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Discriminant cognitive factors in responder and non-responder patients with schizophrenia

Published online by Cambridge University Press:  16 April 2020

E. Stip ,
I. Lussier ,
E. Ngan ,
A. Mendrek  and
P. Liddle
E. Stip
Affiliation:
Centre de recherche Fernand Seguin, Hôpital L.H. Lafontaine, Université de Montréal, 7331 rue Hochelaga, Montreal HIN 3V2 Québec Department of Psychiatry, University of British Columbia, Vancouver, Canada
I. Lussier
Affiliation:
Centre de recherche Fernand Seguin, Hôpital L.H. Lafontaine, Université de Montréal, 7331 rue Hochelaga, Montreal HIN 3V2 Québec
E. Ngan
Affiliation:
Department of Psychiatry, University of British Columbia, Vancouver, Canada
A. Mendrek
Affiliation:
Department of Psychiatry, University of British Columbia, Vancouver, Canada
P. Liddle
Affiliation:
Department of Psychiatry, University of British Columbia, Vancouver, Canada
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Summary

To identify which improvements in cognitive function are associated with symptom resolution in schizophrenic patients treated with atypical antipsychotics. Design: a prospective open trial with atypical neuroleptics (risperidone, clozapine, quetiapine). Setting: Inpatient and outpatient units, Institute of Psychiatry. Patients: Thirty-nine patients with schizophrenia according to DSM-IV criteria were included. Clinical and cognitive assessment were done at baseline (T0) and again after six months of treatment (T2). Twenty-five patients completed the trial. Interventions: New-generation antipsychotics during six months. Patients were considered as responders if their PANSS score decreased at least 20% (n = 15) and non-responders if it did not (n = 10). Outcome measures: a computerized cognitive assessment comprised tests of short-term-memory (digit span), explicit long-term memory (word pair learning), divided attention, selective attention and verbal fluency (orthographic and semantic). Clinical assessment included PANSS and ESRS. Results: A discriminant function analysis was performed to determine which changes in cognitive performance predicted symptomatic response status. Semantic fluency and orthographic fluency were significant predictors. Together they correctly predicted responder status in 88% of cases. Memory was not a significant predictor of symptomatic response. Conclusion: Verbal fluency discriminated the responder from the non-responder group during a pharmacological treatment.

Keywords

antipsychoticclozapinecognitionquetiapineresponderrisperidoneschizophreniaverbal fluency
Type
Original article
Information
European Psychiatry , Volume 14 , Issue 8 , December 1999 , pp. 442 - 450
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 1999

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