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Decreased interhemispheric functional coordination underlying the cognitive impairment in late-onset depression

Published online by Cambridge University Press:  23 March 2020

Z. Hou ,
W. Jiang ,
Y. Yue ,
Y. Yin ,
Y. Zhang ,
Y. Sui  and
Y. Yuan
Z. Hou*
Affiliation:
Affiliated Zhongda Hospital of Southeast University, Medical School of Southeast University, Psychiatry, Nanjing, China
W. Jiang
Affiliation:
Affiliated Zhongda Hospital of Southeast University, Medical School of Southeast University, Psychiatry, Nanjing, China
Y. Yue
Affiliation:
Affiliated Zhongda Hospital of Southeast University, Medical School of Southeast University, Psychiatry, Nanjing, China
Y. Yin
Affiliation:
Affiliated Zhongda Hospital of Southeast University, Medical School of Southeast University, Psychiatry, Nanjing, China
Y. Zhang
Affiliation:
Affiliated Zhongda Hospital of Southeast University, Medical School of Southeast University, Psychiatry, Nanjing, China
Y. Sui
Affiliation:
Affiliated Nanjing Brain Hospital of Nanjing Medical University, Psychiatry, Nanjing, China
Y. Yuan
Affiliation:
Affiliated Zhongda Hospital of Southeast University, Medical School of Southeast University, Psychiatry, Nanjing, China
*
*Corresponding author.

Abstract

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Background

The intuitive association between cognitive dysfunction in late onset depression (LOD) and the aberrant functional activity in the brain's default-mode network (DMN) has prompted interest in exploring the role of the DMN in LOD. The altered pattern of resting state voxel-mirrored homotopic connectivity (VMHC) in cognitive processes is not yet well understood in LOD.

Methods

The study was designed to examine the implicit coupling between the alteration of interhemispheric functional coordination and cognitive impairment in LOD. Thirty-one LOD patients and 37 matched healthy controls (HC) underwent neuropsychological tests and functional magnetic resonance imaging (fMRI) in this study.

Results

Compared to HC group, attenuated VMHC in superior frontal gyrus, superior temporal gyrus, posterior cerebellar lobe, postcentral and precentral gyrus was observed in LOD. Neuro-behavioral relevancy approach revealed that the imbalanced interhemispheric functional coordination in bilateral cerebellum was positively correlated with the performance of trail making test in LOD (r = 0.367, P = 0.040).

Conclusion

Altered linkage pattern of intrinsic homotopic connectivity and cognition was firstly investigated in LOD, and it would provide a novel clue to reveal the neural substrates underlying the cognitive dysfunction in LOD.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Keywords

Late-onset depressionVoxel-mirrored homotopic connectivityFunctional magnetic resonance imagingCognitive functionCerebellum
Type
EW344
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S197
Copyright
Copyright © European Psychiatric Association 2016
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