During the last 10 years a large volume of circumstantial evidence for an autoimmune aethiology of at least some cases of schizophrenia (SCH) has been collected.

We present the female patient (S.M.), now 41 years old, with four autoimmune diseases and psychosis schizoaffectiva.

Until the age of 2 S.M. had lactae crustae in extremely severe form. From the age of 3-6 she suffered of asthma bronchiale. At the age of 34 she developed the clinical picture of Myasthenia gravis (MG). One year later she got a new relapse of MG. During the diagnostic procedures for MG, just by mistake, an MRI of the brain has been made instead of the MRI of anterior mediastinum, which revealed a huge amount of the demyelinated plaques without any clinical symptoms of Multiple sclerosis (MS). Immunologic examination of the cerebrospinal fluid and evoked potentials examination confirmed the diagnosis of MS. At the age of 40 she got her only up till now clinical relapse of MS.

At the age of 22 S.M. got the first relapse of psychosis compatible with the diagnosis of Psychosis schizoaffectiva. Her psychosis has relapsing course and over the years disabled her in emotional, professional and social capacity.

This case is one more among many cases presented in the literature to contribute to the hypothesis that at least some forms of SCH have the autoimmune origin, which could suggest that immunotherapy might be benefitial to such patients.