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Accepted manuscript

Development and Predictors of Bipolar Disorder in Children and Adolescents with Depressive Disorders A Systematic Review, Meta-analysis and Meta-regression

Published online by Cambridge University Press:  08 January 2025

Gonzalo Salazar de Pablo Open the ORCID record for Gonzalo Salazar de Pablo [Opens in a new window] ,
Violeta Perez-Rodriguez Open the ORCID record for Violeta Perez-Rodriguez [Opens in a new window] ,
Javier de Otazu Olivares Open the ORCID record for Javier de Otazu Olivares [Opens in a new window] ,
Javier Camacho-Rubio Open the ORCID record for Javier Camacho-Rubio [Opens in a new window] ,
Aditya Sharma Open the ORCID record for Aditya Sharma [Opens in a new window] ,
Ana Catalán Open the ORCID record for Ana Catalán [Opens in a new window] ,
Josefien Breedvelt Open the ORCID record for Josefien Breedvelt [Opens in a new window] ,
Claudia Aymerich Open the ORCID record for Claudia Aymerich [Opens in a new window] ,
Mihai Pop Open the ORCID record for Mihai Pop [Opens in a new window]  and
Carmen Moreno Open the ORCID record for Carmen Moreno [Opens in a new window]
...Show all authors
Gonzalo Salazar de Pablo*
Affiliation:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London UK Child and Adolescent Mental Health Services, South London and Maudsley NHS Foundation Trust, London, UK Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain
Violeta Perez-Rodriguez
Affiliation:
Child and Adolescent Mental Health Services, South London and Maudsley NHS Foundation Trust, London, UK
Javier de Otazu Olivares
Affiliation:
Universidad Nacional Pedro Henriquez Ureña, Santo Domingo, Dominican Republic
Javier Camacho-Rubio
Affiliation:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain
Aditya Sharma
Affiliation:
Academic Psychiatry, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK National Specialist Adolescent Mood Disorders Service (NSAMS), Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK
Ana Catalán
Affiliation:
Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London UK Psychiatry Department. Biocruces Bizkaia Health Research Institute, OSI Bilbao-Basurto. Facultad de Medicina y Odontología, University of the Basque Country UPV/EHU. Centro de Investigación en Red de Salud Mental. (CIBERSAM), Instituto de Salud Carlos III. Barakaldo. Bizkaia. Spain
Josefien Breedvelt
Affiliation:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London UK
Claudia Aymerich
Affiliation:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London UK Psychiatry Department. Biocruces Bizkaia Health Research Institute, OSI Bilbao-Basurto. Facultad de Medicina y Odontología, University of the Basque Country UPV/EHU. Centro de Investigación en Red de Salud Mental. (CIBERSAM), Instituto de Salud Carlos III. Barakaldo. Bizkaia. Spain
Mihai Pop
Affiliation:
East London NHS Foundation Trust, London, UK
Carmen Moreno
Affiliation:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain
Ian Kelleher
Affiliation:
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom School of Medicine, University College Dublin, Dublin, Ireland University of Oulu, Faculty of Medicine, Oulu, Finland St John of God Hospitaller Services Group, Stillorgan, Dublin, Ireland
Jane Anderson
Affiliation:
Child and Adolescent Mental Health Services, South London and Maudsley NHS Foundation Trust, London, UK
Paolo Fusar-Poli
Affiliation:
Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London UK Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy OASIS Service, South London and Maudsley NHS Foundation Trust, London, UK National Institute for Health Research, Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK
Christoph U Correll
Affiliation:
Department of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York, USA Department of Psychiatry and Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA Center for Psychiatric Neuroscience, The Feinstein Institutes for Medical Research, Manhasset, New York, USA Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany
Allan H. Young
Affiliation:
National Institute for Health Research, Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK Centre for Affective Disorders, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Beckenham, United Kingdom.
*
Corresponding author:*Correspondence to: Dr Gonzalo Salazar de Pablo. Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience (IoPPN) King’s College London. 16 De Crespigny Park, London SE5 8AB Tel: 0207 848 0002. Email: gonzalo,[email protected]

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Keywords

Bipolar Disorderdepressive disordersmeta-analysischildrenadolescentsprevention
Type
Review/Meta-analysis
Information
European Psychiatry , Accepted manuscript , pp. 1 - 37
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of the European Psychiatric Association
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