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A double-blind randomised comparative trial of amisulpride versus olanzapine for 2 months in the treatment of subjects with schizophrenia and comorbid depression

Published online by Cambridge University Press:  16 April 2020

J.-M. Vanelle  and
S. Douki
J.-M. Vanelle*
Affiliation:
Service de psychiatrie, hôpital Saint-Jacques, 85, rue Saint-Jacques, 44200Nantes, France
S. Douki
Affiliation:
Hôpital Razi, La Manouba, Tunisia
*
*Corresponding author. E-mail address: [email protected] (J.-M. Vanelle).
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Abstract

Purpose

To compare the efficacy and safety of amisulpride and olanzapine in subjects with schizophrenia and comorbid depression in a randomised double-blind trial.

Patients

Eighty-five adult patients fulfilling DSM-IV criteria for schizophrenia and presenting a depressive episode were randomised to amisulpride (200–600 mg/day) or olanzapine (5–15 mg/day) for 8 weeks. Primary efficacy variables were change in Calgary Depression Scale (CDS) score and Clinical Global Impression (CGI) of Change. Safety was monitored by adverse event reporting and determination of extrapyramidal function and metabolic variables.

Results

The mean change from baseline of CDS score was –6.84 in the amisulpride group and –7.36 in the olanzapine group. 65.9% and 61.5% of subjects, respectively, were considered “much” or “very much” improved. No significant inter-group difference in effect size was observed. The frequency of adverse events was low and emergence of extrapyramidal symptoms was not seen. Four patients in the olanzapine group developed abnormal triglyceride levels. Mean weight gain was 1.45 and 0.5 kg, respectively, in the olanzapine and amisulpride groups.

Conclusion

Amisulpride and olanzapine are effective in patients with schizophrenia and comorbid depression. Tolerance of both drugs was acceptable, although use of olanzapine was associated with a trend toward greater metabolic side-effects [19].

Keywords

AmisulprideOlanzapineSchizophreniaDepressionRandomised clinical trial
Type
Original article
Information
European Psychiatry , Volume 21 , Issue 8 , December 2006 , pp. 523 - 530
Copyright
Copyright © Elsevier Masson SAS 2006

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