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ECT rekindles pharmacological response in schizophrenia

Published online by Cambridge University Press:  16 April 2020

H. Hustig  and
R. Onilov
H. Hustig
Affiliation:
Central Northern Adelaide Health ServiceRoyal Adelaide Hospital, Adelaide, Australia
R. Onilov*
Affiliation:
Central Northern Adelaide Health ServiceRoyal Adelaide Hospital, Adelaide, Australia
*
*Corresponding author. 5/21 Giles St, Toorak Gardens, SA 5065, Australia. Tel.: +61 8 83311324, +61 439578617 (mob). E-mail address:[email protected] (R. Onilov).
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Abstract

Objective

The aim of our naturalistic-observational study was to determine the efficacy and utility of electroconvulsive therapy (ECT) in clinical population of individuals with schizophrenia where pharmacological response was suboptimal.

Methods

The cohort comprised 27 patients suffering from schizophrenia with refractoriness to antipsychotic agents and with severe, disabling symptoms. They only interventional assessing tool was clinical global impression (CGI-S) performed at the baseline and at the end of the treatment.

Results

The administration of ECT resulted in overall clinical improvement reflected in CGI scales and descriptions in clinical notes. On 12 months follow-up period, 10 patients (37.1%) maintained improvement and were able to continue with pharmacological therapy only, suggesting its rekindling effect, especially with Clozapine. Conversely, 17 patients (62.9%) deteriorated and required an additional course of ECT to maintain improvement. In some cases, maintenance ECT treatment was required. The group who engaged in self-harming behaviour at baseline demonstrated they were more likely to relapse into psychosis at the end of the first course of ECT, their self-harming behaviour abated, especially when maintenance ECT was undertaken.

Conclusions

Although limited by lack of control group, small sample size, heterogeneous symptom profiles and various concurrent neuroleptic agents, the ECT proved as valuable and safe augmentative procedure when unsatisfactory response to pharmacological interventions had been demonstrated prior to interventions. This effect was evident despite the chronicity of the illness.

Keywords

ECTSchizophreniaPharmacological responsiveness
Type
Original article
Information
European Psychiatry , Volume 24 , Issue 8 , December 2009 , pp. 521 - 525
Copyright
Copyright © Elsevier Masson SAS 2009

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Footnotes

1

Rehabilitation Services, Glenside Campus, CNAHS, Adelaide, Australia.

2

Emergency Department, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia.

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