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Effect of clozapine and olanzapine on cortical excitability in schizophrenia

Published online by Cambridge University Press:  16 April 2020

C. Ben Amor ,
A. Galinowski ,
B. Gueguen ,
M.C. Bourdel ,
R. Waismann ,
B. Granger ,
Q. Debray ,
J.P. Olie  and
M.O. Krebs
C. Ben Amor
Affiliation:
INSERM U796 PARIS V, SHU Hopital Sainte-Anne, Paris, France
A. Galinowski
Affiliation:
INSERM U796 PARIS V, SHU Hopital Sainte-Anne, Paris, France
B. Gueguen
Affiliation:
Service de Neurophysiologie Clinique, Hopital Sainte-Anne, Paris, France
M.C. Bourdel
Affiliation:
INSERM U796 PARIS V, SHU Hopital Sainte-Anne, Paris, France
R. Waismann
Affiliation:
INSERM U796 PARIS V, SHU Hopital Sainte-Anne, Paris, France
B. Granger
Affiliation:
Service de Psychiatrie Universitaire. Hopital Corentin Celton, Paris, France
Q. Debray
Affiliation:
Service de Psychiatrie Universitaire. Hopital Corentin Celton, Paris, France
J.P. Olie
Affiliation:
INSERM U796 PARIS V, SHU Hopital Sainte-Anne, Paris, France
M.O. Krebs
Affiliation:
INSERM U796 PARIS V, SHU Hopital Sainte-Anne, Paris, France

Abstract

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Cortical excitability is modified in schizophrenia [1] but the effect of antipsychotic drugs has been disputed. In particular, patients receiving olanzapine and risperidone showed less cortical disinhibition compared to untreated schizophrenic subjects [2]. However, despite the observed increase, the Resting Motor Threshold (RMT) remained inferior to the RMT in normal controls, and the Transcallosal Conduction Time (TCT) did not change.

There is no comparative study of the effect of clozapine, an effective antipsychotic with proconvulsant properties.

We studied cortical excitability by transmagnetic stimulation in stabilized schizophrenic patients treated by clozapine (n=10), olanzapine (n=10) compared to healthy volunteers (n=10).

The aim of this study was to extend previous research into inhibitory deficits in schizophrenia and to compare the effect of clozapine and olanzapine on neurophysiological parameters such as RMT, Intracortical Inhibition (ICI), Intracortical Facilitation (ICF), Cortical Silence Period (CSP) and Transcallosal Inhibition (TI).

In clozapine treated patients, the RMT and ICI were significantly lower (p<0.05) compared to olanzapine treated and healthy subjects. TCT was longer in schizophrenic patients without difference in treatment subgroups.

Conclusion

The trend toward normalization of RMT and ICI with antipsychotic treatment seems to be independent of the magnitude of therapeutic effect.

Type
Poster Session 1: Schizophrenia and Other Psychosis
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S103
Copyright
Copyright © European Psychiatric Association 2007

References

Alvaro, Pascual-LeoneBiol Psychiatry 2002; 25(52): 2431Google Scholar
Paul B., FitzgeraldPsychopharmacology 2002; 162: 74–81Google Scholar
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