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Effects of tianeptine on attention, memory and psychomotor performances using neuropsychological methods in young healthy volunteers

Published online by Cambridge University Press:  16 April 2020

MF Poirier ,
A Galinowski ,
I Amado-Boccara ,
B Delalleau ,
N Gougoulis  and
H Lôo
MF Poirier
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Hôpital Sainte-Anne, 1, rue Cabanis, 75674Paris Cedex 14 and Paris V Cochin University
A Galinowski
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Hôpital Sainte-Anne, 1, rue Cabanis, 75674Paris Cedex 14 and Paris V Cochin University
I Amado-Boccara
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Hôpital Sainte-Anne, 1, rue Cabanis, 75674Paris Cedex 14 and Paris V Cochin University
B Delalleau
Affiliation:
IRIS, 6, Place des Pléiades, 92415Courbevoie Cedex
N Gougoulis
Affiliation:
SM 22, Hôpital Sainte-Anne, 1, rue Cabanis, 75674Paris Cedex 14, France
H Lôo
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Hôpital Sainte-Anne, 1, rue Cabanis, 75674Paris Cedex 14 and Paris V Cochin University
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Summary

A study was performed in young healthy volunteers in order to test the possible action of tianeptine, a new antidepressant drug, on cognitive performances. Attention tests, memory tests, a non-verbal inductive reasoning test and a sleep questionnaire were used in this double-blind placebo-controlled crossover study. The two one-week drug administration periods were separated by a one-week wash-out period. The methodology permitted us to evaluate the learning effect during the familiarization with the tests and to clear the results of the study from this parameter which could possibly distort analysis. For this large range of tests, the results showed that tianeptine did not affect the level of functioning of the volunteers after their familiarization with the tests. These results are in contrast with those obtained by different authors with classical tricyclic antidepressants.

Keywords

tianeptineantidepressantsmemoryattentionsleep
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S2: Neuroendocrinological aspects of depression 28 June 1992, Nice, France , 1993 , pp. 95s - 102s
Copyright
Copyright © Elsevier, Paris 1993

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