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Distinct alternations of brain functional network dynamics in obsessive-compulsive disorder and schizophrenia

Published online by Cambridge University Press:  13 August 2021

L. Luo*
Affiliation:
Huaxi Mr Research Centre (hmrrc), Department Of Radiology, West China Hospital of Sichuan University, Sichuan, China
Y. Yang
Affiliation:
Department Of Psychiatry, West China Hospital of Sichuan University, Chengdu, China
Q. Gong
Affiliation:
Huaxi Mr Research Centre (hmrrc), Department Of Radiology, West China Hospital of Sichuan University, Chengdu, China
F. Li
Affiliation:
Huaxi Mr Research Centre (hmrrc), Department Of Radiology, West China Hospital of Sichuan University, Chengdu, China
*
*Corresponding author.

Abstract

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Introduction

Obsessive-compulsive disorder (OCD) and schizophrenia (SZ) are both severe psychiatric disorders. Though these two disorders have distinct typical symptoms, there are partial polygenic overlap and comorbidity between the two disorders. However, few studies have explored the shared and disorder-specific brain function underlying the neural pathophysiology of the two disorders, especially in the aspect of dynamics.

Objectives

To explore the abnormal characteristics of the dynamic functional connectivity (dFC) in OCD and SZ as well as the association between dFC metrics and symptom severity.

Methods

The resting state functional magnetic resonance imaging data of 31 patients with OCD, 49 patients with SZ, and 45 healthy controls were analyzed using independent component analysis to obtain independent components (ICs) and assigned them into eight brain networks (Figure 1), then used the sliding-window approach to generate dFC matrices. Using k-means clustering, we obtained three reoccurring dFC states (Figure 2), and state transition metrics were obtained

Results

In a sparsely connected state (state 1), SZ showed both increased fractional time and mean dwell time than controls (P=0.047 and P=0.033) and OCD (P=0.001 and P=0.003). In a state characterized by negative FC between networks (state 2), OCD showed both increased fractional time and mean dwell time than controls (P=0.032 and P=0.013) and SZ (P=0.005 and P=0.003). Moreover, the fractional time of state 2 was positively correlated with anxiety scores in OCD (r=0.535, P=0.021, FDR corrected) (Figure 3).

Conclusions

OCD and SZ patients showed distinct alternations of brain functional dynamics.

Disclosure

No significant relationships.

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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