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Elevated C-reactive Protein Levels Associated with Aggressive Behavior in Moroccan Patients with Schizophrenia

Published online by Cambridge University Press:  23 March 2020

A. Kachouchi ,
D.S. Said ,
P.A. Imane ,
P.M. Fatiha  and
P.A. Fatima
D.S. Said
Affiliation:
University hospital Mohammed VI, Department Of Psychiatry, Marrakech, Morocco
P.A. Imane
Affiliation:
University hospital Mohammed VI, Department Of Psychiatry, Marrakech, Morocco
P.M. Fatiha
Affiliation:
University hospital Mohammed VI, Department Of Psychiatry, Marrakech, Morocco
P.A. Fatima
Affiliation:
University hospital Mohammed VI, Department Of Psychiatry, Marrakech, Morocco

Abstract

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Background

Recent studies reported an association between aggression and inflammation. In this study, we examined the association between aggressive behavior and inflammatory markers (serum levels of CRP) in schizophrenia inpatients.

Methods

Adult schizophrenia inpatients (n = 145) were prospectively identified and categorized according to their C-reactive protein measurement at admission as either elevated (CRP > 1 mg/dL; n = 45) or normal (CRP < 1 mg/dL; n = 100). The following indicators of aggression were compared: PANSS excitement component (PANSS-EC), restraints and suicidal behavior during hospitalization.

Results

The results show that patients with elevated CRP levels are more aggressive during hospitalization as detected by statistically significant higher scores of aggressive behavior (PANSS-EC score), and by increased rates of physical restraint during hospitalization. No statistically significant differences in the other clinical features, including suicidal behavior.

Conclusion

Our results are consistent with previous findings linking schizophrenia to activation of the inflammatory response system.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Walk: Schizophrenia and other psychotic disorders - Part 3
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S269
Copyright
Copyright © European Psychiatric Association 2017
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