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Effects of Chinese Herb Danshen-Dahuang on Hippocampal Gene Expression of APP and PS1 in Rats with Alzheimer Disease

Published online by Cambridge University Press:  16 April 2020

B. Han ,
R. Tang ,
D. Han ,
F. Wang ,
S. Zhao  and
M. Xu
B. Han
Affiliation:
Department of Psychiatry, The First Hospital, Shanxi Medical University, Taiyuan City, China Department of Neurology, Tongji Hospiatal, Tongji Medical College, Huazhong Science and Technology University, Wuhan, China
R. Tang
Affiliation:
Department of Neurology, Tongji Hospiatal, Tongji Medical College, Huazhong Science and Technology University, Wuhan, China
D. Han
Affiliation:
Institute of Hepatology, Shanxi Medical University, Taiyuan City, China
F. Wang
Affiliation:
Institute of Hepatology, Shanxi Medical University, Taiyuan City, China
S. Zhao
Affiliation:
Department of Psychiatry, The First Hospital, Shanxi Medical University, Taiyuan City, China
M. Xu
Affiliation:
Department of Psychiatry, The First Hospital, Shanxi Medical University, Taiyuan City, China

Abstract

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Aims:

To investigate the effect of Chinese herb Danshen-Dahuang on learning and memory ability in rats with Alzheimer disease (AD) induced by D-galactose and AlCl3 and its possible mechanisms.

Methods:

The AD model was produced by injecting D-galactose and AlCl3 intraperitoneally for 90 days. Since the 20th day of D-galactose and AlCl3 intraperitoneal injection, the rats in Danshen-Dahuang group had been treated with Danshen-Dahuang extraction by intragastric administration for 70 days. Subsequently,learning and memory ability of the mice was evaluated by Morris water maze and hippocampal gene expression of APP, PS1 was tested by reverse transcription polymerase chain reaction (RT-PCR).

Results:

Rats intragastric administration with Danshen-Dahuang, mice had shorter latency (P< 0.05) and less error times (P< 0.05) in water maze test compared with those in AD model group. At the same time, Danshen-Dahuang down regulated the expression of APP, PS1 mRNA (P< 0.05) in hippocampus.

Conclusions:

Danshen-Dahuang improves the learning and memory ability of AD rats, its mechanism may be related to the downregulated expression of APP, PS1 mRNA.

Type
P01-94
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E482
Copyright
Copyright © European Psychiatric Association 2009
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