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Elevated osteopontin and IFNy serum levels and increased neutrophil-to-lymphocyte ratio are associated with the severity of symptoms in schizophrenia

Published online by Cambridge University Press:  01 September 2022

M. Kovács ,
T. Tényi ,
R. Kugyelka ,
L. Prenek ,
R. Herold ,
P. Balogh  and
D. Simon
M. Kovács*
Affiliation:
Medical Faculty, University of Pécs, Hungary, Department Of Psychiatry And Psychotherapy, Pécs, Hungary
T. Tényi
Affiliation:
Medical Faculty, University of Pécs, Hungary, Department Of Psychiatry And Psychotherapy, Pécs, Hungary
R. Kugyelka
Affiliation:
Medical Faculty, University of Pécs, Hungary, Department Of Immunology And Biotechnology, Pécs, Hungary
L. Prenek
Affiliation:
Medical Faculty, University of Pécs, Hungary, Department Of Immunology And Biotechnology, Pécs, Hungary
R. Herold
Affiliation:
Medical Faculty, University of Pécs, Hungary, Department Of Psychiatry And Psychotherapy, Pécs, Hungary
P. Balogh
Affiliation:
Medical Faculty, University of Pécs, Hungary, Department Of Immunology And Biotechnology, Pécs, Hungary
D. Simon
Affiliation:
Medical Faculty, University of Pécs, Hungary, Department Of Immunology And Biotechnology, Pécs, Hungary
*
*Corresponding author.

Abstract

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Introduction

Inflammation and immune dysregulation could contribute to the pathogenesis of schizophrenia. Osteopontin (OPN) is a key cytokine-like molecule in cellular immune response and it can directly modulate the cytokine expression and survival of microglia. Furthermore, its mRNA expression is elevated in first episode psychosis. Imbalance of T-helper subtypes could also represent a vulnerability factor for schizophrenia.

Objectives

The aim of this study was to evaluate the relevance of T-helper subtype associated cytokines, OPN and NLR in the assessment of the severity of schizophrenia.

Methods

22 patients with schizophrenia were assessed for the intensity of their symptoms by PANSS and CGI scores. Serum OPN, IFNy, IL-10 and IL-8 concentrations were measured by ELISA kits and NLR was calculated from blood count. Statistical evaluation was performed using Mann-Whitney U test, Student’s t test and Spearman correlation.

Results

We found significant correlation between the level of OPN and PANSS-total, PANSS-general scores. IFNy level and NLR showed significant correlation with PANSS-total, PANSS-positive, PANSS-general and CGI score. Antipsychotic therapy only had significant effects on NLR and OPN levels, both of which were significantly reduced after long-term antipsychotic treatment.

Conclusions

Our results indicate that elevated OPN and IFNy concentrations, and increased NLR are associated with severe symptoms in schizophrenia and suggest the importance of Th1 subtype in patients with high PANSS-positive and PANSS-general score. Antipsychotic treatment had significant effects on the level of OPN and NLR, but not on the level of IFNy. Overall our results strengthen the inflammation hypothesis of schizophrenia.

Disclosure

No significant relationships.

Keywords

osteopontinCytokinesinflammationschizophrénia
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S106
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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