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The effect psychobiotics on anxiety symptoms

Published online by Cambridge University Press:  19 July 2023

Y. Denysov ,
G. Putyatin ,
S. Moroz  and
V. Semenikhina
Y. Denysov*
Affiliation:
Psychiatry, psychotherapy, addictology and medical psychology, Donetsk national medical university, Kropyvnitskyi
G. Putyatin
Affiliation:
Psychiatry, psychotherapy, addictology and medical psychology, Donetsk national medical university, Kropyvnitskyi
S. Moroz
Affiliation:
Psychiatry, Municipal Enterprise “Dnipro Multiprofile Clinical Hospital for the Provision of Psychiatric Care of Dnipropetrovsk Regional Council, Dnipro, Ukraine
V. Semenikhina
Affiliation:
Psychiatry, Municipal Enterprise “Dnipro Multiprofile Clinical Hospital for the Provision of Psychiatric Care of Dnipropetrovsk Regional Council, Dnipro, Ukraine
*
*Corresponding author.

Abstract

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Introduction

Psychobiotics are a group of probiotics that affect the central nervous system related functions and behaviors mediated by the gut-brain-axis via immune, humoral, neural, and metabolic pathways to improve not only the gastrointestinal function but also the antidepressant and anxiolytic capacity.

Objectives

An assessment of psychobiotic and anti-anxiety effects a probiotic supplement containing Lactobacillus Plantarum CECT7485 and Lactobacillus Brevis CECT7480 (PLANTARUM) in patients with anxiety undergoing treatment with selective serotonin reuptake inhibitors (SSRI) antidepressants.

Methods

Sixty patients with mixed anxiety and depressive disorder (according to ICD-10 diagnostic criteria F41.2) were included in an 8-week open label study. Thirty participants received either SSRI antidepressants with PLANTARUM at a dose of 1.0 × 109 CFU once per day and thirty patients received SSRI antidepressants only. The severity of anxiety symptoms was assessed using Hamilton Anxiety Rating Scale (HAM-A) and General Anxiety Disorder Scale (GAD-7).

Results

After 8 weeks intervention, a significant reduction of HAM-A total score (from 37,8±5,3 to 23,6±4,4) was detected in patients with anxiety who prescribed SSRI antidepressants and PLANTARUM (p˂0,05), compared with participants who didn’t receive probiotics (p>0,05). Also, a significant reduction of GAD-7 total score (from 21,7±3,3 to 12,5±2,4) was detected in patients with anxiety symptoms who received SSRI antidepressants and PLANTARUM (p˂0,01), compared with patients who didn’t intake probiotics (p>0,05).

Conclusions

The present data illustrated that probiotic supplement PLANTARUM is a feasible for adjunctive to SSRI antidepressants intervention for anxiety treatment.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S453 - S454
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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