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Decreased Resting-state fMRI Local Coherence in Schizophrenia Patients with Poor Long-term Outcome

Published online by Cambridge University Press:  01 September 2022

Y. Panikratova ,
E. Abdullina ,
D. Tikhonov ,
V. Kaleda  and
I. Lebedeva
Y. Panikratova
Affiliation:
Mental Health Research Center, Laboratory Of Neuroimaging And Multimodal Analysis, Moscow, Russian Federation
E. Abdullina*
Affiliation:
Mental Health Research Center, Laboratory Of Neuroimaging And Multimodal Analysis, Moscow, Russian Federation
D. Tikhonov
Affiliation:
Mental Health Research Center, Department Of Youth Psychiatry, Moscow, Russian Federation
V. Kaleda
Affiliation:
Mental Health Research Center, Department Of Youth Psychiatry, Moscow, Russian Federation
I. Lebedeva
Affiliation:
Mental Health Research Center, Laboratory Of Neuroimaging And Multimodal Analysis, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Schizophrenia is heterogeneous in terms of symptoms and outcome, but neurobiology of this heterogeneity is not well-studied. Local correlation analysis of fMRI data provides a measure of local coherence, i.e., average correlation between BOLD-signal in a voxel and its neighbours. Local correlation is a promising approach, and it seems important to find links between local brain coherence and schizophrenia outcome.

Objectives

We aimed to compare brain local coherence between schizophrenia patients with varied long-term outcomes and healthy controls (HC).

Methods

Patients with chronic schizophrenia spectrum disorders (37 males, mean age 41.5±5.5) and HC (17 males, mean age 38±7.7) underwent resting-state fMRI (3T). Cluster analysis based on PANSS and PSP allowed us to allocate patients into two subgroups (N = 13/24). The second subgroup had significantly more marked negative and general psychopathology symptoms and worse functioning than the first subgroup. Local coherence in the brain was compared between clinical subgroups and HC (ANOVA, p<.001 voxelwise, p[FDR]<.05 clusterwise).

Results

Local coherence in the paracingulate gyri bilaterally ({-2; 58; 14}; 2712 mm3) differentiated the groups. Post hoc analysis revealed decreased local coherence in the subgroup with poorer outcome compared to HC, along with the absence of differences between the subgroup with better outcome and HC. There were no differences between clinical subgroups.

Conclusions

Hypoactivity of the cingulate cortex is related to negative symptoms (Bersani et al., 2014). Their severity, in turn, is strongly associated with outcome. Thus, local coherence in the cingulate cortex may be one of the factors which underlie outcome heterogeneity.

Disclosure

No significant relationships.

Keywords

resting-state fMRILocal Correlationoutcomeschizophrénia
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S247
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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