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Depression and monocyte dysfunction: a follow-up study

Published online by Cambridge University Press:  16 April 2020

S Cervera-Enguix  and
A Rodriguez-Rosado
S Cervera-Enguix
Affiliation:
Faculty of Medicine, Psychiatry and Medical Psychology Department, Universitary Hospital of the University of Navarra; Apartado 192, 31080Pamplona Navarra, Spain
A Rodriguez-Rosado
Affiliation:
Faculty of Medicine, Psychiatry and Medical Psychology Department, Universitary Hospital of the University of Navarra; Apartado 192, 31080Pamplona Navarra, Spain
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Summary

Several studies have reported immune cellular and humoral dysfunction during depression. We specifically focused on the study of the monocyte as it has a key role in the activation of the immune response. To examine the association between severity of depressive symptoms and values of monocyte parameters (HLA-DR, CD35, phagocytic activity and vimentin filaments), we used a longitudinal design and assessed monocyte markers at intake and at follow-up 12 weeks after discharge from the hospital in 49 depressed patients. Seventy percent of patients showed pretreatment a marked monocyte dysfunction (82.5% had at least one parameter altered). After treatment, alterations in immunological variables were significantly associated (P < 0.05) with depression scores higher than 15. The findings indicate that the monocyte dysfunction is temporally associated with the state of depression. Before and after treatment the immunoreactive vimentin filaments significantly increased (P < 0.01) after incubation of monocytes with naloxone, suggesting that an increased opioid activity might account for the monocyte dysfunction.

Keywords

depressionmonocyte dysfunction
Type
Original article
Information
European Psychiatry , Volume 9 , Issue 6 , 1994 , pp. 293 - 298
Copyright
Copyright © European Psychiatric Association 1994

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References

Auger, MJRoss, JAThe biology of the macrophageIn: Lewis, CEMcCice, J eds. The macrophage New York: Oxford University Press, 1992;3-74Google Scholar
Bianco, CPatrick, RNussenzwig, VA population of lymphocytes bearing membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization J Exp Med 1970;132: 702-20CrossRefGoogle ScholarPubMed
Blalock, JESmith, EMHuman leukocyte interferon: structural and biological relatedness to adrenocorticotrophic hormones and endorphins Proc Natl Acad Sci USA 1980;77: 5975-8CrossRefGoogle Scholar
Blalock, JEHarp, CInterferon and adrenocorticotropic hormone induction of steroidogenesis, melanogenesis and antiviral activity Arch Virol 1981;67: 45-9CrossRefGoogle ScholarPubMed
Bormann, BJHuang, CKLan, GFJaffe, EAThrombin-induced vimentin phosphorylation in cultured human umbilical vein endothelial cells J Biol Chem 1986,261:10471-4Google ScholarPubMed
Boyum, AIsolation of human blood monocytes with Nycodenz, a new non-ionic iodinated gradient medium Scand J Immunol 1983; 17: 429-36CrossRefGoogle ScholarPubMed
Browning, ETSanders, MMVimentin: a phosphoprotein under hormonal regulation J Cell Biol 1981;90: 803-8CrossRefGoogle ScholarPubMed
Catala, J Benzodiazepine effects on the mononuclear-macrophage system. Doctoral Thesis, University of Navarra, Pamplona, 1992Google Scholar
Cervcra, SSarrais, ERamos, F Depression, Immune system and Neuroendocrine Tests. Spanish Biological Psychiatry Association, 13th National Meeting. Cordoba, Spain, 1991)Google Scholar
Chang, KGOpioid peptides have actions on the immune system Trends Neurosci 1984;7: 234-5CrossRefGoogle Scholar
Erochner, SCThe role of the postsynaptic cyloskeleton in AchR organization Trends Neurosci 1986;9: 37-8Google Scholar
Geiger, BIntermediate filaments. Looking for a function Nature 1987;329: 392-3CrossRefGoogle ScholarPubMed
Giorgi, JVLymphocyte subset measurements: significance in clinical medicineIn: Rose, NRFriedman, HFahey, JL eds. Manual of Clinical Immunology 3rd edn. Washington, DC: American Society for Microbiology, 1986;236-46Google Scholar
Hamilton, MA rating scale for depression J Neurol Neurosurg Psychiatr 1960;23: 56–61CrossRefGoogle Scholar
Irwin, MLacher, UCaldwell, CDepression and reduced natural killer cytotoxicity: a longitudinal study of depressed patients and control subjects Psychol Med 1992;22: 1045-50CrossRefGoogle ScholarPubMed
Krishnan, REllinwood, EHLaszlo, JHood, LRitchie, JEffect of gamma interferon on the hypothalamic-piluitary-adrenal system Biol Psychiatry 1987;22: 1163-6CrossRefGoogle ScholarPubMed
Lazarides, EIntermediate filaments as mechanical integrators of cellular space Nature 1980;283: 249-56CrossRefGoogle ScholarPubMed
Lopker, AAbood, LGHoss, WLionetti, FGStereoselective muscarinic acetylcholine and opiate receptors in human phagocytic leukocytes Biochem Pharmacol 1980;29: 1361-5CrossRefGoogle ScholarPubMed
Maes, MBosmans, ESuy, EMinner, BRaus, JA further exploration of the relationship between immune parameters and the HPA-axis activity in depressed patients Psychol Med 1991;21: 313-20CrossRefGoogle ScholarPubMed
Maes, MLambrechts, JBosmans, Eet al. Evidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining Psychol Med 1992;22: 45–53CrossRefGoogle ScholarPubMed
Pert, CBRuff, MRWeber, RTHerkenham, MNeuropeptides and their receptors: a psychosomatic network J Immunol 1985;135: 820-6Google ScholarPubMed
Plotnikoff, NPMiller, GCEnkephalins as immunomodulators Int J Immunopharmacol 1983;5: 437-41CrossRefGoogle ScholarPubMed
Plotnikoff, NPMurgo, AJMiller, GCCorder, CNFaith, REEnkephalins: immunomodulators Fed Proc 1985;44: 118-22Google ScholarPubMed
Plotnikoff, NPFaith, REMurgo, AJGood, RAIntroduction: the ying-yang hypothesis of immunomodulation In: Plotnikoff, NPFaith, REMurgo, AJGood, RA eds. Enkephalins and Endorphins: Stress and the Immune System New York: Plenum Press, 1986; 1–2Google Scholar
Prieto, JSubira, MLCastilla, ASerrano, MNaloxone-reversible monocyte dysfunction in patients with chronic fatigue syndrome Scand J Immunol 1989;30: 13–20CrossRefGoogle ScholarPubMed
Prieto, JCamps-Bansell, JCastilla, AOpioid-mediated monocyte dysfunction in the chronic fatigue syndromeIn: Bonnie Cameron, ed. The Clinical and Scientific Basis of Mialgic Encephalomyelitis Chronic Fatigue Syndrome Ottawa, Ontario (Canada) and Ogsdenburg, New York: Nightingale Research Foundation, 1992;575-84Google Scholar
Recalde, HRA simple method of obtaining monocytes in suspension J Immunol Methods 1984;69:71-7CrossRefGoogle ScholarPubMed
Ruff, MRPert, CBHuman monocyte chemotaxis to neuropeptides In: Nerozzi, DGoodwin, FKCosta, E eds. Hypothalamic Dysfunction in Neuropsychiatric Disorders New York: Raven Press, 1987;247-60Google ScholarPubMed
Shavit, YTerman, GWMartin, FCLewis, JWLiebeskind, JCGale, RPStress, opioid peptides, the immune system, and cancer J Immunol 1985;135: 834-7Google ScholarPubMed
Smith, EMBlalock, JEA complete regulatory loop between the immune and neuroendocrine systems operates through common signal molecules (hormones) and receptorsIn: Plotnikoff, NPFaith, REMurgo, AJGood, RA eds. Enkephalins and Endorphins: Stress and the Immune System New York: Plenum Press, 1986;118-9Google Scholar
Solomon, GSKay, NMorley, JEEndorphins: a link between personality, stress, emotions, immunity, and disease?In: Plotnikoff, NPFaith, REMurgo, AJGood, RA eds. Enkephalins and Endorphins: Stress and the Immune System New York: Plenum Press, 1986; 129-44CrossRefGoogle Scholar
Spitzer, RLEndicott, JRobin, EResearch Diagnostic Criteria: rationale and reliability Arch Gen Psychiatry 1978;35: 773-82CrossRefGoogle ScholarPubMed
Williams, JBSpitzer, RLResearch diagnostic criteria and DSM-III: an annotated comparison Arch Gen Psychiatry 1982;39: 1283-9CrossRefGoogle ScholarPubMed
Wybran, JEnkephalins and endorphins as modifiers of the immune system: present and future Fed Proc 1985;44: 92-4Google ScholarPubMed
Wybran, JAppelbloom, TFamely, JEGovaerts, ASuggestive evidence for receptors for morphine and methionine enkephalin on normal human blood T lymphocytes J Immunol 1979;123: 1068-70Google ScholarPubMed
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