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Effects of Immunomodulatory Peptide Y On Cognitive Functions in Animal Models

Published online by Cambridge University Press:  15 April 2020

M. Lemieszewska
Affiliation:
Division of Consultation Psychiatry and Neuroscience Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland
B. Stanczykiewicz
Affiliation:
Division of Consultation Psychiatry and Neuroscience Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland
M. Jakubik-Witkowska
Affiliation:
Division of Consultation Psychiatry and Neuroscience Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland
A. Zambrowicz
Affiliation:
Department of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
A. Polanowski
Affiliation:
Department of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
J. Rymaszewska
Affiliation:
Division of Consultation Psychiatry and Neuroscience Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland

Abstract

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Despite the great intensity of studies to explain mechanisms of the Alzheimer’s disease, there’s still lack of effective prevention and treatment. As many specimens had been unadmitted because of their adverse side effects, thus recent attempts to follow natural biological protective mechanisms might open a range of possibilities in developing novel drugs to slow down processes of dementia and cognitive impairment. Promising results were achieved in patients treated with herbal agents, such as Gingko biloba extract, as well as animal derived preparations, i.a. PRP/Colostrinine (proline rich polipeptyde) complex isolated from ovine and bovine colostrum with confirmed immunomodulating properties and pro-cognitive action on memory and learning functions.

The contribution of egg yolk (vitellus) ingredients to chicks development appeared similar to mammalian colostrum role in growth and immunity of newborns. Recently discovered polipeptyde complex associated with IgY, named Yolkine,has been put to the series of experiments in order to determine the effects of egg yolk preparations on cognitive functions in young and old rats as a model of cognitive decline and process of brain aging.

To estimate Yolkine efficiency, different doses and routes of administration were applied, along with wide range of aging-sensitive behavioral tests, i.a. novel object recognition task and Morris water maze. The authors will present the results of the ongoing study and key findings.

Type
Article: 1557
Copyright
Copyright © European Psychiatric Association 2015
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