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The Correlation Between Mid-Brain Serotonin Transporter Availability and Intelligence Quotient in Healthy Volunteers

Published online by Cambridge University Press:  15 April 2020

P.Y. Tseng ,
I.H. Lee ,
K.C. Chen ,
P.S. Chen ,
N.T. Chiu ,
W.J. Yao ,
C.L. Chu ,
T.L. Yeh  and
Y.K. Yang
P.Y. Tseng
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
I.H. Lee
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
K.C. Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, National Cheng Kung University, Dou-Liou Branch, Yunlin, Taiwan
P.S. Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, National Cheng Kung University, Dou-Liou Branch, Yunlin, Taiwan
N.T. Chiu
Affiliation:
Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
W.J. Yao
Affiliation:
Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
C.L. Chu
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
T.L. Yeh
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
Y.K. Yang*
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
*
*Corresponding author. Department of Psychiatry, National Cheng Kung University Hospital, 138, Shen Li Road, 704 Tainan, Taiwan. Tel.: +886 6 2353535x5213; fax: +886 6 2084767. E-mail address:[email protected] (Y.K. Yang).
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Abstract

Purpose:

This study was performed to investigate the association between the mid-brain serotonin transporter (SERT) availability and intelligence quotient (IQ).

Methods:

One hundred and thirteen healthy participants, including 52 male and 61 female subjects, were recruited. We used SPECT with [123I]ADAM images to determine the SERT availability in the mid-brain, and measured the subjects’ IQ using the WAIS-R.

Results:

We found a significant positive correlation between the mid-brain SERT availability and the IQ of the participants. Even when controlling for age and sex, the significant association still existed.

Conclusion:

This result implied that the higher the SERT binding in the mid-brain, the better the IQ in healthy participants.

Keywords

Serotonin transporter availabilityIntelligence quotientCognitive function[123I]ADAMSPECT
Type
Original article
Information
European Psychiatry , Volume 30 , Issue 2 , February 2015 , pp. 193 - 197
Copyright
Copyright © Elsevier Masson SAS 2014

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References

Baker, K.G., Halliday, G.M., Hornung, J.P., Geffen, L.B., Cotton, R.G., Tork, I.. Distribution, morphology and number of monoamine-synthesizing and substance P-containing neurons in the human dorsal raphe nucleus. Neuroscience 1991;42 :757–775.CrossRefGoogle ScholarPubMed
Benmansour, S., Piotrowski, J.P., Altamirano, A.V., Frazer, A.. Impact of ovarian hormones on the modulation of the serotonin transporter by fluvoxamine. Neuropsychopharmacology 2009;34 :555–564.CrossRefGoogle ScholarPubMed
Bennett, A.J., Lesch, K.P., Heils, A., Long, J.C., Lorenz, J.G., Shoaf, S.E., et al.Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry 2002;7 :118–122.CrossRefGoogle ScholarPubMed
Bethea, C.L., Lu, N.Z., Gundlah, C., Streicher, J.M.. Diverse actions of ovarian steroids in the serotonin neural system. Front Neuroendocrinol 2002;23 :41–100.CrossRefGoogle ScholarPubMed
Bethea, C.L., Pecins-Thompson, M., Schutzer, W.E., Gundlah, C., Lu, Z.N.. Ovarian steroids and serotonin neural function. Mol Neurobiol 1998;18 :87–123.CrossRefGoogle ScholarPubMed
Broca, P.. New finding of aphasia following a lesion of the posterior part of the second and third frontal convolutions. Bull Soc Anatomique 1861;6 :398–407.Google Scholar
Burke, S.M., van de Giessen, E., de Win, M., Schilt, T., van Herk, M., van den Brink, W., et al.Serotonin and dopamine transporters in relation to neuropsychological functioning, personality traits and mood in young adult healthy subjects. Psychol Med 2011;41 :419–429.CrossRefGoogle ScholarPubMed
Catafau, A.M., Perez, V., Penengo, M.M., Bullich, S., Danus, M., Puigdemont, D., et al.SPECT of serotonin transporters using 123I-ADAM: optimal imaging time after bolus injection and long-term test-retest in healthy volunteers. J Nucl Med 2005;46 :1301–1309.Google ScholarPubMed
Charlton, R.A., Barrick, T.R., McIntyre, D.J., Shen, Y., O'sullivan, M., Howe, F.A., et al.White matter damage on diffusion tensor imaging correlates with age-related cognitive decline. Neurology 2006;66 :217–222.CrossRefGoogle ScholarPubMed
Chen, P.S., Yang, Y.K., Lee, Y.S., Yeh, T.L., Lee, I.H., Chiu, N.T., et al.Correlation between different memory systems and striatal dopamine D2/D3 receptor density: a single photon emission computed tomography study. Psychol Med 2005;35 :197–204.CrossRefGoogle ScholarPubMed
Deary, I.J., Penke, L., Johnson, W.. The neuroscience of human intelligence differences. Nat Rev Neurosci 2010;11 :201–211.CrossRefGoogle ScholarPubMed
Erlandsson, K., Sivananthan, T., Lui, D., Spezzi, A., Townsend, C.E., Mu, S., et al.Measuring SSRI occupancy of SERT using the novel tracer [123I]ADAM: a SPECT validation study. Eur J Nucl Med Mol Imaging 2005;32 :1329–1336.CrossRefGoogle ScholarPubMed
Guo, J.F., Yang, Y.K., Chiu, N.T., Yeh, T.L., Chen, P.S., Lee, I.H., et al.The correlation between striatal dopamine D2/D3 receptor availability and verbal intelligence quotient in healthy volunteers. Psychol Med 2006;36 :547–554.CrossRefGoogle ScholarPubMed
Hornung, J.P.. The human raphe nuclei and the serotonergic system. J Chem Neuroanat 2003;26 :331–343.CrossRefGoogle ScholarPubMed
Hsieh, P.C., Chen, K.C., Yeh, T.L., Lee, I.H., Chen, P.S., Yao, W.J., et al.Lower availability of mid-brain serotonin transporter between healthy subjects with and without a family history of major depressive disorder – a preliminary two-ligand SPECT study. Eur Psychiatry 2014. http://dx.doi.org/10.1016/j.eurpsy.2013.11.004.CrossRefGoogle ScholarPubMed
Hsieh, P.C., Yeh, T.L., Lee, I.H., Huang, H.C., Chen, P.S., Yang, Y.K., et al.Correlation between errors on the Wisconsin Card Sorting Test and the availability of striatal dopamine transporters in healthy volunteers. J Psychiatry Neurosci 2010;35 :90–94.CrossRefGoogle ScholarPubMed
Huang, C.I., Yao, W.J., Sun, Y.N.. New methods for registering long-time I-123 ADAM SPECT image sequences to magnetic resonance images. Nucl Med Commun 2010;31 :734–740.CrossRefGoogle ScholarPubMed
Huang, Y., Zheng, M.Q., Gerdes, J.M.. Development of effective PET and SPECT imaging agents for the serotonin transporter: has a twenty-year journey reached its destination?. Curr Top Med Chem 2010;10 :1499–1526.CrossRefGoogle Scholar
Hughes, J.H., Gallagher, P., Stewart, M.E., Matthews, D., Kelly, T.P., Young, A.H.. The effects of acute tryptophan depletion on neuropsychological function. J Psychopharmacol 2003;17 :300–309.CrossRefGoogle ScholarPubMed
Jung, R.E., Haier, R.J.. The Parieto-Frontal Integration Theory (P-FIT) of intelligence: converging neuroimaging evidence. Behav Brain Sci 2007;30 :135–154. [discussion 54–87].CrossRefGoogle ScholarPubMed
Kish, S.J., Lerch, J., Furukawa, Y., Tong, J., McCluskey, T., Wilkins, D., et al.Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study. Brain 2010;133 :1779–1797.CrossRefGoogle Scholar
Krakowski, M.. Violence and serotonin: influence of impulse control, affect regulation, and social functioning. J Neuropsychiatry Clin Neurosci 2003;15 :294–305.CrossRefGoogle ScholarPubMed
Kung, H.F., Newman, S., Choi, S.R., Oya, S., Hou, C., Zhuang, Z.P., et al.2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent. J Med Chem 2004;47 :5258–5264.CrossRefGoogle ScholarPubMed
Kung, M.P., Hou, C., Oya, S., Mu, M., Acton, P.D., Kung, H.F.. Characterization of [(123)I]IDAM as a novel single-photon emission tomography tracer for serotonin transporters. Eur J Nucl Med 1999;26 :844–853.CrossRefGoogle ScholarPubMed
Laruelle, M.. Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review. J Cereb Blood Flow Metab 2000;20 :423–451.CrossRefGoogle ScholarPubMed
LeMarquand, D., Pihl, R.O., Benkelfat, C.. Serotonin and alcohol intake, abuse, and dependence: clinical evidence. Biol Psychiatry 1994;36 :326–337.CrossRefGoogle ScholarPubMed
Madsen, K., Erritzoe, D., Mortensen, E.L., Gade, A., Madsen, J., Baare, W., et al.Cognitive function is related to fronto-striatal serotonin transporter levels: a brain PET study in young healthy subjects. Psychopharmacology (Berl) 2011;213 :573–581.CrossRefGoogle ScholarPubMed
Malison, R.T., Price, L.H., Berman, R., van Dyck, C.H., Pelton, G.H., Carpenter, L., et al.Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography. Biol Psychiatry 1998;44 :1090–1098.CrossRefGoogle Scholar
McCann, U.D., Szabo, Z., Vranesic, M., Palermo, M., Mathews, W.B., Ravert, H.T., et al.Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/−)3,4-methylenedioxymethamphetamine (“ecstasy”) users: relationship to cognitive performance. Psychopharmacology (Berl) 2008;200 :439–450.CrossRefGoogle ScholarPubMed
McQueen, J.K., Wilson, H., Fink, G.. Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT binding sites in female rat brain. Brain Res Mol Brain Res 1997;45 :13–23.CrossRefGoogle ScholarPubMed
Mountz, J.D., Hsu, H.-C., Wu, Q., Liu, H.-G., Zhang, H.-G., Mountz, J.M.. Molecular imaging: new applications for biochemistry. J Cell Biochem 2002;87 :162–171.CrossRefGoogle Scholar
Mozley, L.H., Gur, R.C., Mozley, P.D., Gur, R.E.. Striatal dopamine transporters and cognitive functioning in healthy men and women. Am J Psychiatry 2001;158 :1492–1499.CrossRefGoogle ScholarPubMed
Nathan, P.J., Sitaram, G., Stough, C., Silberstein, R.B., Sali, A.. Serotonin, noradrenaline and cognitive function: a preliminary investigation of the acute pharmacodynamic effects of a serotonin versus a serotonin and noradrenaline reuptake inhibitor. Behav Pharmacol 2000;11 :639–642.CrossRefGoogle ScholarPubMed
O'sullivan, M., Jones, D.K., Summers, P.E., Morris, R.G., Williams, S.C., Markus, H.S.. Evidence for cortical “disconnection” as a mechanism of age-related cognitive decline. Neurology 2001;57 :632–638.CrossRefGoogle ScholarPubMed
Oya, S., Choi, S.R., Hou, C., Mu, M., Kung, M.P., Acton, P.D., et al.2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nucl Med Biol 2000;27 :249–254.CrossRefGoogle ScholarPubMed
Park, D.C.The basic mechanisms accounting for age-related decline in cognitive function. In: Park, D.C., Schwarz, N. editors. Cognitive aging: a primer. New York, NY, US: Psychology Press; 2000. 3–21.Google Scholar
Reneman, L., Lavalaye, J., Schmand, B., de Wolff, F.A., van den Brink, W., den Heeten, G.J., et al.Cortical serotonin transporter density and verbal memory in individuals who stopped using 3,4-methylenedioxymethamphetamine (MDMA or “ecstasy”): preliminary findings. Arch Gen Psychiatry 2001;58 :901–906.CrossRefGoogle ScholarPubMed
Riedel, W.J., Klaassen, T., Deutz, N.E., van Someren, A., van Praag, H.M.. Tryptophan depletion in normal volunteers produces selective impairment in memory consolidation. Psychopharmacology (Berl) 1999;141 :362–369.CrossRefGoogle ScholarPubMed
Robbins, T.W., Arnsten, A.F.. The neuropsychopharmacology of fronto-executive function: monoaminergic modulation. Annu Rev Neurosci 2009;32 :267–287.CrossRefGoogle ScholarPubMed
Salthouse, T.A., Atkinson, T.M., Berish, D.E.. Executive functioning as a potential mediator of age-related cognitive decline in normal adults. J Exp Psychol Gen 2003;132 :566–594.CrossRefGoogle ScholarPubMed
Sarter, M., Bruno, J.P.. Developmental origins of the age-related decline in cortical cholinergic function and associated cognitive abilities. Neurobiol Aging 2004;25 :1127–1139.CrossRefGoogle ScholarPubMed
Sattler, J.M., Ryan, J.J.Assessment with the WAIS-IV. .San Diego, CA: Sattler JM; 2009.Google Scholar
Schmitt, J.A., Jorissen, B.L., Sobczak, S., van Boxtel, M.P., Hogervorst, E., Deutz, N.E., et al.Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteers. J Psychopharmacol 2000;14 :21–29.CrossRefGoogle ScholarPubMed
Schmitt, J.A., Wingen, M., Ramaekers, J.G., Evers, E.A., Riedel, W.J.. Serotonin and human cognitive performance. Curr Pharm Des 2006;12 :2473–2486.CrossRefGoogle ScholarPubMed
Sheehan, D.V., Lecrubier, Y., Sheehan, K.H., Amorim, P., Janavs, J., Weiller, E., et al.The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998;59 (Suppl. 20):22–33.Google ScholarPubMed
Sherwin, B.B.. Estrogen and cognitive functioning in women. Endocr Rev 2003;24 :133–151.CrossRefGoogle ScholarPubMed
Siever, L.J.. Neurobiology of aggression and violence. Am J Psychiatry 2008;165 :429–442.CrossRefGoogle ScholarPubMed
Skevington, S.M., Wright, A.. Changes in the quality of life of patients receiving antidepressant medication in primary care: validation of the WHOQOL-100. Br J Psychiatry 2001;178 :261–267.CrossRefGoogle ScholarPubMed
Stahl, S.M.Essential psychopharmacology: neuroscientific basis and practical application. 2nd ed.. New York: Cambridge University Press; 2000.Google Scholar
Stengler-Wenzke, K., Muller, U., Angermeyer, M.C., Sabri, O., Hesse, S.. Reduced serotonin transporter availability in obsessive compulsive disorder (OCD). Eur Arch Psychiatry Clin Neurosci 2004;254 :252–255.CrossRefGoogle Scholar
Tsai, H.Y., Lee, I.H., Yeh, T.L., Yao, W.J., Chen, K.C., Chen, P.S., et al.Association between the dexamethasone suppression test and serotonin transporter availability in healthy volunteer: a SPECT with [(123)I] ADAM study. Eur Neuropsychopharmacol 2012;22 :641–646.CrossRefGoogle Scholar
van Dyck, C.H., Malison, R.T., Seibyl, J.P., Laruelle, M., Klumpp, H., Zoghbi, S.S., et al.Age-related decline in central serotonin transporter availability with [(123)I]beta-CIT SPECT. Neurobiol Aging 2000;21 :497–501.CrossRefGoogle Scholar
Wechsler, D.Wechsler Adult Intelligence Scale-Revised Manual. Anglicized edition ed.London: Psychological Corporation; 1986.Google Scholar
Wernicke, C.Der aphasische symptomenkomplex: eine psychologische studie auf anatomischer basis. Breslau: Cohn and Weigert; 1874.Google Scholar
Wharton, W., Baker, L.D., Gleason, C.E., Dowling, M., Barnet, J.H., Johnson, S., et al.Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trial. J Alzheimers Dis 2011;26 :495–505.CrossRefGoogle ScholarPubMed
Wihlback, A.C., Sundstrom Poromaa, I., Bixo, M., Allard, P., Mjorndal, T., Spigset, O.Influence of menstrual cycle on platelet serotonin uptake site and serotonin2A receptor binding. Psychoneuroendocrinology 2004;29 :757–766.CrossRefGoogle ScholarPubMed
Yamamoto, M., Suhara, T., Okubo, Y., Ichimiya, T., Sudo, Y., Inoue, M., et al.Age-related decline of serotonin transporters in living human brain of healthy males. Life Sci 2002;71 :751–757.CrossRefGoogle ScholarPubMed
Yang, Y.K., Yao, W.J., Yeh, T.L., Lee, I.H., Chen, K.C., Lu, R.B.Association between serotonin transporter availability and hostility scores in healthy volunteers - a single photon emission computed tomography study with [(123)I] ADAM. Psychiatry Res 2007;154 :281–284.CrossRefGoogle ScholarPubMed
Yeh, T.L., Chen, K.C., Lin, S.H., Lee, I.H., Chen, P.S., Yao, W.J., et al.Availability of dopamine and serotonin transporters in opioid-dependent users: a two-isotope SPECT study. Psychopharmacology (Berl) 2012;220 :55–64.CrossRefGoogle ScholarPubMed
Yeh, T.L., Lee, I.H., Chen, K.C., Chen, P.S., Yao, W.J., Yang, Y.K., et al.The relationships between daily life events and the availabilities of serotonin transporters and dopamine transporters in healthy volunteers: a dual-isotope SPECT study. Neuroimage 2009;45 :275–279.CrossRefGoogle ScholarPubMed
Zitterl, W., Aigner, M., Stompe, T., Zitterl-Eglseer, K., Gutierrez-Lobos, K., Wenzel, T., et al.Changes in thalamus-hypothalamus serotonin transporter availability during clomipramine administration in patients with obsessive-compulsive disorder. Neuropsychopharmacology 2008;33 :3126–3134.CrossRefGoogle ScholarPubMed
Zitterl, W., Stompe, T., Aigner, M., Zitterl-Eglseer, K., Ritter, K., Zettinig, G., et al.Diencephalic serotonin transporter availability predicts both transporter occupancy and treatment response to sertraline in obsessive-compulsive checkers. Biol Psychiatry 2009;66 :1115–1122.CrossRefGoogle ScholarPubMed
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