Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-25T14:38:14.255Z Has data issue: false hasContentIssue false

Cortisol Awakening Response in Symptomatic Patients with anorexia Nervosa and Bulimia Nervosa Exposed to Childhood Trauma

Published online by Cambridge University Press:  15 April 2020

F. Pellegrino
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy
A.M. Monteleone
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy
P. Scognamiglio
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy
L. Steardo
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy
U. Volpe
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy
P. Monteleone
Affiliation:
Neuroscience Section Department of Medicine and Surgery, University of Salerno, Salerno, Italy

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction

Childhood trauma exposure is a risk factor for adult psychopathology in general.

The biological mechanisms mediating this increased risk involve the endogenous stress response

system, including the hypothalamus-pituitary-adrenal (HPA) axis, that undergoes trauma-induced

functional changes, which may persist later in life. Since an association between stressful life events

and the onset/course of anorexia nervosa (AN) or bulimia nervosa (BN) has been demonstrated, a

role for the HPA axis in their pathophysiology seems likely.

Objectives and Aims

The cortisol awakening response (CAR) is a useful method to assess

the functioning of HPA axis. Therefore, we conducted an explorative study aiming to examine

possible associations between childhood maltreatments and HPA axis functioning, as assessed by the CAR, in adult patients with AN or BN.

Methods

Saliva samples were collected in 24 patients with acute AN, 22 with acute BN and

31 healthy controls at wakening and after 15, 30 and 60 min. They filled in the Childhood Trauma

Questionnaire (CTQ), which assesses five specific forms of childhood maltreatment.

Results

As compared to control group, no-maltreated AN group exhibited an enhanced CAR

whereas no-maltreated BN group showed a normal CAR. Moreover, both AN and BN patients with

childhood maltreatment exhibited a statistically significant blunted CAR as compared to no-maltreated patients.

Discussion

Present findings suggest that childhood adverse experiences may affect the CAR

in adults with AN or BN and this may represent a functional background of the endogenous stress

response system, which may have relevant implications in the pathophysiology of EDs.

Type
Article: 1352
Copyright
Copyright © European Psychiatric Association 2015
Submit a response

Comments

No Comments have been published for this article.