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Defining and Understanding Treatment Resistance in Obsessive-Compulsive Disorder

Published online by Cambridge University Press:  19 July 2023

B. Dell’Osso
B. Dell’Osso*
Affiliation:
1Department of Mental Health, Department of Biomedical and Clinical Sciences Luigi Sacco 2“Aldo Ravelli” Center for Neurotechnology and Brain Therapeutic, University of Milan, Milan, Italy 3Department of Psychiatry and Behavioral Sciences, Bipolar Disorders Clinic, Stanford University, California, United States

Abstract

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Abstract

Previously considered a rare condition, OCD is now recognized as a common psychiatric disorder, with lifetime prevalence estimates ranging between 2% to 5%. Rates of resistance to first-line OCD treatments have been reported to be as high as 60%. Several clinical, biological and genetic factors have been investigated as treatment response moderators in OCD. These have included age at OCD onset, symptom subtypes, comorbidity patterns, gender and pharmacogenomics. This presentation will explore the definitions of treatment resistance in OCD as well as what is known about the epidemiology and clinical correlates associated with treatment resistance.

Disclosure of Interest

B. Dell’osso Grant / Research support from: LivaNova, Inc., Angelini, and Lundbeck

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S26
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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