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The effects of trazodone on sleep disturbances induced by brofaromine

Published online by Cambridge University Press:  16 April 2020

PMJ Haffmans  and
MS Vos
PMJ Haffmans
Affiliation:
Stichting RBC, location Monsterseweg, Monsterseweg 83, 2553the Hague, the Netherlands
MS Vos
Affiliation:
Stichting RBC, location Monsterseweg, Monsterseweg 83, 2553the Hague, the Netherlands
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Summary

The effects of trazodone on subjective and objective sleep parameters were compared to those of placebo in a double-blind design in seven patients who developed insomnia during treatment with the selective and reversible MAO-A inhibitor, brofaromine. Trazodone significantly increased deep sleep and altered the architecture of sleep in these patients. Subjectively, patients reported a better and deeper sleep. No negative interactions between brofaromine and trazodone were observed and side-effects were minimal. A low dose of trazodone may be a safe and effective agent in the treatment of MAO-I induced insomnia.

Keywords

depressioninsomniaMAO-A inhibitortrazodone
Type
Short Communications
Information
European Psychiatry , Volume 14 , Issue 3 , June 1999 , pp. 167 - 171
Copyright
Copyright © European Psychiatric Association 1999

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References

Kurz, NM, Robinson, DSMonoamine oxidase inhibitors In: Georgotas, A, Cranco, R eds. Depression and mania: a comprehensive textbook 1988 New York: Elsevier 358–371.Google Scholar
Steiger, A, Holsboer, F, Gerken, AResults of an open clinical trial of brofaromine (CGP II 305 A), a competitive, selective, and short acting inhibitor of MAO-A in major endogenous depression. Pharmacopsychiatry 1987 ; 20 : 262–269.CrossRefGoogle Scholar
Nolen, WA, Haffmans, PMJ, Bouvy, PF, Duivenvoorden, HJMonoamine oxidase inhibitors in resistant major depression. J Affect Disord 1993 ; 28 : 189–197.CrossRefGoogle ScholarPubMed
Hoencamp, E, Haffmans, PMJBrofaromine vs maprotiline plus lithium in treatment resistant depressed out patients. Psychiatry Res 1991 ; 36 : 333–335.CrossRefGoogle Scholar
Hamilton, MA rating scale for depression. Acta Psychiatr Scand 1989 ; 73 Suppl 326 : 1–37.Google Scholar
Haffmans, PMJ, Knegtering, RThe selective reversible monoamine oxidase-A inhibitor brofaromine and sleep. J Clin Psychopharmacol 1993 ; 13 : 291–292.CrossRefGoogle Scholar
van Bemmel, AL, van Diest, R, Mevius, GJThe effects of REM-sleep suppression on non-REM sleep intensity in depressed patients treated with trazodone. Biol Psychiatry 1991 ; 29 : 620620.Google Scholar
Ware, JC, Pittard, JTIncreased deep sleep after trazodone use: a double blind placebo controlled study in healthy young adults. J Clin Psychiatry 1990 ; 51 : 18–22.Google ScholarPubMed
Wheatly, DTrazodone: alternative dose regimens and sleep. Pharmatherapeutica 1984 ; 3 : 607–612.Google Scholar
Scharf, MB, Sachais, BASleep laboratory evaluation of the effects and efficacy of trazodone in depressed insomniac patients. J Clin Psychiatry 1990 ; 51 : 13–17.Google ScholarPubMed
Mouret, J, Lemoine, P, Minuit, MPEffects of trazodone on the sleep of depressed subjects – a polygraphic study. Psychopharmacology 1988 ; 95 : 37–43.CrossRefGoogle ScholarPubMed
Maj, J, Palider, W, Rawlow, ATrazodone, a central serotonin antagonist and agonist. J Neural Trans 1979 ; 44 : 237–248.CrossRefGoogle ScholarPubMed
Zimmer, B, Daly, F, Benjamin, LMore on combination antidepressant therapy. Arch Gen Psychiatry 1984 ; 41 : 527–528.Google ScholarPubMed
Nierenberg, AA, Keck, PEManagement of monoamine oxidase inhibitor-associated insomnia with trazodone. J Clin Psychopharmacol 1989 ; 9 : 42–45.CrossRefGoogle ScholarPubMed
Jacobson, FMLow-dose trazodone as a hypnotic in patients treated with MAOIs and other psychotropics: a pilot study. J Clin Psychiatry 1990 ; 51 : 298–302.Google Scholar
Fawcett, J, Epstein, P, Fiester, SJSymptoms, signs, side-effects checklist. Psychopharmacol Bull 1987 ; 23 : 322–323.Google Scholar
Mulder, W, Wijnberg, JR, Hollander, JJMeasurements of subjective sleep quality. 5th European sleep congress 1980 Amsterdam: ESRGoogle Scholar
Rechtschaffen, A, Kales, AA manual of standardized terminology techniques and scoring system for sleep stages of human subjects US Department of Health, Education of Welfare 1980 Bethesda: Neurological Information NetworkGoogle Scholar
Waldmeier, PC, Baumann, PA, Delini-Stula, ACharacterization of a new, short acting and specific inhibitor of type A monoamine oxidase. Mod Probl Pharmacopsychiatr 1983 ; 19 : 31–52.CrossRefGoogle ScholarPubMed
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