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The Concentration of the Factors Involved in Trafficking of Stem Cells in Long-Term Treated Bipolar Disorder Patients

Published online by Cambridge University Press:  23 March 2020

J. Kucharska-Mazur ,
A. Reginia ,
M. Jabłoński ,
B. Dołęgowska ,
J. Rybakowski ,
M.Z. Ratajczak  and
J. Samochowiec
J. Kucharska-Mazur
Affiliation:
Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland
A. Reginia
Affiliation:
Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland
M. Jabłoński
Affiliation:
Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland
B. Dołęgowska
Affiliation:
Department of Microbiology and Immunological Diagnostics, Pomeranian Medical University, Szczecin, Poland
J. Rybakowski
Affiliation:
Department of Adult Psychiatry, University of Medical Sciences, Poznań, Poland
M.Z. Ratajczak
Affiliation:
University of Louisville, Stem Cell Biology Program at the James Graham Brown Cancer CenterUSA
J. Samochowiec
Affiliation:
Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland

Abstract

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Introduction

After analysis of biological and pharmacological data, we formulated the hypothesis that the factors involved in trafficking of stem cells could be engaged in aetiology of bipolar disorder (BP).

Aims

In this study, we considered the role of complement cascade proteins, stromal derived factor-1 (SDF-1), and sphingosine-1-phosphate (S1P) in long-term treated BP.

Methods

A group of 30 patients with BP, without the history of lithium treatment, was examined in remission and compared with a group of 30 healthy volunteers. In peripheral blood, we have analysed the concentration of stromal derived factor-1 (SDF-1), sphingosine-1-phosphate (S1P), and some proteins of the complement cascade (C3a, C5a, C5b-9).

Results

Peripheral blood concentration of C3a, C5a, C5b-9 and SDF-1 was significantly higher in BP group compared to control group. The concentration of S1P does not distinguish BP patients from controls.

Conclusion

Our results suggest the possible role of the regeneration system in aetiology of BP.

This work was supported by grant POIG.01.01.02-00-109/09.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-poster walk: Bipolar disorders – Part 2
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S206
Copyright
Copyright © European Psychiatric Association 2017
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