion, with the initial diagnosis suspected anti NMDA encephalitis. Throughout its evolution is also studied by psychiatry service. Through this case we explain how finally through the clinical characteristics, the medical test totally normal and the characteristics of the disease patterns (in the form of episodes, absence of symptoms between them …) who our patient is diagnosed with this rare disorder that usually occurs in the second period of life and especially in males.

it is very important to learn about it and be able to identify the characteristics in our work place because in spite of is a rare disorder can have repercussions on a personal (school, family, friends…) environment.