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The effects of prenatal morphine exposure on pain response
Published online by Cambridge University Press: 16 April 2020
Abstract
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Background
Drug abuse during pregnancy is a growing problem in all developed countries of the world. Maternal drug abuse affects the developing system and its long-term effects can persist till adulthood so it can decreases the rate of their maturation. Since endogenous opioid induced analgesia, and morphine can interact with it, Thus the present study was designed to determine whether the exposure to the morphine during gestation permanently alter pain response.
Objective
To determine the effects of prenatal morphine exposure on pain response
Materials and methods
12 Pregnant rats were divided to morphine and control groups.
Morphine was administrated (S.C) to female rats twice a day (08 h and 20 h) on gestational days 11–18, (5 mg/kg morphine for 3 days and 10 mg/kg for 5 days). Analgesic response of pups (P90, n = 6) were tested by formaline test.
Finding
The results of our experiment demonstrated that prenatal morphine exposure rats exhibited significantly lower pain thersholds.
Conclusion
Prenatal morphine exposure impair pain sensitivity
- Type
- P02-393
- Information
- European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 989
- Copyright
- Copyright © European Psychiatric Association 2011
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