Sexual behavior is determined by a compelx interplay of pschosocial and biological factors. Evaluation of sexual disorders inlcudes an evaluation of psychosocial factors such as cultural influences, life history, individual psychodynamics, couple interaction patterns, life stage as well as biological factors such as current medications, medical illness, psychiatric illness and endocrinological status. Sexual fucntioning usually declines in woman during the menopausal transition and this decline is related to decling estradiol levels. In spite of this, the major factor predicting postmenaopausal sexual function is premenopausal sexual function and relationship with the sexual partner. THere has been minimal study of psychologicalfactors influencing male sexual desire. Intervention requies an integrated approach with equal consideration to numerous possible etiological factors.