Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-22T06:17:25.876Z Has data issue: false hasContentIssue false
  • English
  • Français

Correlations between standard auditory evoked potentials and symptomatology in a group of 50 schizophrenic patients

Published online by Cambridge University Press:  16 April 2020

T Bougerol ,
A Benraiss  and
JC Scotto
T Bougerol
Affiliation:
Department of Adult Psychiatry, Sainte-Marguerite Hospital, Marseille, F13294France
A Benraiss
Affiliation:
Department of Adult Psychiatry, Sainte-Marguerite Hospital, Marseille, F13294France
JC Scotto
Affiliation:
Department of Adult Psychiatry, Sainte-Marguerite Hospital, Marseille, F13294France
Get access

Summary

Standard auditory evoked potentials (AEP) were recorded in 50 schizophrenic patients and 47 normal controls. All patients were rated on the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Negative Symptoms (SANS), the Scale for the Assessment of Positive Symptoms (SAPS), and the Positive and Negative Syndrome Scale (PANSS), and were classified in three groups (positive-type [n = 10], negative-type [n = 23]and mixed-type [n = 17]patients) according to the normative criteria suggested by Kay. The mean latencies of AEP components (N1, P2, N2) and mean peak-to-peak amplitudes (N1P2, P2N2) did not correlate with age, duration of illness, length of hospitalisation or neuroleptic dosage. The evoked response did not differ between the three groups of patients (positive, negative and mixed). There was only a trend (P = 0.075) to a longer N1 latency in the negative-type group and a shorter one in the positive-type group than in the mixed-type and the control groups. The latency of N1 component correlated significantly with negative symptoms of schizophrenia (SANS scores). This correlation was related to the severity of a depressive dimension of the disorder reflected by the “depressive factor” of BPRS or “affective flattening” and “avolition” subscales of SANS.

Keywords

evoked potentialschizophreniadepression
Type
Original article
Information
European Psychiatry , Volume 12 , Issue 8 , 1997 , pp. 387 - 394
Copyright
Copyright © Elsevier, Paris 1997

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adler, GGattaz, WFAuditoryevoked potentials in schizophrenic patients before during neuroleptic treatment. Relationship to psychopathological state Eur Arch Psychiatry Clin Neurosci 242 1993 357–361CrossRefGoogle Scholar
Adler, LEPachtman, EFranks, RDPechevitch, MWaldo, MCFreedman, RNeurophysiological evidence for a defect in neural mechanisms involved in sensory gating in schizophrenia Biol Psychiatry 17 1982 639–654Google Scholar
Andreasen, NCOlsen, SNegative/positive schizophrenia: definition and validation Arch Gen Psychiatry 39 1982 789–794CrossRefGoogle Scholar
Baribeau-Braun, JPicton, TWGoselin, JYSchizophrenia: a neurophysiological evaluation of abnormal information processing Science 219 1983 874CrossRefGoogle ScholarPubMed
Blackwood, DHRWhalley, LJChristie, JEBlackburn, IMStClair, DMMcInnes, AChanges in auditory P3 eventrelated potential in schizophrenia and depression Brit J Psychiatry 150 1987 154–160CrossRefGoogle Scholar
Braff, DLSaccuzzo, DPThe time course of information-processing deficits in schizophrenia Am J Psychiatry 142 1985 170–174Google Scholar
Bruder, GTowey, JStewart, DFriedman, HTenke, CQuitkin, FMEvent-related potentials in depression: influence of tasks, stimulus hemifield and clinical features on P3 latency Biol Psychiatry 30 1991 233–246CrossRefGoogle ScholarPubMed
Catts, SVShelley, AMWard, PBLiebert, BMcConaghy, NAndrews, SMichie, PTBrain potential evidence for an auditory sensory memory deficit in schizophrenia Am J Psychiatry 152 1995 213–219Google Scholar
Comblatt, BALenzenweger, MFDworkin, RHPositive and negative schizophrenic symptoms, attention and information processing Schizophr Bull 11 1985 397–407CrossRefGoogle Scholar
Davis, JMComparative doses and costs of antipsychotic medications Arch Gen Psychiatry 33 1976 858–861CrossRefGoogle Scholar
Drouet, AHort-Legrand, CFéline, AMetral, SSymptomatologie schizophrénique négative et onde P300 Encéphale XIX 1993 229–235Google Scholar
Faux, SFMcCarley, RWNestor, PGShenton, MEPollak, SDPenhune, V, et al.P300 topographic asymmetries are present in unmedicated schizophrenics Electroencephalogr Clin Neurophysiol 88 1993 32–41CrossRefGoogle ScholarPubMed
Javitt, DCDoneshka, PGrochowski, SRitter, WImpaired mismatch negativity generation reflects widespread dysfunction of working memory in schizophrenia Arch Gen Psychiatry 52 1995 550–558CrossRefGoogle Scholar
Judd, LLMcAdams, LBudnick, BBraff, DLSensory gating deficits in schizophrenia: new results Am J Psychiatry 149 1992 488–493Google ScholarPubMed
Kay, SRPositive and negative syndromes in schizophrenia. Assessment and research 1991 Brunner/Mazel New YorkGoogle Scholar
Kay, SRFiszbein, AOpler, LAThe positive and negative syn drome scale (PANSS) for schizophrenia Schizophr Bull 13 1987 261–276CrossRefGoogle Scholar
Kerkhof, GAEvent-related potentials auditory signal detection. Their diurnal variation for morning-type and evening-type subjects Psychophysiol 19 1982 94–103CrossRefGoogle ScholarPubMed
Laurent, AGarcia-Larrea, LDalery, JTerra, JLD'Amato, TMarie-Cardine, MMauguière, FEtude du potentiel P300 dans la schizophrénie Encéphale XIX 1993 221–227Google Scholar
Louza, MRMaurer, KDifferences between paranoid and nonparanoid schizophrenic patients on the somatosensory P300 event-related potential Neuropsychobiol 21 1989 59–66CrossRefGoogle ScholarPubMed
Nuechterlein, KHDawson, MENeurophysiological and psychophysiological approaches to schizophrenia In: Bloom, FEKupfer, DJ eds. Psychopharmacology: the fourth generation of progress 1995 Raven Press New York1235–1244Google Scholar
Overall, JEThe Brief Psychiatric Rating Scale in psychopharmacological research In: Pichot, P ed. Psychological measurements in psyche-pharmacology: modern problems in psychopharmacology vol 7 1976 Basel 67–68Google Scholar
Overall, JEGorham, DRThe Brief Psychiatric Rating Scale Psychol Rep 10 1962 799–812CrossRefGoogle Scholar
Partiot, APierson, ALe, Houezec JDodin, VRenault, BJouvent, RLoss of automatic processes and blunted-affect in depression: a P3 study Eur Psychiatry 8 1993 309–318CrossRefGoogle Scholar
Pfefferbaum, AWenegrat, BGFord, JMRoth, WTKoppel, BSClinical application of the P3 component of event-related potentials. II: dementia, depression and schizophrenia Electroencephalogr Clin Neurophysiol 59 1984 104–124CrossRefGoogle Scholar
Picton, TWHillyard, SAEndogenous event-related potentials In: Picton, TW ed. Handbook of Electroencephalography and Clinical Neurophysialogy vol 3 1988 Elsevier Amsterdam361–426Google Scholar
Pierson, APartiot, AAmmar, S, et al.ERPs: differences between anxious-impulsive and blunted-affect depressive in-patients In: Ansseau, MVon, Frenckell RFranck, G eds. Biological markers of depression: state of the art 1991 Elsevier Amsterdam121–129Google Scholar
Roth, WTCannon, EHSome features of the auditory evoked response in schizophrenics Arch Gen Psychiatry 27 1972 466–471CrossRefGoogle ScholarPubMed
Saletu, BItil, TMSaletu, MAuditory evoked response, EEG, and thought process in schizophrenics Am J Psychiatry 128 1971 336–344CrossRefGoogle ScholarPubMed
Saletu, BSaletu, MSimeon, JMarasa, JFluphenazine treatment in the psychotic child: clinical-evoked potential correlations Compr Psychiatry 16 1975 265–278CrossRefGoogle ScholarPubMed
Schliegel, SNieber, DHerrman, CBakauski, ELatencies of the P300 component of the auditory event related potential in depression are related to the Beck Rafaelsen Melancholia scale but not to the Hamilton Rating Scale for Depression Acta Psychiatr Scand 83 1991 438–440CrossRefGoogle Scholar
Schwarzkopf, SBLamberti, JSJiminez, MKane, CFHendriks, MNasrallah, HAVisual evoked potential correlates of positive/negative symptoms in schizophrenia Biol Psychiatry 27 1990 400–410CrossRefGoogle Scholar
Shagass, CSensory evoked potentials in psychosis In: Begleiter, H ed. Evoked brain potentials and behavior 1979 Plenum Press New York467–498CrossRefGoogle Scholar
Shagass, CRoemer, RAStraumanis, JJAmadeo, MEvoked potential correlates of psychosis Biol Psychiatry 13 1978 163–184Google Scholar
Shagass, CStraumanis, JJRoemer, RAAmadeo, MEvoked potentials of schizophrenics in several sensory modalities Biol Psychiatry 12 1977 221–235Google ScholarPubMed
Shenton, MEFaux, SFMcCarley, RWBallinger, RColeman, MTorello, MDuffy, FHCorrelations between abnormal auditory P300 topography and positive symptoms in schizophrenia: a preliminary report Biol Psvchiatry 25 1989 710–716CrossRefGoogle ScholarPubMed
Strik, WKDierks, TMaurer, KAmplitudes of auditory P300 in remitted and residual schizophrenics —correlations with clinical features. Neuropsychobiol 27 1993 54–60CrossRefGoogle ScholarPubMed
Sutton, SBraren, MZubin, JJohn, EREvoked-potential correlates of stimulus uncertainty Science 150 1965 1187–1188CrossRefGoogle ScholarPubMed
Ward, PBCatts, SVFox, AMMichie, PTMcConaghy, NAuditory selective attention and event-related potentials in schizophrenia Brit J Psychiatry 158 1991 534–539CrossRefGoogle Scholar
Weiner, RUOpler, LAKay, SRMerriam, AEPapouchis, NVisual information processing in positive, mixed, and negative schizophrenic syndromes J Nerv Ment Dis 178 1990 616–626CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.